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    Emc9 ER membrane protein complex subunit 9 [ Mus musculus (house mouse) ]

    Gene ID: 85308, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Emc9provided by MGI
    Official Full Name
    ER membrane protein complex subunit 9provided by MGI
    Primary source
    MGI:MGI:1934682
    See related
    Ensembl:ENSMUSG00000022217 AllianceGenome:MGI:1934682
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgi112; Fam158a; 1500005A01Rik
    Summary
    Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in cytoplasm. Predicted to be part of EMC complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human EMC9 (ER membrane protein complex subunit 9). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 23.3), subcutaneous fat pad adult (RPKM 18.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    14 C3; 14 28.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55818976..55822832, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55581519..55585375, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene ring finger protein 31

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. Yawata M, et al. Immunogenetics, 2001 Mar. PMID 11345588
    2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
    3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ER membrane protein complex subunit 9
    Names
    UPF0172 protein FAM158A
    family with sequence similarity 158, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418787.1 → NP_001405716.1  ER membrane protein complex subunit 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC174678

    2. NM_001418788.1 → NP_001405717.1  ER membrane protein complex subunit 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC174678

    3. NM_001418789.1 → NP_001405718.1  ER membrane protein complex subunit 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC174678
      Related
      ENSMUSP00000133463.2, ENSMUST00000174352.8

    4. NM_001418790.1 → NP_001405719.1  ER membrane protein complex subunit 9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC174678

    5. NM_033146.2 → NP_149158.1  ER membrane protein complex subunit 9 isoform 1

      See identical proteins and their annotated locations for NP_149158.1

      Status: VALIDATED

      Source sequence(s)
      AC174678
      Consensus CDS
      CCDS27117.1
      UniProtKB/Swiss-Prot
      Q9DB76
      UniProtKB/TrEMBL
      Q793L1
      Related
      ENSMUSP00000022828.9, ENSMUST00000022828.9
      Conserved Domains (1) summary
      cd08060
      Location:6 → 188
      MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      55818976..55822832 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158938.1 → XP_036014831.1  ER membrane protein complex subunit 9 isoform X2

      Conserved Domains (1) summary
      pfam03665
      Location:3 → 94
      UPF0172; Uncharacterized protein family (UPF0172)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB76.1 GenPept UniProtKB/Swiss-Prot:Q9DB76

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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