PTGR1 prostaglandin reductase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGR1provided by HGNC
Official Full Name: prostaglandin reductase 1provided by HGNC
Primary source: HGNC:HGNC:18429
See related: Ensembl:ENSG00000106853 MIM:601274; AllianceGenome:HGNC:18429
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PGR1; DIG-1; ZADH3; LTB4DH
Summary: This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Expression: Broad expression in liver (RPKM 118.8), small intestine (RPKM 109.3) and 18 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q31.3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (111549722..111599647, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (123721096..123771025, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (114312002..114361927, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.
Title: The human PTGR1 gene expression is controlled by TE-derived Z-DNA forming sequence cooperating with miR-6867-5p.
PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.
Title: PTGR1 is involved in cell proliferation in thoracic ossification of the ligamentum flavum.
LTB4DH plays a pivotal role in alpha-galactosylceramide-pulsed dendritic cell immunotherapy for non-small cell lung cancer.
Title: Role of leukotriene B4 12-hydroxydehydrogenase in α-galactosylceramide-pulsed dendritic cell therapy for non-small cell lung cancer.
The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder.
Title: Novel involvement of miR-522-3p in high-mobility group box 1-induced prostaglandin reductase 1 expression and reduction of phagocytosis.
selenium had only a minor influence on prostaglandin reductase 1 (PTGR1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and protein levels
Title: Induction of complementary function reductase enzymes in colon cancer cells by dithiole-3-thione versus sodium selenite.
These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo.
Title: Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductase.
Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response.
Title: A set of genes associated with the interferon-γ response of lung cancer patients undergoing α-galactosylceramide-pulsed dendritic cell therapy.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
restoration of expression in enzyme-negative lung cancer cell lines induces apoptosis and growth inhibition
Title: Restoration of leukotriene B(4)-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variation associated with circulating monocyte count in the eMERGE Network. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

sY3084 (e-PCR)
- UniSTS:515126

A008V29 (e-PCR)
- UniSTS:34645

SHGC-33630 (e-PCR)
- UniSTS:27492

RH69266 (e-PCR)
- UniSTS:5582

RH66479 (e-PCR)
- UniSTS:12750

RH16615 (e-PCR)
- UniSTS:79597

SHGC-58823 (e-PCR)
- UniSTS:94459

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 13-lipoxin reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 13-prostaglandin reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables 15-oxoprostaglandin 13-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-alkenal reductase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables leukotriene B4 12-hydroxy dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in leukotriene B4 metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in leukotriene metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in lipoxin A4 metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular exosome	HDA more info	PubMed

General protein information

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Preferred Names: prostaglandin reductase 1

Names: 15-oxoprostaglandin 13-reductase; D3T-inducible gene 1 protein; NAD(P)H-dependent alkenal/one oxidoreductase; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; PRG-1; dithiolethione-inducible gene 1 protein; leukotriene B4 12-hydroxydehydrogenase; zinc binding alcohol dehydrogenase domain containing 3

NP_001139580.1

EC 1.3.1.48

EC 1.3.1.74

NP_001139581.1

EC 1.3.1.48

EC 1.3.1.74

NP_036344.2

EC 1.3.1.48

EC 1.3.1.74

XP_011516696.1

EC 1.3.1.48

EC 1.3.1.74

XP_011516697.1

EC 1.3.1.48

EC 1.3.1.74

XP_016869974.1

EC 1.3.1.48

EC 1.3.1.74

XP_047278965.1

EC 1.3.1.48

EC 1.3.1.74

XP_047278966.1

EC 1.3.1.48

EC 1.3.1.74

XP_054218368.1

EC 1.3.1.48

EC 1.3.1.74

XP_054218369.1

EC 1.3.1.48

EC 1.3.1.74

XP_054218370.1

EC 1.3.1.48

EC 1.3.1.74

XP_054218371.1

EC 1.3.1.48

EC 1.3.1.74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001146108.2 → NP_001139580.1 prostaglandin reductase 1 isoform 1

See identical proteins and their annotated locations for NP_001139580.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA876375, AK289597, AL135787

Consensus CDS

CCDS6779.1

UniProtKB/Swiss-Prot

A8K0N2, B4DPK3, F5GY50, Q14914, Q8IYQ0, Q9H1X6

Related

ENSP00000385763.2, ENST00000407693.7

Conserved Domains (2) summary

TIGR02825
Location:4 → 328

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase

cd08294
Location:2 → 329

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
NM_001146109.2 → NP_001139581.1 prostaglandin reductase 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter, compared to isoform 1.

Source sequence(s)

AK298379, AL135787

Consensus CDS

CCDS55331.1

Related

ENSP00000440281.1, ENST00000538962.7

Conserved Domains (1) summary

TIGR02825
Location:4 → 300

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
NM_012212.3 → NP_036344.2 prostaglandin reductase 1 isoform 1

See identical proteins and their annotated locations for NP_036344.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AA876375, AL135787, BC035228

Consensus CDS

CCDS6779.1

UniProtKB/Swiss-Prot

A8K0N2, B4DPK3, F5GY50, Q14914, Q8IYQ0, Q9H1X6

Related

ENSP00000311572.5, ENST00000309195.9

Conserved Domains (2) summary

TIGR02825
Location:4 → 328

B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase

cd08294
Location:2 → 329

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

111549722..111599647 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011518394.3 → XP_011516696.1 prostaglandin reductase 1 isoform X2

Conserved Domains (1) summary

cd08294
Location:2 → 253

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
XM_017014485.3 → XP_016869974.1 prostaglandin reductase 1 isoform X2

Conserved Domains (1) summary

cd08294
Location:2 → 253

leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity
XM_011518395.4 → XP_011516697.1 prostaglandin reductase 1 isoform X3

Conserved Domains (1) summary

cl16912
Location:1 → 206

MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
XM_047423009.1 → XP_047278965.1 prostaglandin reductase 1 isoform X1

UniProtKB/TrEMBL

F2Z3J9

Related

ENSP00000435665.2, ENST00000466771.6
XM_047423010.1 → XP_047278966.1 prostaglandin reductase 1 isoform X1

UniProtKB/TrEMBL

F2Z3J9