Rnf19a ring finger protein 19A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf19aprovided by MGI
Official Full Name: ring finger protein 19Aprovided by MGI
Primary source: MGI:MGI:1353623
See related: Ensembl:ENSMUSG00000022280 AllianceGenome:MGI:1353623
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: XYbp; Rnf19; Dorfin; UIP117; Ubce7ip2
Summary: Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Is active in glutamatergic synapse and hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; retina; and tooth. Orthologous to human RNF19A (ring finger protein 19A, RBR E3 ubiquitin protein ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 56.1), liver E18 (RPKM 11.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B3.1; 15 14.46 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (36240080..36283293, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (36239934..36283147, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection.
Title: H3K27me3 of Rnf19a promotes neuroinflammatory response during Japanese encephalitis virus infection.
RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.
Title: RNF19a inhibits antiviral immune response to RNA viruses through degradation of TBK1.
These results suggest that Dorfin may regulate adult neurogenesis, synaptic plasticity, and contextual fear memory.
Title: Mice lacking the PSD-95-interacting E3 ligase, Dorfin/Rnf19a, display reduced adult neurogenesis, enhanced long-term potentiation, and impaired contextual fear conditioning.
In addition to causing a decrease in the amount of mutant SOD1 protein in the spinal cord, Dorfin overexpression ameliorated neurological phenotypes and motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis.
Title: Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis.
Dorfin ubiquitylated mutant SOD1 by recognizing the Cys(6)- and Cys(111)-disulfide cross-linked form and targeted it for proteasomal degradation
Title: Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF19A

Names: UBCM4-interacting protein 117; XY body protein; double ring-finger protein; gametogenesis-expressed protein GEG-154; ring finger protein (C3HC4 type) 19; ubiquitin conjugating enzyme 7 interacting protein 2

NP_001344560.1

EC 2.3.2.31

NP_038951.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357631.1 → NP_001344560.1 E3 ubiquitin-protein ligase RNF19A isoform 2

Status: VALIDATED

Source sequence(s)

AC121577, AC147366

Consensus CDS

CCDS88749.1

UniProtKB/TrEMBL

A0A2I3BRK4

Related

ENSMUSP00000154617.2, ENSMUST00000228358.2

Conserved Domains (4) summary

smart00647
Location:199 → 264

IBR; In Between Ring fingers

pfam01485
Location:297 → 335

IBR; IBR domain, a half RING-finger domain

cd16775
Location:131 → 185

RING-HC_RBR_RNF19A; RING finger, HC subclass, found in RING finger protein 19A (RNF19A) and similar proteins

cl00570
Location:361 → 450

AzlC; AzlC protein
NM_013923.2 → NP_038951.1 E3 ubiquitin-protein ligase RNF19A isoform 1

See identical proteins and their annotated locations for NP_038951.1

Status: VALIDATED

Source sequence(s)

AK147768, BY207861, CN695058, CO432840, DV656092

Consensus CDS

CCDS27427.1

UniProtKB/Swiss-Prot

P50636, Q3UGT2, Q9QUJ5

Related

ENSMUSP00000022890.9, ENSMUST00000022890.10

Conserved Domains (4) summary

smart00184
Location:132 → 179

RING; Ring finger

smart00647
Location:199 → 264

IBR; In Between Ring fingers

pfam01485
Location:297 → 335

IBR; IBR domain, a half RING-finger domain

cl00570
Location:361 → 450

AzlC; AzlC protein