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    Ttc36 tetratricopeptide repeat domain 36 [ Mus musculus (house mouse) ]

    Gene ID: 192653, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Ttc36provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 36provided by MGI
    Primary source
    MGI:MGI:2384760
    See related
    Ensembl:ENSMUSG00000039438 AllianceGenome:MGI:2384760
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within several processes, including learning or memory; negative regulation of cellular protein metabolic process; and tyrosine metabolic process. Is expressed in cerebral cortex ventricular layer; forelimb bud; genitourinary system; and liver. Orthologous to human TTC36 (tetratricopeptide repeat domain 36). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 842.4), kidney adult (RPKM 543.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A5.2; 9 24.84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44710697..44714248, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44799400..44802951, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene archain 1 Neighboring gene STARR-positive B cell enhancer ABC_E9756 Neighboring gene intraflagellar transport 46 Neighboring gene transmembrane protein 25 Neighboring gene lysine (K)-specific methyltransferase 2A Neighboring gene predicted gene, 39326 Neighboring gene STARR-positive B cell enhancer ABC_E6728 Neighboring gene STARR-seq mESC enhancer starr_23986 Neighboring gene predicted gene, 30883

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A modified TALEN-based strategy for rapidly and efficiently generating knockout mice for kidney development studies. Liu Y, et al. PLoS One, 2014. PMID 24416307, Free PMC Article
    2. The expression patterns of Tetratricopeptide repeat domain 36 (Ttc36). Zhou Y, et al. Gene Expr Patterns, 2016 Nov. PMID 27826126
    3. HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage. Xie Y, et al. Nat Commun, 2019 Sep 19. PMID 31537781, Free PMC Article
    4. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC25970, MGC37247, MGC37838, MGC37912

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of peptidyl-threonine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 36
    Names
    TPR repeat protein 36

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138951.1 → NP_620401.1  tetratricopeptide repeat protein 36

      See identical proteins and their annotated locations for NP_620401.1

      Status: PROVISIONAL

      Source sequence(s)
      BC024432
      Consensus CDS
      CCDS23121.1
      UniProtKB/Swiss-Prot
      Q8VBW8
      Related
      ENSMUSP00000042183.7, ENSMUST00000044694.8
      Conserved Domains (3) summary
      sd00006
      Location:48 → 76
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:82 → 111
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:48 → 112
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      44710697..44714248 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBW8.1 GenPept UniProtKB/Swiss-Prot:Q8VBW8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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