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    Mfsd14a major facilitator superfamily domain containing 14A [ Mus musculus (house mouse) ]

    Gene ID: 15247, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mfsd14aprovided by MGI
    Official Full Name
    major facilitator superfamily domain containing 14Aprovided by MGI
    Primary source
    MGI:MGI:1201609
    See related
    Ensembl:ENSMUSG00000089911 AllianceGenome:MGI:1201609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hiat1
    Summary
    Predicted to enable transmembrane transporter activity. Acts upstream of or within acrosome assembly; sperm mitochondrion organization; and spermatid nucleus differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including brain; genitourinary system; heart; liver; and lung. Orthologous to human MFSD14A (major facilitator superfamily domain containing 14A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 21.5), placenta adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    3 G1; 3 50.42 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (116424813..116456264, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (116631164..116662688, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene splicing factor, arginine/serine-rich pseudogene Neighboring gene leucine rich repeat containing 39 Neighboring gene STARR-seq mESC enhancer starr_08780 Neighboring gene tRNA methyltransferase 13 Neighboring gene STARR-positive B cell enhancer ABC_E1630 Neighboring gene SAS-6 centriolar assembly protein Neighboring gene STARR-seq mESC enhancer starr_08781 Neighboring gene STARR-seq mESC enhancer starr_08784 Neighboring gene STARR-seq mESC enhancer starr_08785 Neighboring gene STARR-positive B cell enhancer ABC_E3464 Neighboring gene STARR-seq mESC enhancer starr_08789 Neighboring gene STARR-seq mESC enhancer starr_08790 Neighboring gene microRNA 3473h Neighboring gene solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member 3 Neighboring gene predicted gene, 40126

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice. Doran J, et al. Reproduction, 2016 Jul. PMID 27107036
    2. Cloning of a cDNA encoding a novel sugar transporter expressed in the neonatal mouse hippocampus. Matsuo N, et al. Biochem Biophys Res Commun, 1997 Sep 8. PMID 9299464
    3. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of Mfsd14a expression is associated with globozoospermia and male infertility.
      Title: Mfsd14a (Hiat1) gene disruption causes globozoospermia and infertility in male mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144858

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sperm mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatid nucleus differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hippocampus abundant transcript 1 protein
    Names
    hippocampus abundant gene transcript 1
    tetracycline transporter-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410014.1 → NP_001396943.1  hippocampus abundant transcript 1 protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC131038

    2. NM_001410015.1 → NP_001396944.1  hippocampus abundant transcript 1 protein isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC131038

    3. NM_001410016.1 → NP_001396945.1  hippocampus abundant transcript 1 protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC131038

    4. NM_001410017.1 → NP_001396946.1  hippocampus abundant transcript 1 protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC131038

    5. NM_001410018.1 → NP_001396947.1  hippocampus abundant transcript 1 protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC131038

    6. NM_001410019.1 → NP_001396948.1  hippocampus abundant transcript 1 protein isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC131038

    7. NM_001410020.1 → NP_001396949.1  hippocampus abundant transcript 1 protein isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC131038

    8. NM_001410021.1 → NP_001396950.1  hippocampus abundant transcript 1 protein isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC131038

    9. NM_001410022.1 → NP_001396951.1  hippocampus abundant transcript 1 protein isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC131038

    10. NM_001410023.1 → NP_001396952.1  hippocampus abundant transcript 1 protein isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC131038

    11. NM_001410024.1 → NP_001396953.1  hippocampus abundant transcript 1 protein isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC131038

    12. NM_001410025.1 → NP_001396954.1  hippocampus abundant transcript 1 protein isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC131038

    13. NM_001410026.1 → NP_001396955.1  hippocampus abundant transcript 1 protein isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC131038

    14. NM_001410027.1 → NP_001396956.1  hippocampus abundant transcript 1 protein isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC131038

    15. NM_008246.3 → NP_032272.2  hippocampus abundant transcript 1 protein isoform 1

      See identical proteins and their annotated locations for NP_032272.2

      Status: VALIDATED

      Source sequence(s)
      AC131038
      Consensus CDS
      CCDS17790.1
      UniProtKB/Swiss-Prot
      P70187, Q3TY74, Q9DBS0
      Related
      ENSMUSP00000029570.6, ENSMUST00000029570.9
      Conserved Domains (1) summary
      cd17387
      Location:37 → 449
      MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      116424813..116456264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240023.3 → XP_011238325.1  hippocampus abundant transcript 1 protein isoform X2

      See identical proteins and their annotated locations for XP_011238325.1

      Conserved Domains (1) summary
      cd17387
      Location:1 → 377
      MFS_MFSD14; Major facilitator superfamily domain-containing 14A and 14B
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70187.3 GenPept UniProtKB/Swiss-Prot:P70187

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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