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    Mmp13 matrix metallopeptidase 13 [ Mus musculus (house mouse) ]

    Gene ID: 17386, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Mmp13provided by MGI
    Official Full Name
    matrix metallopeptidase 13provided by MGI
    Primary source
    MGI:MGI:1340026
    See related
    Ensembl:ENSMUSG00000050578 AllianceGenome:MGI:1340026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clg; Mmp1; MMP-13
    Summary
    This gene encodes a member of the matrix metalloproteinase family that plays a role in wound healing, skeletal development and bone remodeling. The encoded protein is activated by the removal of an N-terminal activation peptide to generate a zinc-dependent endopeptidase enzyme that can cleave various native collagens, including types I - IV, X and XIV. Mice lacking the encoded protein display profound defects in growth plate cartilage as well as a delay in the endochondral bone development. Lack of the encoded protein also impairs the wound healing process due to reduced keratinocyte migration and vascular density at the wound site. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Jun 2015]
    Expression
    Biased expression in CNS E18 (RPKM 1.3), limb E14.5 (RPKM 0.9) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A1; 9 2.46 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7272514..7283333)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7272514..7283333)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 2 heavy chain 1 Neighboring gene STARR-positive B cell enhancer ABC_E6712 Neighboring gene defective in cullin neddylation 1 domain containing 5 Neighboring gene predicted gene, 31639 Neighboring gene STARR-seq mESC enhancer starr_23207 Neighboring gene STARR-seq mESC enhancer starr_23208 Neighboring gene STARR-seq mESC enhancer starr_23209 Neighboring gene STARR-seq mESC enhancer starr_23210 Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 1b (interstitial collagenase)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation. Liu M, et al. Cell Physiol Biochem, 2022 Dec 20. PMID 36537139
    2. MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma. Zhang W, et al. Comput Math Methods Med, 2022. PMID 36105241, Free PMC Article
    3. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Ponte F, et al. Sci Rep, 2022 Jun 17. PMID 35715555, Free PMC Article
    4. dsRNA Induced IFNβ-MMP13 Axis Drives Corneal Wound Healing. Lan X, et al. Invest Ophthalmol Vis Sci, 2022 Feb 1. PMID 35129588, Free PMC Article
    5. Selective Imaging of Matrix Metalloproteinase-13 to Detect Extracellular Matrix Remodeling in Atherosclerotic Lesions. Buchler A, et al. Mol Imaging Biol, 2022 Feb. PMID 34231104

    See all (406) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
      Title: [Effects of miR-143 on the migration and invasion of osteosarcoma cells by regulating MMP-13 expression].
    2. MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/beta-catenin signaling via HIF-1alpha upregulation in mouse embryonic fibroblasts.
      Title: MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts.
    3. Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
      Title: Matrix Metalloproteinase-1 Expression in Fibroblasts Accelerates Dermal Aging and Promotes Papilloma Development in Mouse Skin.
    4. The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
      Title: The Expression of MMP1 and MMP7 in Mice Liver after Exposure to Aflatoxin B1 Using Immunohistochemistry Technique.
    5. MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
      Title: MIA/CD-RAP Regulates MMP13 and Is a Potential New Disease-Modifying Target for Osteoarthritis Therapy.
    6. Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
      Title: Genetic screening of MMP1 as a potential pathogenic gene in chronic obstructive pulmonary disease.
    7. The Role of Matrix Metalloproteinase-13 (MMP13) in TGFbeta/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
      Title: The Role of Matrix Metalloproteinase-13 (MMP13) in TGFβ/BMP Pathway Regulation of Fibro-Adipogenic Progenitor (FAP) Differentiation.
    8. MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
      Title: MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma.
    9. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
      Title: Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency.
    10. STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
      Title: STAT3 induces breast cancer growth via ANGPTL4, MMP13 and STC1 secretion by cancer associated fibroblasts.
    Submit: New GeneRIF Correction See all GeneRIFs (153)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in bone mineralization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in bone morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in collagen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endochondral ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within growth plate cartilage development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of pancreatic trypsinogen secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to hormone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercellular canaliculus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    collagenase 3
    Names
    collagenase-1
    interstitial collagenase
    matrix metalloproteinase 13
    NP_032633.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008607.2 → NP_032633.1  collagenase 3 preproprotein

      See identical proteins and their annotated locations for NP_032633.1

      Status: REVIEWED

      Source sequence(s)
      AC174457, AK150728, BC125320
      Consensus CDS
      CCDS22803.1
      UniProtKB/Swiss-Prot
      P33435
      UniProtKB/TrEMBL
      Q3U5R7, Q3U9V5
      Related
      ENSMUSP00000015394.9, ENSMUST00000015394.10
      Conserved Domains (4) summary
      cd00094
      Location:282 → 472
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:113 → 268
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:113 → 268
      Peptidase_M10; Matrixin
      pfam01471
      Location:33 → 92
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      7272514..7283333
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33435.1 GenPept UniProtKB/Swiss-Prot:P33435

    Gene LinkOut

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