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    Elmo3 engulfment and cell motility 3 [ Mus musculus (house mouse) ]

    Gene ID: 234683, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Elmo3provided by MGI
    Official Full Name
    engulfment and cell motility 3provided by MGI
    Primary source
    MGI:MGI:2679007
    See related
    Ensembl:ENSMUSG00000014791 AllianceGenome:MGI:2679007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ced12; CED-12; 9930107J06
    Summary
    Predicted to enable SH3 domain binding activity. Predicted to be involved in actin filament organization and cell motility. Predicted to act upstream of or within apoptotic process and phagocytosis. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; nasal cavity epithelium; and skeleton. Orthologous to human ELMO3 (engulfment and cell motility 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in colon adult (RPKM 31.3), large intestine adult (RPKM 26.4) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 D3; 8 53.04 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106032240..106036625)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105305461..105310623)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102636360 Neighboring gene exocyst complex component 3-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain. Sato Y, et al. Gene Expr Patterns, 2019 Dec. PMID 31521773
    2. Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Tran V, et al. Nat Commun, 2022 Nov 18. PMID 36400788, Free PMC Article
    3. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0267, MGC67684

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    engulfment and cell motility protein 3
    Names
    engulfment and cell motility 3, ced-12 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172760.4 → NP_766348.3  engulfment and cell motility protein 3

      See identical proteins and their annotated locations for NP_766348.3

      Status: VALIDATED

      Source sequence(s)
      AC124584
      Consensus CDS
      CCDS22598.1
      UniProtKB/Swiss-Prot
      Q6PDE4, Q8BYZ7
      UniProtKB/TrEMBL
      Q05D34
      Related
      ENSMUSP00000105000.3, ENSMUST00000109375.4
      Conserved Domains (3) summary
      pfam04727
      Location:293 → 463
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 267
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:534 → 663
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106032240..106036625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243498.2 → XP_030099358.1  engulfment and cell motility protein 3 isoform X1

      Conserved Domains (3) summary
      pfam04727
      Location:319 → 490
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 266
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:561 → 690
      PH-like; Pleckstrin homology-like domain

    2. XM_030243500.2 → XP_030099360.1  engulfment and cell motility protein 3 isoform X4

      Conserved Domains (3) summary
      pfam04727
      Location:333 → 446
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:115 → 266
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:517 → 646
      PH-like; Pleckstrin homology-like domain

    3. XM_030243499.2 → XP_030099359.1  engulfment and cell motility protein 3 isoform X2

      Conserved Domains (3) summary
      pfam04727
      Location:302 → 473
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:98 → 249
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:544 → 673
      PH-like; Pleckstrin homology-like domain

    4. XM_006530890.5 → XP_006530953.1  engulfment and cell motility protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A1D5RMK9, Q05D34
      Related
      ENSMUSP00000148820.2, ENSMUST00000212033.2
      Conserved Domains (3) summary
      pfam04727
      Location:275 → 446
      ELMO_CED12; ELMO/CED-12 family
      pfam11841
      Location:98 → 250
      DUF3361; Domain of unknown function (DUF3361)
      cl17171
      Location:517 → 646
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BYZ7.2 GenPept UniProtKB/Swiss-Prot:Q8BYZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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