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    Prss39 serine protease 39 [ Mus musculus (house mouse) ]

    Gene ID: 21755, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Prss39provided by MGI
    Official Full Name
    serine protease 39provided by MGI
    Primary source
    MGI:MGI:1270856
    See related
    Ensembl:ENSMUSG00000026125 AllianceGenome:MGI:1270856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tesp1
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasmic vesicle and extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 299.9) See more
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    Genomic context

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    Location:
    1 B; 1 13.29 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34537493..34542143)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34498412..34503062)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 18 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene 28417 Neighboring gene predicted gene, 32566 Neighboring gene serine protease 40 Neighboring gene predicted gene 28419 Neighboring gene cryptic, EGF-CFC family member 1 Neighboring gene regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome. Ramachandran SS, et al. Mol Hum Reprod, 2021 Sep 29. PMID 34524424
    2. Two novel testicular serine proteases, TESP1 and TESP2, are present in the mouse sperm acrosome. Kohno N, et al. Biochem Biophys Res Commun, 1998 Apr 28. PMID 9588171
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome.
      Title: A mouse testis serine protease, TESP1, as the potential SPINK3 receptor protein on mouse sperm acrosome.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144580, MGC144581

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    inactive serine protease 39
    Names
    inactive testicular serine protease 1
    protease, serine 39
    testicular serine protease 1
    NP_001347784.1
    NP_033381.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360855.1 → NP_001347784.1  inactive serine protease 39 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC106841
      Conserved Domains (1) summary
      cd00190
      Location:3 → 173
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_009355.3 → NP_033381.1  inactive serine protease 39 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033381.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC106841, BC049616, BY716157
      Consensus CDS
      CCDS14868.1
      UniProtKB/Swiss-Prot
      O70169, Q80YD5
      Related
      ENSMUSP00000027299.4, ENSMUST00000027299.10
      Conserved Domains (2) summary
      smart00020
      Location:67 → 307
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:68 → 310
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      34537493..34542143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70169.1 GenPept UniProtKB/Swiss-Prot:O70169

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