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    Khsrp KH-type splicing regulatory protein [ Mus musculus (house mouse) ]

    Gene ID: 16549, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Khsrpprovided by MGI
    Official Full Name
    KH-type splicing regulatory proteinprovided by MGI
    Primary source
    MGI:MGI:1336214
    See related
    Ensembl:ENSMUSG00000007670 AllianceGenome:MGI:1336214
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbp2; Ksrp; Fubp2; 6330409F21Rik
    Summary
    Enables mRNA binding activity. Acts upstream of or within mRNA catabolic process and regulation of miRNA metabolic process. Located in cytoplasmic stress granule. Is expressed in gonad; pancreas tip epithelium; and urinary system. Orthologous to human KHSRP (KH-type splicing regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 54.0), thymus adult (RPKM 53.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Khsrp in Genome Data Viewer
    Location:
    17 D; 17 29.63 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (57328049..57338507, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (57021049..57031507, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF, polypeptide 1 Neighboring gene STARR-positive B cell enhancer ABC_E492 Neighboring gene adenylate kinase 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E142 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:57171392-57171575 Neighboring gene solute carrier family 25, member 41 Neighboring gene solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization. Olguin SL, et al. Commun Biol, 2022 Jul 7. PMID 35798971, Free PMC Article
    2. Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice. Li N, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29222050
    3. Inactivation of the KSRP gene modifies collagen antibody induced arthritis. Käfer R, et al. Mol Immunol, 2017 Jul. PMID 28511090
    4. Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity. Bollmann F, et al. Nucleic Acids Res, 2014 Nov 10. PMID 25352548, Free PMC Article
    5. KSRP silencing favors neural differentiation of P19 teratocarcinoma cells. Giovarelli M, et al. Biochim Biophys Acta, 2013 May. PMID 23462617

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KSRP improves pancreatic beta cell function and survival.
      Title: KSRP improves pancreatic beta cell function and survival.
    2. KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.
      Title: KHSRP loss increases neuronal growth and synaptic transmission and alters memory consolidation through RNA stabilization.
    3. Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice.
      Title: Knockout of the KH-Type Splicing Regulatory Protein Drives Glomerulonephritis in MRL-Fas(lpr) Mice.
    4. FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
      Title: FUBP1 and FUBP2 enforce distinct epigenetic setpoints for MYC expression in primary single murine cells.
    5. The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
      Title: The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
    6. Report KSRP/mRNA/microRNA interactions in chromatoid body of spermatids regulating spermatogenesis.
      Title: KH-type splicing regulatory protein is a new component of chromatoid body.
    7. CXCL-2 and HMOX-1 were upregulated in H. pylori infection after KSRP overexpression. This difference in expression of these genes implicated that KSRP was closely associated with and directly participated in the innate immune response against H. pylori.
      Title: Effects of the RNA-binding protein, KSRP, on innate immune response against Helicobacter pylori infection in mice.
    8. IFN-gamma production was increased in spleen cells of KSRP(-/-) mice.
      Title: Inactivation of the KSRP gene modifies collagen antibody induced arthritis.
    9. Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1.
      Title: Resveratrol limits epithelial to mesenchymal transition through modulation of KHSRP/hnRNPA1-dependent alternative splicing in mammary gland cells.
    10. KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression
      Title: KSRP is critical in governing hepatic lipid metabolism through controlling Per2 expression.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (6) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to cytokine stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in miRNA metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of low-density lipoprotein particle clearance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nitric oxide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of mRNA stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of miRNA metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    far upstream element-binding protein 2
    Names
    FUSE-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010613.3 → NP_034743.3  far upstream element-binding protein 2

      See identical proteins and their annotated locations for NP_034743.3

      Status: VALIDATED

      Source sequence(s)
      BB258658, BB645370, BC108414, CB247078
      Consensus CDS
      CCDS50157.1
      UniProtKB/Swiss-Prot
      E9QKH3, Q2VPQ6, Q3U0V1, Q6P2L2
      UniProtKB/TrEMBL
      A0A3B2WCD8
      Related
      ENSMUSP00000007814.9, ENSMUST00000007814.10
      Conserved Domains (3) summary
      cd00105
      Location:147 → 209
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam00013
      Location:427 → 492
      KH_1; KH domain
      pfam09005
      Location:672 → 686
      DUF1897; Domain of unknown function (DUF1897)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      57328049..57338507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3U0V1.2 GenPept UniProtKB/Swiss-Prot:Q3U0V1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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