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    Tmem135 transmembrane protein 135 [ Mus musculus (house mouse) ]

    Gene ID: 72759, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Tmem135provided by MGI
    Official Full Name
    transmembrane protein 135provided by MGI
    Primary source
    MGI:MGI:1920009
    See related
    Ensembl:ENSMUSG00000039428 AllianceGenome:MGI:1920009
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PMP52; 2810439K08Rik
    Summary
    Involved in regulation of mitochondrial fission. Acts upstream of or within response to cold and response to food. Located in lipid droplet; mitochondrion; and peroxisome. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 32.4), subcutaneous fat pad adult (RPKM 19.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 D3; 7 49.32 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (88789230..89053911, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89140022..89404703, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19485 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 6240 Neighboring gene STARR-seq mESC enhancer starr_19487 Neighboring gene STARR-positive B cell enhancer ABC_E11359 Neighboring gene STARR-positive B cell enhancer ABC_E10449 Neighboring gene STARR-seq mESC enhancer starr_19488 Neighboring gene STARR-positive B cell enhancer ABC_E4946 Neighboring gene STARR-seq mESC enhancer starr_19489 Neighboring gene STARR-seq mESC enhancer starr_19490 Neighboring gene expressed sequence AI314278 Neighboring gene frizzled class receptor 4 Neighboring gene serine protease 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
      Title: TMEM135 maintains the equilibrium of osteogenesis and adipogenesis by regulating mitochondrial dynamics.
    2. TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
      Title: TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis.
    3. Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
      Title: Transmembrane protein 135 regulates lipid homeostasis through its role in peroxisomal DHA metabolism.
    4. A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
      Title: A mutation in transmembrane protein 135 impairs lipid metabolism in mouse eyecups.
    5. Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
      Title: Modulation of Tmem135 Leads to Retinal Pigmented Epithelium Pathologies in Mice.
    6. Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
      Title: Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.
    7. The authors observed localization of TMEM135 on mitochondria, and imbalance of mitochondrial fission and fusion in mutant Tmem135 as well as Tmem135 overexpressing cells, indicating that TMEM135 is involved in the regulation of mitochondrial dynamics.
      Title: Mouse Tmem135 mutation reveals a mechanism involving mitochondrial dynamics that leads to age-dependent retinal pathologies.
    8. TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms
      Title: Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of adult lifespan ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of lipid storage ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of mitochondrial fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within retinal pigment epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 135
    Names
    peroxisomal membrane protein 52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360745.1 → NP_001347674.1  transmembrane protein 135 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC116659, AC122386, AC123844
      Conserved Domains (1) summary
      pfam02466
      Location:160 → 212
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    2. NM_001360746.1 → NP_001347675.1  transmembrane protein 135 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' end and lacks an alternate exon compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AC116326, AC116659, AC122386, AC123844
      Conserved Domains (1) summary
      pfam02466
      Location:160 → 212
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    3. NM_028343.5 → NP_082619.3  transmembrane protein 135 isoform a

      See identical proteins and their annotated locations for NP_082619.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC116659, AC122386, AK013269
      Consensus CDS
      CCDS21440.1
      UniProtKB/Swiss-Prot
      Q8BSY5, Q8CCZ6, Q8CE78, Q9CYV5
      Related
      ENSMUSP00000042783.4, ENSMUST00000041968.11
      Conserved Domains (2) summary
      pfam02466
      Location:249 → 338
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
      pfam15982
      Location:9 → 142
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      88789230..89053911 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241911.2 → XP_011240213.1  transmembrane protein 135 isoform X2

      Conserved Domains (2) summary
      pfam02466
      Location:280 → 332
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
      pfam15982
      Location:29 → 123
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

    2. XM_036153464.1 → XP_036009357.1  transmembrane protein 135 isoform X3

      Conserved Domains (1) summary
      pfam02466
      Location:171 → 223
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    3. XM_030243017.2 → XP_030098877.1  transmembrane protein 135 isoform X3

      Conserved Domains (1) summary
      pfam02466
      Location:171 → 223
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    4. XM_036153466.1 → XP_036009359.1  transmembrane protein 135 isoform X5

      Conserved Domains (1) summary
      pfam02466
      Location:160 → 212
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    5. XM_036153465.1 → XP_036009358.1  transmembrane protein 135 isoform X4

      Conserved Domains (1) summary
      pfam02466
      Location:164 → 216
      Tim17; Tim17/Tim22/Tim23/Pmp24 family

    6. XM_030243016.2 → XP_030098876.1  transmembrane protein 135 isoform X1

      Conserved Domains (2) summary
      pfam02466
      Location:384 → 436
      Tim17; Tim17/Tim22/Tim23/Pmp24 family
      pfam15982
      Location:130 → 227
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135

    7. XM_030243018.2 → XP_030098878.1  transmembrane protein 135 isoform X6

      Conserved Domains (1) summary
      pfam15982
      Location:130 → 227
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYV5.1 GenPept UniProtKB/Swiss-Prot:Q9CYV5

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