Akr1c20 aldo-keto reductase family 1, member C20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1c20provided by MGI
Official Full Name: aldo-keto reductase family 1, member C20provided by MGI
Primary source: MGI:MGI:2151104
See related: Ensembl:ENSMUSG00000054757 AllianceGenome:MGI:2151104
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2610528B18Rik
Summary: Predicted to enable several functions, including oxidoreductase activity, acting on CH-OH group of donors; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including glycoside metabolic process; progesterone metabolic process; and prostaglandin metabolic process. Predicted to act upstream of or within steroid biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in 46,XY sex reversal 8; B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to several human genes including AKR1C1 (aldo-keto reductase family 1 member C1); AKR1C2 (aldo-keto reductase family 1 member C2); and AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 7.9), liver E18 (RPKM 4.0) and 1 other tissue See more
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Genomic context

Location:: 13 A1; 13 2.51 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (4536855..4573353, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (4486856..4523354, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKR1C20 is a novel 3alpha(17beta-hydroxysteroid dehydrogenase, which may also function as a reductase for xenobiotic alpha-dicarbonyl compounds
Title: Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISA Inferred from Sequence Alignment more info	PubMed
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase (B-specific) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid binding	ISO Inferred from Sequence Orthology more info
enables carboxylic acid binding	ISO Inferred from Sequence Orthology more info
enables chlordecone reductase activity	ISO Inferred from Sequence Orthology more info
enables delta4-3-oxosteroid 5beta-reductase activity	ISO Inferred from Sequence Orthology more info
enables dihydrotestosterone 17-beta-dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables ketoreductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables phenanthrene 9,10-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables testosterone 17-beta-dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticosteroid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within steroid biosynthetic process	ISA Inferred from Sequence Alignment more info	PubMed
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1, member C20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311132.1 → NP_001298061.1 aldo-keto reductase family 1, member C20

See identical proteins and their annotated locations for NP_001298061.1

Status: VALIDATED

Source sequence(s)

AC166056, AI661346, AK012162

Consensus CDS

CCDS79161.1

UniProtKB/TrEMBL

A0A1Y7VMC8, Q8VC77

Related

ENSMUSP00000079232.6, ENSMUST00000080361.13

Conserved Domains (2) summary

COG0656
Location:5 → 317

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:16 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

4536855..4573353 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247130.1 → XP_030102990.1 aldo-keto reductase family 1, member C20 isoform X3

UniProtKB/TrEMBL

A0A1Y7VMC8

Conserved Domains (1) summary

cl00470
Location:6 → 259

AKR_SF; Aldo-keto reductase (AKR) superfamily
XM_006516466.1 → XP_006516529.1 aldo-keto reductase family 1, member C20 isoform X2

UniProtKB/TrEMBL

A0A1Y7VMC8

Related

ENSMUSP00000152648.2, ENSMUST00000221564.2

Conserved Domains (1) summary

cd19108
Location:6 → 279

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)
XM_006516465.1 → XP_006516528.1 aldo-keto reductase family 1, member C20 isoform X1

UniProtKB/TrEMBL

A0A1Y7VMC8

Conserved Domains (1) summary

cd19108
Location:6 → 286

AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_054080.1: Suppressed sequence

Description

NM_054080.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.