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    Cluap1 clusterin associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76779, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cluap1provided by MGI
    Official Full Name
    clusterin associated protein 1provided by MGI
    Primary source
    MGI:MGI:1924029
    See related
    Ensembl:ENSMUSG00000014232 AllianceGenome:MGI:1924029
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310030D15Rik; 2610111M03Rik
    Summary
    Acts upstream of or within several processes, including axoneme assembly; embryonic morphogenesis; and left/right pattern formation. Located in centrosome; ciliary base; and ciliary tip. Part of intraciliary transport particle A and intraciliary transport particle B. Is expressed in several structures, including cranial ganglion; neural tube; olfactory epithelium; respiratory system; and thymus primordium. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 9.6), CNS E18 (RPKM 6.3) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cluap1 in Genome Data Viewer
    Location:
    16 A1; 16 2.3 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (3725058..3760163)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (3907194..3942299)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5522 Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene zinc finger protein 174 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872304-3872526 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3872697-3872880 Neighboring gene zinc finger protein 597 Neighboring gene STARR-positive B cell enhancer mm9_chr16:3884448-3884748 Neighboring gene N(alpha)-acetyltransferase 60, NatF catalytic subunit Neighboring gene RIKEN cDNA 1700037C18 gene Neighboring gene predicted gene, 41410 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3908535-3908837 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3909019-3909128 Neighboring gene prothymosin alpha-like Neighboring gene predicted gene 15539 Neighboring gene predicted gene, 57636 Neighboring gene NLR family, CARD domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:3976439-3976665 Neighboring gene SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ciliogenesis-coupled accumulation of IFT-B proteins in a novel cytoplasmic compartment. Lamri L, et al. Genes Cells, 2019 Nov. PMID 31554018
    2. Human cilia proteome contains homolog of zebrafish polycystic kidney disease gene qilin. Marshall WF. Curr Biol, 2004 Nov 9. PMID 15530380
    3. Mammalian Clusterin associated protein 1 is an evolutionarily conserved protein required for ciliogenesis. Pasek RC, et al. Cilia, 2012 Nov 1. PMID 23351563, Free PMC Article
    4. TRIP6 functions in brain ciliogenesis. Shukla S, et al. Nat Commun, 2021 Oct 7. PMID 34620853, Free PMC Article
    5. Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo. Botilde Y, et al. Dev Biol, 2013 Sep 1. PMID 23742838

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a ciliogenesis defect of Cluap1-deficient embryonic fibroblasts was rescued by exogenous expression of wild-type Cluap1 but not by mutant Cluap1 lacking the binding ability to other IFT-B components
      Title: Overall Architecture of the Intraflagellar Transport (IFT)-B Complex Containing Cluap1/IFT38 as an Essential Component of the IFT-B Peripheral Subcomplex.
    2. Cluap1 contributes to ciliogenesis by regulating the intraflagellar transport cycle at the base and tip of the cilium
      Title: Cluap1 localizes preferentially to the base and tip of cilia and is required for ciliogenesis in the mouse embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell projection organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cilium assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within floor plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart looping IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intraciliary anterograde transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within intraciliary transport IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within left/right pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ciliary tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cilium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of intraciliary transport particle A IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of intraciliary transport particle B ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    clusterin-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419018.1 → NP_001405947.1  clusterin-associated protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129021

    2. NM_001419019.1 → NP_001405948.1  clusterin-associated protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129021

    3. NM_001419020.1 → NP_001405949.1  clusterin-associated protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC129021

    4. NM_001419021.1 → NP_001405950.1  clusterin-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC129021

    5. NM_001419022.1 → NP_001405951.1  clusterin-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC129021

    6. NM_001419023.1 → NP_001405952.1  clusterin-associated protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC129021

    7. NM_001419024.1 → NP_001405953.1  clusterin-associated protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC129021

    8. NM_001419025.1 → NP_001405954.1  clusterin-associated protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC129021

    9. NM_001419026.1 → NP_001405955.1  clusterin-associated protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC129021

    10. NM_001419027.1 → NP_001405956.1  clusterin-associated protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC129021

    11. NM_001419028.1 → NP_001405957.1  clusterin-associated protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC129021

    12. NM_029738.3 → NP_084014.1  clusterin-associated protein 1 isoform 1

      See identical proteins and their annotated locations for NP_084014.1

      Status: VALIDATED

      Source sequence(s)
      AC129021
      Consensus CDS
      CCDS27912.1
      UniProtKB/Swiss-Prot
      Q6P3Y8, Q8R3P7
      Related
      ENSMUSP00000043397.8, ENSMUST00000040881.14
      Conserved Domains (2) summary
      pfam10234
      Location:19 → 278
      Cluap1; Clusterin-associated protein-1
      cl23887
      Location:182 → 308
      DUF4349; Domain of unknown function (DUF4349)

    RNA

    1. NR_185001.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129021

    2. NR_185002.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC129021

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      3725058..3760163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317157.2 → XP_017172646.2  clusterin-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam10234
      Location:111 → 370
      Cluap1; Clusterin-associated protein-1

    2. XM_006522701.5 → XP_006522764.5  clusterin-associated protein 1 isoform X2

      Conserved Domains (1) summary
      pfam10234
      Location:57 → 326
      Cluap1; Clusterin-associated protein-1

    3. XM_006522702.4 → XP_006522765.1  clusterin-associated protein 1 isoform X3

      Conserved Domains (1) summary
      pfam10234
      Location:20 → 279
      Cluap1; Clusterin-associated protein-1

    4. XM_006522704.5 → XP_006522767.1  clusterin-associated protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006522767.1

      Conserved Domains (1) summary
      pfam10234
      Location:8 → 267
      Cluap1; Clusterin-associated protein-1

    5. XM_006522705.5 → XP_006522768.1  clusterin-associated protein 1 isoform X5

      See identical proteins and their annotated locations for XP_006522768.1

      Conserved Domains (1) summary
      pfam10234
      Location:8 → 267
      Cluap1; Clusterin-associated protein-1

    6. XM_030249328.2 → XP_030105188.1  clusterin-associated protein 1 isoform X7

      Conserved Domains (1) summary
      pfam10234
      Location:3 → 272
      Cluap1; Clusterin-associated protein-1

    7. XM_006522706.4 → XP_006522769.1  clusterin-associated protein 1 isoform X8

      Conserved Domains (1) summary
      pfam10234
      Location:1 → 94
      Cluap1; Clusterin-associated protein-1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R3P7.1 GenPept UniProtKB/Swiss-Prot:Q8R3P7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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