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    Lmo3 LIM domain only 3 [ Mus musculus (house mouse) ]

    Gene ID: 109593, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lmo3provided by MGI
    Official Full Name
    LIM domain only 3provided by MGI
    Primary source
    MGI:MGI:102810
    See related
    Ensembl:ENSMUSG00000030226 AllianceGenome:MGI:102810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lmo-3; Rbtn3; Rbtn-3
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade; positive regulation of glucocorticoid receptor signaling pathway; and positive regulation of peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; cochlea; spinal cord; and vestibulo-cochlear ganglion. Orthologous to human LMO3 (LIM domain only 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 16.5), frontal lobe adult (RPKM 10.9) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    6 G1; 6 69.02 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (138339916..138559204, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (138362918..138582206, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr6:138096406-138096707 Neighboring gene microsomal glutathione S-transferase 1 Neighboring gene predicted gene, 30213 Neighboring gene RIKEN cDNA A830011K09 gene Neighboring gene predicted gene, 30332 Neighboring gene RIKEN cDNA B230110G15 gene Neighboring gene immunoglobulin (CD79A) binding protein 1b Neighboring gene protein inhibitor of activated STAT 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Increased behavioral responses to ethanol in Lmo3 knockout mice. Savarese A, et al. Genes Brain Behav, 2014 Nov. PMID 25176312, Free PMC Article
    2. LMO3 reprograms visceral adipocyte metabolism during obesity. Wagner G, et al. J Mol Med (Berl), 2021 Aug. PMID 34018016, Free PMC Article
    3. Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3. Savarese A, et al. Psychoneuroendocrinology, 2018 Jun. PMID 29609111, Free PMC Article
    4. Bioluminescence-driven optogenetic activation of transplanted neural precursor cells improves motor deficits in a Parkinson's disease mouse model. Zenchak JR, et al. J Neurosci Res, 2020 Mar. PMID 29577367, Free PMC Article
    5. Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice. Isogai E, et al. Exp Anim, 2015. PMID 26156403, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
      Title: The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus.
    2. LMO3 reprograms visceral adipocyte metabolism during obesity.
      Title: LMO3 reprograms visceral adipocyte metabolism during obesity.
    3. These results suggest that Lmo3 promotes anxiety-like behavior specifically in the BLA, possibly by altering Crhr1 expression.
      Title: Regulation of anxiety-like behavior and Crhr1 expression in the basolateral amygdala by LMO3.
    4. suggested that the expression levels of Lmo3 and/or Hen2 could determine the fate of stem cells by inhibiting Hes1 function during nervous system development and might be a trigger of aberrant neurogenesis in vivo
      Title: Oncogenic Lmo3 cooperates with Hen2 to induce hydrocephalus in mice.
    5. These results support a role for LMO3 in regulating behavioral responses to ethanol, potentially through its actions in the nucleus accumbens.
      Title: Increased behavioral responses to ethanol in Lmo3 knockout mice.
    6. Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
      Title: Gbx2 regulates thalamocortical axon guidance by modifying the LIM and Robo codes.
    7. when tested for behavioral responses to ethanol, transgenic mice exhibited altered ethanol sedation and consumption that correlated with Lmo3 expression levels; results suggest a role for Lmo3 in ethanol-related behaviors in mice
      Title: Lmo genes regulate behavioral responses to ethanol in Drosophila melanogaster and the mouse.
    8. Data show that the calcium- and integrin-binding protein CIB as an LMO3-binding protein, which binds via the second LIM domain (LIM2) of LMO3.
      Title: The oncoprotein LMO3 interacts with calcium- and integrin-binding protein CIB.
    9. Results suggest that all four members of the LIM-only family -- LMO1, 2, 3, and 4 -- are important regulators of distinct developmental pathways.
      Title: Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within exploration behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT acts_upstream_of_or_within positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of peroxisome proliferator activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    LIM domain only protein 3
    Names
    LIM only 3
    neuronal-specific transcription factor DAT1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356305.2 → NP_001343234.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      Consensus CDS
      CCDS20669.1
      UniProtKB/Swiss-Prot
      Q8BZL8
      Conserved Domains (2) summary
      cd09388
      Location:13 → 67
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:77 → 131
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    2. NM_001356306.2 → NP_001343235.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      Consensus CDS
      CCDS20669.1
      UniProtKB/Swiss-Prot
      Q8BZL8
      Related
      ENSMUSP00000125589.2, ENSMUST00000163024.8
      Conserved Domains (2) summary
      cd09388
      Location:13 → 67
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:77 → 131
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    3. NM_001356307.2 → NP_001343236.1  LIM domain only protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      Consensus CDS
      CCDS90132.1
      UniProtKB/TrEMBL
      E9PWI9
      Related
      ENSMUSP00000124762.2, ENSMUST00000163065.8
      Conserved Domains (2) summary
      cd09388
      Location:24 → 78
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:88 → 142
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    4. NM_001411497.1 → NP_001398426.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    5. NM_001411498.1 → NP_001398427.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8
      Related
      ENSMUSP00000145048.2, ENSMUST00000203435.3

    6. NM_001411499.1 → NP_001398428.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    7. NM_001411500.1 → NP_001398429.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8
      Related
      ENSMUSP00000124862.2, ENSMUST00000161450.8

    8. NM_001411501.1 → NP_001398430.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    9. NM_001411502.1 → NP_001398431.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    10. NM_001411503.1 → NP_001398432.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    11. NM_001411504.1 → NP_001398433.1  LIM domain only protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215
      UniProtKB/Swiss-Prot
      Q8BZL8

    12. NM_207222.4 → NP_997105.1  LIM domain only protein 3 isoform 1

      See identical proteins and their annotated locations for NP_997105.1

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215, AC139755
      Consensus CDS
      CCDS20669.1
      UniProtKB/Swiss-Prot
      Q8BZL8
      Related
      ENSMUSP00000125335.2, ENSMUST00000162772.8
      Conserved Domains (2) summary
      cd09388
      Location:13 → 67
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:77 → 131
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    RNA

    1. NR_151448.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    2. NR_151449.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    3. NR_177275.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    4. NR_177276.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    5. NR_177277.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    6. NR_177278.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC121968, AC125215

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      138339916..138559204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255087.1 → XP_030110947.1  LIM domain only protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q8BZL8
      Conserved Domains (2) summary
      cd09388
      Location:13 → 67
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:77 → 131
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    2. XM_036165743.1 → XP_036021636.1  LIM domain only protein 3 isoform X1

      Conserved Domains (2) summary
      cd09388
      Location:40 → 94
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cd09389
      Location:104 → 158
      LIM2_LMO1_LMO3; The second LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)

    3. XM_006505343.5 → XP_006505406.1  LIM domain only protein 3 isoform X3

      Conserved Domains (2) summary
      cd09388
      Location:40 → 94
      LIM1_LMO1_LMO3; The first LIM domain of LMO1 and LMO3 (LIM domain only protein 1 and 3)
      cl02475
      Location:104 → 139
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RNA

    1. XR_377405.5 RNA Sequence

    2. XR_868844.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BZL8.1 GenPept UniProtKB/Swiss-Prot:Q8BZL8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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