Chst15 carbohydrate sulfotransferase 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chst15provided by MGI
Official Full Name: carbohydrate sulfotransferase 15provided by MGI
Primary source: MGI:MGI:1924840
See related: Ensembl:ENSMUSG00000030930 AllianceGenome:MGI:1924840
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BRAG; MAd5; mKIAA0598; GalNAcS-6ST; GalNAc4S-6ST; 4631426J05Rik
Summary: Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate binding activity and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Predicted to be involved in hexose biosynthetic process. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; appendicular skeleton; central nervous system; genitourinary system; and sensory organ. Orthologous to human CHST15 (carbohydrate sulfotransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 9.8), kidney adult (RPKM 5.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F3; 7 76.29 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (131837508..131919227, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (132235779..132323534, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice.
Title: Silencing of tumoral carbohydrate sulfotransferase 15 reactivates lymph node pancreatic cancer T cells in mice.
Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.
Title: Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice.
blockade CHST15 represses colonic fibrosis
Title: Pivotal Role of Carbohydrate Sulfotransferase 15 in Fibrosis and Mucosal Healing in Mouse Colitis.
GalNAc4S-6ST play a crucial role in pulmonary metastasis at least through the increased adhesion and the invasive capacity of LLC cells and also provides insights into future drug targets for anticancer treatment.
Title: Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis.
In GalNacS-6ST knockout mice chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues disappear completely.
Title: Mice deficient in N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase are unable to synthesize chondroitin/dermatan sulfate containing N-acetylgalactosamine 4,6-bissulfate residues and exhibit decreased protease activity in bone marrow-derived mast cells.
expression of the Serglycincore protein, chondroitin 4-sulfotransferase (C4ST)-1, and GalNAc(4S)-6-O-sulfotransferase (GalNAc4S6ST) are closely linked to mast cell maturation
Title: Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases.
analysis of the three CS sulfotransferases in the developing neocortex: uronyl 2-O-sulfotransferase (UST), N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase (4,6-ST) and dermatan 4-O-sulfotransferase-1 (D4-ST)
Title: Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex.
GalNAc4S-6ST has a role during early mouse development
Title: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

4631426J05Rik (e-PCR), detects polymorphism
- UniSTS:516431

AU022717 (e-PCR)
- UniSTS:167529

D7Mit371 (e-PCR), detects polymorphism
- UniSTS:159706

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-phosphoadenosine 5'-phosphosulfate binding	ISO Inferred from Sequence Orthology more info
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in hexose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in hexose biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 15

Names: B-cell RAG-associated gene protein; GalNAc 4-sulfate 6-O-sulfotransferase; N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase; carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

NP_001347697.1

EC 2.8.2.33

NP_084211.2

EC 2.8.2.33

XP_006508395.1

EC 2.8.2.33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.