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    Hormad1 HORMA domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 67981, updated on 21-Apr-2024

    Summary

    Official Symbol
    Hormad1provided by MGI
    Official Full Name
    HORMA domain containing 1provided by MGI
    Primary source
    MGI:MGI:1915231
    See related
    Ensembl:ENSMUSG00000028109 AllianceGenome:MGI:1915231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nohma; 4921522K05Rik
    Summary
    Involved in several processes, including gamete generation; meiotic chromosome segregation; and regulation of cell cycle process. Acts upstream of or within homologous chromosome pairing at meiosis. Located in cytoplasm and synaptonemal complex. Is expressed in gonad. Orthologous to human HORMAD1 (HORMA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 6.9) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95466988..95495174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95559677..95587863)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7927 Neighboring gene predicted gene, 40096 Neighboring gene high mobility group box 1, pseudogene 5 Neighboring gene cathepsin S Neighboring gene STARR-positive B cell enhancer mm9_chr3:95392515-95392816 Neighboring gene predicted gene, 40097 Neighboring gene golgi phosphoprotein 3-like Neighboring gene ribosomal protein S10, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synaptonemal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    HORMA domain-containing protein 1
    Names
    HORMA domain containing protein
    newborn ovary HORMA protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289532.1NP_001276461.1  HORMA domain-containing protein 1 isoform a

      See identical proteins and their annotated locations for NP_001276461.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK014945, AK016743, AV259564, AW552644
      Consensus CDS
      CCDS71292.1
      UniProtKB/Swiss-Prot
      Q9CUF3, Q9D473, Q9D5T7
      Related
      ENSMUSP00000029754.7, ENSMUST00000029754.13
      Conserved Domains (1) summary
      pfam02301
      Location:27221
      HORMA; HORMA domain
    2. NM_001289534.1NP_001276463.1  HORMA domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_001276463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK016743, AV259564, AW552644, BC051129
      Consensus CDS
      CCDS38547.1
      UniProtKB/Swiss-Prot
      Q9D5T7
      Related
      ENSMUSP00000102772.2, ENSMUST00000107154.4
      Conserved Domains (1) summary
      pfam02301
      Location:24221
      HORMA; HORMA domain
    3. NM_001289537.1NP_001276466.1  HORMA domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_001276466.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK016743, AK163995, BC051129
      Consensus CDS
      CCDS38547.1
      UniProtKB/Swiss-Prot
      Q9D5T7
      Related
      ENSMUSP00000127180.2, ENSMUST00000171191.6
      Conserved Domains (1) summary
      pfam02301
      Location:24221
      HORMA; HORMA domain
    4. NM_001373886.1NP_001360815.1  HORMA domain-containing protein 1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC092203
      UniProtKB/Swiss-Prot
      Q9CUF3, Q9D473, Q9D5T7
      Conserved Domains (1) summary
      pfam02301
      Location:27221
      HORMA; HORMA domain
    5. NM_026489.3NP_080765.1  HORMA domain-containing protein 1 isoform b

      See identical proteins and their annotated locations for NP_080765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AK016743, AV259564, AW552644
      Consensus CDS
      CCDS38547.1
      UniProtKB/Swiss-Prot
      Q9D5T7
      Related
      ENSMUSP00000088303.5, ENSMUST00000090797.11
      Conserved Domains (1) summary
      pfam02301
      Location:24221
      HORMA; HORMA domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95466988..95495174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)