Grid2ip glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grid2ipprovided by MGI
Official Full Name: glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein 1provided by MGI
Primary source: MGI:MGI:2176213
See related: Ensembl:ENSMUSG00000010825 AllianceGenome:MGI:2176213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within long-term synaptic depression. Located in dendritic spine. Orthologous to human GRID2IP (Grid2 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 7.6), frontal lobe adult (RPKM 1.2) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 82.1 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (143343085..143377534)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (143357330..143391779)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings are compatible with the idea that LTD induction at PF-PC synapses is a crucial rate-limiting step in optokinetic resonse gain-increase adaptation, a simple form of motor learning
Title: Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin.
A direct link exists between GluR2delta receptor and stimulation of the autophagic pathway in dying Purkinje cells of lurcher mice.
Title: A novel protein complex linking the delta 2 glutamate receptor and autophagy: implications for neurodegeneration in lurcher mice.
Results show that the Delphilin protein exhibits diversity at its N-terminus by variable usage of the first several exons.
Title: Identification and characterization of a novel Delphilin variant with an alternative N-terminus.
Absence of GRID2 receptors in heteroallelic mutants induces an early and massive Purkinje cell death that is correlated with early signs of autophagy and is independent of depolarization.
Title: Lurcher GRID2-induced death and depolarization can be dissociated in cerebellar Purkinje cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cerebellar granule cell to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in cerebellar granule cell to Purkinje cell synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: delphilin

Names: GluR-delta2 philic-protein; L-delphilin; glutamate receptor, ionotropic, delta 2-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159321.2 → NP_001152793.1 delphilin isoform 1

See identical proteins and their annotated locations for NP_001152793.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the larger isoform (1).

Source sequence(s)

AC118226, DQ193535

Consensus CDS

CCDS51689.1

UniProtKB/Swiss-Prot

Q0QWG9, Q6DID0, Q9ESJ5

Related

ENSMUSP00000106361.3, ENSMUST00000110733.9

Conserved Domains (4) summary

cd00992
Location:269 → 342

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd07354
Location:122 → 201

HN_L-delphilin-R1_like; first harmonin_N_like domain (repeat 1) of L-delphilin, and related domains

cd07355
Location:378 → 457

HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains

pfam02181
Location:812 → 1180

FH2; Formin Homology 2 Domain
NM_001347529.2 → NP_001334458.1 delphilin isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) has an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC118226

Consensus CDS

CCDS84992.1

UniProtKB/Swiss-Prot

Q0QWG9

Related

ENSMUSP00000113443.2, ENSMUST00000120825.2
NM_133355.2 → NP_579933.1 delphilin isoform 2

See identical proteins and their annotated locations for NP_579933.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AF099933

Consensus CDS

CCDS19841.1

UniProtKB/Swiss-Prot

Q0QWG9

Related

ENSMUSP00000010969.9, ENSMUST00000010969.15

Conserved Domains (3) summary

cd00992
Location:90 → 163

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd07355
Location:199 → 278

HN_L-delphilin-R2_like; second harmonin_N_like domain (repeat 2) of L-delphilin, and related domains

pfam02181
Location:633 → 1001

FH2; Formin Homology 2 Domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

143343085..143377534

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001038019.1: Suppressed sequence

Description

NM_001038019.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.