Id2 inhibitor of DNA binding 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Id2provided by MGI
Official Full Name: inhibitor of DNA binding 2provided by MGI
Primary source: MGI:MGI:96397
See related: Ensembl:ENSMUSG00000020644 AllianceGenome:MGI:96397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Idb2; bHLHb26
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and transcription regulator inhibitor activity. Involved in several processes, including animal organ development; entrainment of circadian clock by photoperiod; and regulation of gene expression. Acts upstream of with a negative effect on regulation of neural precursor cell proliferation and regulation of neuron differentiation. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and positive regulation of cell differentiation. Located in cytoplasm; euchromatin; and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; sensory organ; and urinary system. Orthologous to human ID2 (inhibitor of DNA binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 169.1), adrenal adult (RPKM 168.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.3; 12 8.57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (25143798..25146091, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (25093799..25096092, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.
Title: Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.
BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition.
Title: BMPR1A promotes ID2-ZEB1 interaction to suppress excessive endothelial to mesenchymal transition.
Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.
Title: Insulin Elevates ID2 Expression in Trophoblasts and Aggravates Preeclampsia in Obese ASB4-Null Mice.
ID2 controls differentiation of enteroendocrine cells in mouse small intestine.
Title: ID2 controls differentiation of enteroendocrine cells in mouse small intestine.
Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer.
Title: Inhibitor of DNA binding 2 knockdown inhibits the growth and liver metastasis of colorectal cancer.
Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
Title: Recurrent rewiring of the adult hippocampal mossy fiber system by a single transcriptional regulator, Id2.
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Title: DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfbeta-Id2 axis, for tissue regeneration.
Title: Airway basal stem cells reutilize the embryonic proliferation regulator, Tgfβ-Id2 axis, for tissue regeneration.
The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
Title: The transcriptional repressor ID2 supports natural killer cell maturation by controlling TCF1 amplitude.
Inhibitor of DNA binding 2 (Id2) Regulates Photic Entrainment Responses in Mice: Differential Responses of the Id2-/- Mouse Circadian System Are Dependent on Circadian Phase and on Duration and Intensity of Light.
Title: Inhibitor of DNA binding 2 (Id2) Regulates Photic Entrainment Responses in Mice: Differential Responses of the Id2-/- Mouse Circadian System Are Dependent on Circadian Phase and on Duration and Intensity of Light.

Submit: New GeneRIF Correction See all GeneRIFs (127)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (16) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94852 (e-PCR)
- UniSTS:120098

Id2 (e-PCR), detects polymorphism
- UniSTS:547641

Id2 (e-PCR), detects polymorphism
- UniSTS:528220

PMC140618P1 (e-PCR)
- UniSTS:270945

RH126462 (e-PCR)
- UniSTS:163170

PMC133998P2 (e-PCR)
- UniSTS:270707

AI255428 (e-PCR)
- UniSTS:180374

Idb2 (e-PCR), detects polymorphism
- UniSTS:256940

PMC305683P2 (e-PCR)
- UniSTS:272558

Idb2 (e-PCR), detects polymorphism
- UniSTS:256473

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription regulator inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Peyer's patch development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bundle of His development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lithium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular senescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryonic digestive tract morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in endodermal digestive tract morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within entrainment of circadian clock	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in entrainment of circadian clock by photoperiod	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within enucleate erythrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial cell differentiation involved in mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within leukocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymph node development	TAS Traceable Author Statement more info	PubMed
involved_in mammary gland alveolus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mammary gland epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in membranous septum morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within metanephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of core promoter binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of muscle cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within oligodendrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of gene expression	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of white fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of euchromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-2

Names: inhibitor of differentiation 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010496.3 → NP_034626.1 DNA-binding protein inhibitor ID-2

See identical proteins and their annotated locations for NP_034626.1

Status: VALIDATED

Source sequence(s)

AK135547, BQ044638

Consensus CDS

CCDS25846.1

UniProtKB/Swiss-Prot

O88604, P41136

UniProtKB/TrEMBL

Q545T4

Related

ENSMUSP00000020974.7, ENSMUST00000020974.7

Conserved Domains (1) summary

cd19692
Location:18 → 83

bHLH_dnHLH_ID2; basic helix-loop-helix (bHLH) domain found in DNA-binding protein inhibitor ID2 and similar proteins