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    Pus10 pseudouridylate synthase 10 [ Mus musculus (house mouse) ]

    Gene ID: 74467, updated on 12-May-2024

    Summary

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    Official Symbol
    Pus10provided by MGI
    Official Full Name
    pseudouridylate synthase 10provided by MGI
    Primary source
    MGI:MGI:1921717
    See related
    Ensembl:ENSMUSG00000020280 AllianceGenome:MGI:1921717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc139; 2810013G11Rik; 4933435A13Rik
    Summary
    Predicted to enable primary miRNA binding activity and tRNA pseudouridine synthase activity. Predicted to be involved in primary miRNA processing and tRNA pseudouridine synthesis. Predicted to act upstream of or within tRNA processing. Predicted to be located in cytoplasm and nucleus. Orthologous to human PUS10 (pseudouridine synthase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 5.9), placenta adult (RPKM 5.2) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pus10 in Genome Data Viewer
    Location:
    11 A3.2; 11 14.34 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (23608588..23682876)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (23658591..23732876)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28917 Neighboring gene selenoprotein K, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR Neighboring gene peroxisomal biogenesis factor 13 Neighboring gene STARR-seq mESC enhancer starr_28923 Neighboring gene reticuloendotheliosis oncogene Neighboring gene STARR-seq mESC enhancer starr_28924 Neighboring gene predicted gene, 39612

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables pseudouridine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA pseudouridine(55) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in primary miRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pseudouridine synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA pseudouridine synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA pseudouridine synthesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA pseudouridine synthase Pus10
    Names
    coiled-coil domain containing 139
    coiled-coil domain-containing protein 139
    psi55 synthase
    putative tRNA pseudouridine synthase Pus10
    tRNA pseudouridine 55 synthase
    tRNA pseudouridylate synthase
    tRNA-uridine isomerase
    NP_001028826.1
    NP_001388067.1
    NP_001388068.1
    NP_001388069.1
    NP_001388070.1
    NP_001388071.1
    NP_001388072.1
    NP_001388073.1
    NP_001388074.1
    NP_001388075.1
    NP_001388076.1
    NP_001388077.1
    NP_001388078.1
    NP_001388079.1
    NP_082580.1
    NP_083232.1
    XP_006514925.1
    XP_006514926.1
    XP_006514927.1
    XP_006514928.2
    XP_006514929.1
    XP_030102254.1
    XP_030102260.1
    XP_036012942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033654.3 → NP_001028826.1  tRNA pseudouridine synthase Pus10 isoform 1

      See identical proteins and their annotated locations for NP_001028826.1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      Consensus CDS
      CCDS24479.1
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
      Related
      ENSMUSP00000105151.2, ENSMUST00000109525.8
      Conserved Domains (1) summary
      cl28383
      Location:286 → 521
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    2. NM_001401138.1 → NP_001388067.1  tRNA pseudouridine synthase Pus10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

    3. NM_001401139.1 → NP_001388068.1  tRNA pseudouridine synthase Pus10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

    4. NM_001401140.1 → NP_001388069.1  tRNA pseudouridine synthase Pus10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0

    5. NM_001401141.1 → NP_001388070.1  tRNA pseudouridine synthase Pus10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    6. NM_001401142.1 → NP_001388071.1  tRNA pseudouridine synthase Pus10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    7. NM_001401143.1 → NP_001388072.1  tRNA pseudouridine synthase Pus10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    8. NM_001401144.1 → NP_001388073.1  tRNA pseudouridine synthase Pus10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL805916, BX255874

    9. NM_001401145.1 → NP_001388074.1  tRNA pseudouridine synthase Pus10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL805916, BX255874

    10. NM_001401146.1 → NP_001388075.1  tRNA pseudouridine synthase Pus10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL805916, BX255874

    11. NM_001401147.1 → NP_001388076.1  tRNA pseudouridine synthase Pus10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    12. NM_001401148.1 → NP_001388077.1  tRNA pseudouridine synthase Pus10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    13. NM_001401149.1 → NP_001388078.1  tRNA pseudouridine synthase Pus10 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL805916, BX255874

    14. NM_001401150.1 → NP_001388079.1  tRNA pseudouridine synthase Pus10 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL805916, BX255874

    15. NM_028304.4 → NP_082580.1  tRNA pseudouridine synthase Pus10 isoform 1

      See identical proteins and their annotated locations for NP_082580.1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      Consensus CDS
      CCDS24479.1
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
      Related
      ENSMUSP00000050395.5, ENSMUST00000058163.11
      Conserved Domains (1) summary
      cl28383
      Location:286 → 521
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    16. NM_028956.5 → NP_083232.1  tRNA pseudouridine synthase Pus10 isoform 1

      See identical proteins and their annotated locations for NP_083232.1

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874
      Consensus CDS
      CCDS24479.1
      UniProtKB/Swiss-Prot
      Q3UM90, Q8BSZ4, Q8CDM2, Q9CSI7, Q9D3U0
      Related
      ENSMUSP00000020520.5, ENSMUST00000020520.11
      Conserved Domains (1) summary
      cl28383
      Location:286 → 521
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    RNA

    1. NR_156455.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL672049, AL805916, BX255874

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      23608588..23682876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246400.2 → XP_030102260.1  tRNA pseudouridine synthase Pus10 isoform X5

    2. XM_006514865.5 → XP_006514928.2  tRNA pseudouridine synthase Pus10 isoform X1

      Conserved Domains (1) summary
      cl28383
      Location:437 → 685
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    3. XM_030246394.2 → XP_030102254.1  tRNA pseudouridine synthase Pus10 isoform X2

      Conserved Domains (1) summary
      cl28383
      Location:437 → 684
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    4. XM_006514862.4 → XP_006514925.1  tRNA pseudouridine synthase Pus10 isoform X3

      See identical proteins and their annotated locations for XP_006514925.1

      Conserved Domains (1) summary
      cl28383
      Location:286 → 534
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    5. XM_006514864.3 → XP_006514927.1  tRNA pseudouridine synthase Pus10 isoform X3

      See identical proteins and their annotated locations for XP_006514927.1

      Conserved Domains (1) summary
      cl28383
      Location:286 → 534
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    6. XM_006514863.3 → XP_006514926.1  tRNA pseudouridine synthase Pus10 isoform X3

      See identical proteins and their annotated locations for XP_006514926.1

      Conserved Domains (1) summary
      cl28383
      Location:286 → 534
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    7. XM_006514866.4 → XP_006514929.1  tRNA pseudouridine synthase Pus10 isoform X3

      See identical proteins and their annotated locations for XP_006514929.1

      Conserved Domains (1) summary
      cl28383
      Location:286 → 534
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    8. XM_036157049.1 → XP_036012942.1  tRNA pseudouridine synthase Pus10 isoform X7

      Conserved Domains (1) summary
      cl28383
      Location:122 → 357
      Pus10; tRNA U54 and U55 pseudouridine synthase Pus10 [Translation, ribosomal structure and biogenesis]

    RNA

    1. XR_003949523.2 RNA Sequence

    2. XR_003949522.2 RNA Sequence

    3. XR_003949520.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D3U0.1 GenPept UniProtKB/Swiss-Prot:Q9D3U0

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