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    Slc37a1 solute carrier family 37 (glycerol-3-phosphate transporter), member 1 [ Mus musculus (house mouse) ]

    Gene ID: 224674, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc37a1provided by MGI
    Official Full Name
    solute carrier family 37 (glycerol-3-phosphate transporter), member 1provided by MGI
    Primary source
    MGI:MGI:2446181
    See related
    Ensembl:ENSMUSG00000024036 AllianceGenome:MGI:2446181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G3PP
    Summary
    Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in brain. Orthologous to human SLC37A1 (solute carrier family 37 member 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 42.5), large intestine adult (RPKM 20.7) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    17 B1; 17 16.03 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31495722..31569683)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31295135..31350709)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene transmembrane protease, serine 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31341993-31342102 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31344766-31345042 Neighboring gene STARR-positive B cell enhancer ABC_E3196 Neighboring gene ubiquitin associated and SH3 domain containing, A Neighboring gene STARR-positive B cell enhancer ABC_E10945 Neighboring gene radial spoke head 1 homolog (Chlamydomonas) Neighboring gene STARR-seq mESC enhancer starr_42328 Neighboring gene predicted gene, 30139 Neighboring gene STARR-seq mESC enhancer starr_42332 Neighboring gene phosphodiesterase 9A Neighboring gene STARR-seq mESC enhancer starr_42334 Neighboring gene predicted gene 9902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31649222-31649405 Neighboring gene STARR-positive B cell enhancer ABC_E3197 Neighboring gene WD repeat domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28167

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A1
    Names
    glycerol-3-phosphate transporter
    solute carrier family 37 member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242427.1 → NP_001229356.1  glucose-6-phosphate exchanger SLC37A1

      See identical proteins and their annotated locations for NP_001229356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK153706, CO039406, CX235981
      Consensus CDS
      CCDS37548.1
      UniProtKB/Swiss-Prot
      Q3UPC2, Q8R070
      UniProtKB/TrEMBL
      Q3TQ11
      Related
      ENSMUSP00000128223.2, ENSMUST00000165149.3
      Conserved Domains (1) summary
      cd17344
      Location:21 → 514
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

    2. NM_153062.2 → NP_694702.1  glucose-6-phosphate exchanger SLC37A1

      See identical proteins and their annotated locations for NP_694702.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC154652
      Consensus CDS
      CCDS37548.1
      UniProtKB/Swiss-Prot
      Q3UPC2, Q8R070
      UniProtKB/TrEMBL
      Q3TQ11
      Related
      ENSMUSP00000126111.2, ENSMUST00000171233.9
      Conserved Domains (1) summary
      cd17344
      Location:21 → 514
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      31495722..31569683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160526.1 → XP_036016419.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

      UniProtKB/Swiss-Prot
      Q3UPC2, Q8R070
      UniProtKB/TrEMBL
      Q3TQ11
      Conserved Domains (1) summary
      cd17344
      Location:21 → 514
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

    2. XM_006524097.5 → XP_006524160.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

      See identical proteins and their annotated locations for XP_006524160.1

      UniProtKB/Swiss-Prot
      Q3UPC2, Q8R070
      UniProtKB/TrEMBL
      Q3TQ11
      Conserved Domains (1) summary
      cd17344
      Location:21 → 514
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

    3. XM_011246396.4 → XP_011244698.1  glucose-6-phosphate exchanger SLC37A1 isoform X1

      See identical proteins and their annotated locations for XP_011244698.1

      UniProtKB/Swiss-Prot
      Q3UPC2, Q8R070
      UniProtKB/TrEMBL
      Q3TQ11
      Related
      ENSMUSP00000157617.2, ENSMUST00000236251.2
      Conserved Domains (1) summary
      cd17344
      Location:21 → 514
      MFS_SLC37A1_2; Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters

    4. XM_006524099.5 → XP_006524162.1  glucose-6-phosphate exchanger SLC37A1 isoform X2

      UniProtKB/TrEMBL
      Q8K0Y8
      Conserved Domains (1) summary
      cl28910
      Location:1 → 322
      MFS; Major Facilitator Superfamily

    5. XM_017317410.3 → XP_017172899.1  glucose-6-phosphate exchanger SLC37A1 isoform X3

      UniProtKB/TrEMBL
      Q8K0Y8
      Conserved Domains (1) summary
      cl28910
      Location:88 → 277
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R070.1 GenPept UniProtKB/Swiss-Prot:Q8R070

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