U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Ndufs1 NADH:ubiquinone oxidoreductase core subunit S1 [ Mus musculus (house mouse) ]

    Gene ID: 227197, updated on 5-Mar-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ndufs1provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase core subunit S1provided by MGI
    Primary source
    MGI:MGI:2443241
    See related
    Ensembl:ENSMUSG00000025968 AllianceGenome:MGI:2443241
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830412M15Rik; 9930026A05Rik
    Summary
    Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in inherited metabolic disorder; mitochondrial complex I deficiency; and nuclear type mitochondrial complex I deficiency 5. Orthologous to human NDUFS1 (NADH:ubiquinone oxidoreductase core subunit S1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 78.5), cerebellum adult (RPKM 29.7) and 22 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    1 C2; 1 32.29 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (63182751..63215981, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (63143592..63176822, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24942 Neighboring gene INO80 complex subunit D Neighboring gene ribosomal protein S27, pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2545 Neighboring gene STARR-seq mESC enhancer starr_01125 Neighboring gene INO80 complex subunit D, opposite strand Neighboring gene STARR-seq mESC enhancer starr_01129 Neighboring gene STARR-positive B cell enhancer ABC_E1994 Neighboring gene predicted gene, 26457 Neighboring gene small nucleolar RNA, H/ACA box 41 Neighboring gene eukaryotic translation elongation factor 1 beta 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis. Qi B, et al. Exp Mol Med, 2022 Jul. PMID 35817848, Free PMC Article
    2. Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy. Zou R, et al. Oxid Med Cell Longev, 2021. PMID 33763166, Free PMC Article
    3. Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Lopez-Fabuel I, et al. Proc Natl Acad Sci U S A, 2016 Nov 15. PMID 27799543, Free PMC Article
    4. Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia. Gorenkova N, et al. Antioxid Redox Signal, 2013 Nov 1. PMID 23419200, Free PMC Article
    5. Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes. Choksi KB, et al. Free Radic Biol Med, 2008 Sep 15. PMID 18598756, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis.
      Title: Cardiac-specific overexpression of Ndufs1 ameliorates cardiac dysfunction after myocardial infarction by alleviating mitochondrial dysfunction and apoptosis.
    2. Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy.
      Title: Ndufs1 Deficiency Aggravates the Mitochondrial Membrane Potential Dysfunction in Pressure Overload-Induced Myocardial Hypertrophy.
    3. The transition of mitochondrial complex I into the D-form in the absence of oxygen may represent a key event in promoting cardiac injury during I/R.
      Title: Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia.
    4. lysosomal membrane permeability induced by TNFalpha plus cycloheximide, the release of lysosomal cathepsins and reactive oxygen species formation require the caspase-3-mediated cleavage of the p75 NDUFS1 subunit of respiratory complex I.
      Title: TNFα-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC7850, MGC19199

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase (ubiquinone) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables electron transfer activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP synthesis coupled electron transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in apoptotic mitochondrial changes ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular respiration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myelin sheath HDA PubMed 
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
    Names
    CI-75kD
    NADH dehydrogenase (ubiquinone) Fe-S protein 1
    complex I-75kD
    NP_001153510.1
    NP_001153511.1
    NP_001153512.1
    NP_663493.2
    XP_006496015.1
    XP_030109554.1
    XP_036020306.1
    XP_036020310.1
    XP_036020314.1
    XP_036020318.1
    XP_036020320.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160038.1 → NP_001153510.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001153510.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AK036926, AV444601, BU708393, BY709888
      Consensus CDS
      CCDS14996.1
      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    2. NM_001160039.1 → NP_001153511.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001153511.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK036926, AV444601, BY709888, CN715066
      Consensus CDS
      CCDS14996.1
      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    3. NM_001160040.1 → NP_001153512.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001153512.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK036926, AV444601, BG808119, BY709888
      Consensus CDS
      CCDS14996.1
      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Related
      ENSMUSP00000126621.3, ENSMUST00000168099.9
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    4. NM_145518.2 → NP_663493.2  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663493.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK036926, AV444601, BY709888
      Consensus CDS
      CCDS14996.1
      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Related
      ENSMUSP00000027111.9, ENSMUST00000027111.15
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      63182751..63215981 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495952.4 → XP_006496015.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006496015.1

      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    2. XM_036164427.1 → XP_036020320.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:1 → 580
      PRK09130; NADH dehydrogenase subunit G; Validated

    3. XM_030253694.2 → XP_030109554.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    4. XM_036164417.1 → XP_036020310.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    5. XM_036164421.1 → XP_036020314.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated

    6. XM_036164425.1 → XP_036020318.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:1 → 580
      PRK09130; NADH dehydrogenase subunit G; Validated

    7. XM_036164413.1 → XP_036020306.1  NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q3UQ73, Q8BM16, Q91VD9
      UniProtKB/TrEMBL
      Q3TIU7, Q3UIQ2
      Conserved Domains (1) summary
      PRK09130
      Location:31 → 723
      PRK09130; NADH dehydrogenase subunit G; Validated
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VD9.2 GenPept UniProtKB/Swiss-Prot:Q91VD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous