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    Dctd dCMP deaminase [ Mus musculus (house mouse) ]

    Gene ID: 320685, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dctdprovided by MGI
    Official Full Name
    dCMP deaminaseprovided by MGI
    Primary source
    MGI:MGI:2444529
    See related
    Ensembl:ENSMUSG00000031562 AllianceGenome:MGI:2444529
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6030466N05Rik
    Summary
    Predicted to enable dCMP deaminase activity and identical protein binding activity. Predicted to be involved in dTMP biosynthetic process and dUMP biosynthetic process. Predicted to act upstream of or within nucleotide biosynthetic process. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and respiratory system. Orthologous to human DCTD (dCMP deaminase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in limb E14.5 (RPKM 14.2), CNS E11.5 (RPKM 7.8) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 B1.1- B1.2; 8 26.98 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (48552127..48594702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (48099092..48141667)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene WW, C2 and coiled-coil domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_21422 Neighboring gene STARR-seq mESC enhancer starr_21423 Neighboring gene predicted gene, 31984 Neighboring gene STARR-seq mESC enhancer starr_21426 Neighboring gene predicted gene, 32052 Neighboring gene STARR-seq mESC enhancer starr_21427 Neighboring gene STARR-seq mESC enhancer starr_21428 Neighboring gene STARR-seq mESC enhancer starr_21430 Neighboring gene predicted gene, 39174 Neighboring gene STARR-seq mESC enhancer starr_21431 Neighboring gene STARR-seq mESC enhancer starr_21432 Neighboring gene STARR-seq mESC enhancer starr_21434 Neighboring gene predicted gene, 32194 Neighboring gene predicted gene, 51559

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article
    2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dCMP deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytidine deamination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleoside salvage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    deoxycytidylate deaminase
    NP_001154987.2
    NP_001154988.2
    NP_848903.3
    XP_006509505.1
    XP_036009996.1
    XP_036009997.1
    XP_036009998.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161515.2 → NP_001154987.2  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8BP55, Q8K2D6
      Related
      ENSMUSP00000033966.8, ENSMUST00000033966.14
      Conserved Domains (1) summary
      cd01286
      Location:17 → 138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    2. NM_001161516.2 → NP_001154988.2  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8BP55, Q8K2D6
      Related
      ENSMUSP00000133445.3, ENSMUST00000174278.9
      Conserved Domains (1) summary
      cd01286
      Location:17 → 138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    3. NM_178788.5 → NP_848903.3  deoxycytidylate deaminase

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AC164420
      Consensus CDS
      CCDS22302.2
      UniProtKB/Swiss-Prot
      Q8BP55, Q8K2D6
      Related
      ENSMUSP00000126733.4, ENSMUST00000170263.10
      Conserved Domains (1) summary
      cd01286
      Location:17 → 138
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RNA

    1. NR_027759.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC164420, AI327164, AK077663, AV323917, BB193146, BB621273, BQ572929, BY014599
      Related
      ENSMUST00000174818.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      48552127..48594702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154105.1 → XP_036009998.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23 → 126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    2. XM_036154103.1 → XP_036009996.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23 → 126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    3. XM_036154104.1 → XP_036009997.1  deoxycytidylate deaminase isoform X1

      Conserved Domains (1) summary
      cd01286
      Location:23 → 126
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    4. XM_006509442.4 → XP_006509505.1  deoxycytidylate deaminase isoform X2

      See identical proteins and their annotated locations for XP_006509505.1

      UniProtKB/TrEMBL
      G3X908
      Conserved Domains (1) summary
      cd01286
      Location:23 → 144
      deoxycytidylate_deaminase; Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the ...

    RNA

    1. XR_003947308.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2D6.1 GenPept UniProtKB/Swiss-Prot:Q8K2D6

    Gene LinkOut

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