U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Synj1 synaptojanin 1 [ Mus musculus (house mouse) ]

    Gene ID: 104015, updated on 21-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Synj1provided by MGI
    Official Full Name
    synaptojanin 1provided by MGI
    Primary source
    MGI:MGI:1354961
    See related
    Ensembl:ENSMUSG00000022973 AllianceGenome:MGI:1354961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0910; A930006D20Rik
    Summary
    Enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in postsynaptic neurotransmitter receptor internalization; regulation of postsynaptic neurotransmitter receptor internalization; and synaptic vesicle uncoating. Acts upstream of or within several processes, including dephosphorylation; synaptic vesicle cycle; and synaptic vesicle transport. Located in Schaffer collateral - CA1 synapse and glutamatergic synapse. Part of membrane coat. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Parkinson's disease; Parkinson's disease 20; and developmental and epileptic encephalopathy 53. Orthologous to human SYNJ1 (synaptojanin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in frontal lobe adult (RPKM 17.6), cortex adult (RPKM 16.9) and 26 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16 C3.3; 16 52.18 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90732980..90810543, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90936092..91013727, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene eva-1 homolog C Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene cilia and flagella associate protien 298 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449 Neighboring gene STARR-seq mESC enhancer starr_41471 Neighboring gene PAX3 and PAX7 binding protein 1 Neighboring gene exosomal polycystin 1 interacting protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons. Zhu X, et al. eNeuro, 2023 May. PMID 37072173, Free PMC Article
    2. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes. Pan PY, et al. J Biol Chem, 2021 Jul. PMID 34126070, Free PMC Article
    3. Synaptojanin 1-mediated PI(4,5)P2 hydrolysis is modulated by membrane curvature and facilitates membrane fission. Chang-Ileto B, et al. Dev Cell, 2011 Feb 15. PMID 21316588, Free PMC Article
    4. Oligomeric amyloid-beta peptide disrupts phosphatidylinositol-4,5-bisphosphate metabolism. Berman DE, et al. Nat Neurosci, 2008 May. PMID 18391946, Free PMC Article
    5. Absence of Sac2/INPP5F enhances the phenotype of a Parkinson's disease mutation of synaptojanin 1. Cao M, et al. Proc Natl Acad Sci U S A, 2020 Jun 2. PMID 32424101, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
      Title: SYNJ1 rescues motor functions in hereditary and sporadic Parkinson's disease mice by upregulating TSP-1 expression.
    2. Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
      Title: Synaptojanin1 Modifies Endolysosomal Parameters in Cultured Ventral Midbrain Neurons.
    3. These data uncover a previously unidentified mechanism that links ApoE4-induced phospholipid changes to the pathogenic nature of ApoE4 in Alzheimer's disease.
      Title: Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis.
    4. Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
      Title: Synaptojanin1 deficiency upregulates basal autophagosome formation in astrocytes.
    5. Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
      Title: Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.
    6. SYNJ1 contributes to memory deficits in the aging hippocampus in all forms of Alzheimer's disease.
      Title: Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.
    7. report showing expression, location and isoforms of Synj1 and Synj2 in the small and large intestine and that they might participate in intestinal pathology.
      Title: The Synaptojanins in the murine small and large intestine.
    8. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses
      Title: Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons.
    9. a novel mechanism by which reduction of a PI(4,5)P2-degrading enzyme, synj1, improves amyloid-induced neuropathology and behavior deficits through accelerating cellular Abeta clearance.
      Title: Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.
    10. These results implicate Pak5 in Pacsin1- and Synaptojanin1-mediated synaptic vesicle trafficking.
      Title: Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables EH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol phosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol phosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neurotransmitter transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within phosphatidylinositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of endosome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gliogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic vesicle recycling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic vesicle endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle uncoating IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within synaptic vesicle uncoating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle uncoating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of clathrin coat TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of clathrin coat of coated pit ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of membrane coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    synaptojanin-1
    Names
    synaptic inositol 1,4,5-trisphosphate 5-phosphatase 1
    NP_001038980.1
    NP_001157955.1
    NP_001392321.1
    NP_001392322.1
    NP_001392323.1
    NP_001392324.1
    NP_001392325.1
    NP_001392326.1
    NP_001392328.1
    NP_001392329.1
    NP_001392330.1
    NP_001392331.1
    NP_001392332.1
    NP_001392333.1
    NP_001392334.1
    NP_001392335.1
    NP_001392336.1
    NP_001392337.1
    NP_001392339.1
    XP_006522900.1
    XP_006522909.1
    XP_011244377.1
    XP_011244378.1
    XP_011244379.1
    XP_011244380.1
    XP_011244381.1
    XP_011244382.1
    XP_011244383.1
    XP_011244384.1
    XP_011244385.1
    XP_011244386.1
    XP_011244387.1
    XP_011244389.1
    XP_011244391.1
    XP_017172325.1
    XP_017172326.1
    XP_017172328.1
    XP_017172329.1
    XP_017172330.1
    XP_030104762.1
    XP_030104763.1
    XP_030104765.1
    XP_030104766.1
    XP_030104768.1
    XP_030104769.1
    XP_030104770.1
    XP_036015603.1
    XP_036015605.1
    XP_036015606.1
    XP_036015610.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045515.2 → NP_001038980.1  synaptojanin-1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and includes an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The resulting isoform (b) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC134560, AC141885
      Consensus CDS
      CCDS49906.1
      UniProtKB/TrEMBL
      E9Q7S0, F7BQW7
      Related
      ENSMUSP00000128997.2, ENSMUST00000170853.8
      Conserved Domains (3) summary
      cd09098
      Location:533 → 868
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      pfam02383
      Location:60 → 340
      Syja_N; SacI homology domain
      cl17169
      Location:867 → 1008
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. NM_001164483.2 → NP_001157955.1  synaptojanin-1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC134560, AC141885
      Consensus CDS
      CCDS49907.1
      UniProtKB/Swiss-Prot
      Q8CHC4
      UniProtKB/TrEMBL
      D3Z656
      Related
      ENSMUSP00000113308.2, ENSMUST00000121759.8
      Conserved Domains (3) summary
      cd09098
      Location:573 → 908
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      pfam02383
      Location:100 → 380
      Syja_N; SacI homology domain
      cl17169
      Location:907 → 1048
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001405392.1 → NP_001392321.1  synaptojanin-1 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    4. NM_001405393.1 → NP_001392322.1  synaptojanin-1 isoform d

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    5. NM_001405394.1 → NP_001392323.1  synaptojanin-1 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    6. NM_001405395.1 → NP_001392324.1  synaptojanin-1 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885
      Related
      ENSMUSP00000113518.3, ENSMUST00000118390.10

    7. NM_001405396.1 → NP_001392325.1  synaptojanin-1 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    8. NM_001405397.1 → NP_001392326.1  synaptojanin-1 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    9. NM_001405399.1 → NP_001392328.1  synaptojanin-1 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    10. NM_001405400.1 → NP_001392329.1  synaptojanin-1 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    11. NM_001405401.1 → NP_001392330.1  synaptojanin-1 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    12. NM_001405402.1 → NP_001392331.1  synaptojanin-1 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    13. NM_001405403.1 → NP_001392332.1  synaptojanin-1 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    14. NM_001405404.1 → NP_001392333.1  synaptojanin-1 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    15. NM_001405405.1 → NP_001392334.1  synaptojanin-1 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    16. NM_001405406.1 → NP_001392335.1  synaptojanin-1 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    17. NM_001405407.1 → NP_001392336.1  synaptojanin-1 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    18. NM_001405408.1 → NP_001392337.1  synaptojanin-1 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    19. NM_001405410.1 → NP_001392339.1  synaptojanin-1 isoform s

      Status: VALIDATED

      Source sequence(s)
      AC134560, AC141885

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90732980..90810543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248902.2 → XP_030104762.1  synaptojanin-1 isoform X3

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:669 → 1004
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1196 → 1598
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1003 → 1144
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036159712.1 → XP_036015605.1  synaptojanin-1 isoform X14

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:677 → 1012
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1154 → 1544
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1011 → 1152
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. XM_017316840.3 → XP_017172329.1  synaptojanin-1 isoform X37

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:677 → 1012
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1154 → 1378
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1011 → 1152
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_030248903.2 → XP_030104763.1  synaptojanin-1 isoform X9

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:677 → 1012
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1154 → 1557
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1011 → 1152
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. XM_017316836.3 → XP_017172325.1  synaptojanin-1 isoform X10

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:677 → 1012
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1204 → 1577
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1011 → 1152
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. XM_006522837.5 → XP_006522900.1  synaptojanin-1 isoform X6

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:677 → 1012
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 624
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1154 → 1570
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1011 → 1152
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. XM_011246082.4 → XP_011244384.1  synaptojanin-1 isoform X15

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:672 → 1007
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1149 → 1539
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1006 → 1147
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. XM_017316841.3 → XP_017172330.1  synaptojanin-1 isoform X38

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:672 → 1007
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1149 → 1373
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1006 → 1147
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. XM_036159710.1 → XP_036015603.1  synaptojanin-1 isoform X11

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:672 → 1007
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1172 → 1552
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1006 → 1147
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_011246076.4 → XP_011244378.1  synaptojanin-1 isoform X2

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:672 → 1007
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1199 → 1601
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1006 → 1147
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_011246081.4 → XP_011244383.1  synaptojanin-1 isoform X13

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1547
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    12. XM_030248910.2 → XP_030104770.1  synaptojanin-1 isoform X36

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1381
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    13. XM_017316839.3 → XP_017172328.1  synaptojanin-1 isoform X35

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1381
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. XM_011246079.4 → XP_011244381.1  synaptojanin-1 isoform X7

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1560
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    15. XM_030248908.2 → XP_030104768.1  synaptojanin-1 isoform X31

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      PRK07764
      Location:1200 → 1394
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    16. XM_011246077.4 → XP_011244379.1  synaptojanin-1 isoform X4

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1576
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    17. XM_011246080.4 → XP_011244382.1  synaptojanin-1 isoform X8

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1207 → 1580
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    18. XM_036159717.1 → XP_036015610.1  synaptojanin-1 isoform X33

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1201 → 1424
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. XM_030248909.2 → XP_030104769.1  synaptojanin-1 isoform X32

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1201 → 1397
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    20. XM_011246078.4 → XP_011244380.1  synaptojanin-1 isoform X5

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1157 → 1573
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    21. XM_011246075.4 → XP_011244377.1  synaptojanin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1207 → 1609
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    22. XM_011246085.4 → XP_011244387.1  synaptojanin-1 isoform X24

      See identical proteins and their annotated locations for XP_011244387.1

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03378
      Location:1119 → 1423
      PHA03378; EBNA-3B; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    23. XM_017316837.3 → XP_017172326.1  synaptojanin-1 isoform X23

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03378
      Location:1119 → 1423
      PHA03378; EBNA-3B; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    24. XM_030248905.2 → XP_030104765.1  synaptojanin-1 isoform X18

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:533 → 868
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1060 → 1462
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:60 → 480
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:867 → 1008
      RRM_SF; RNA recognition motif (RRM) superfamily

    25. XM_030248906.1 → XP_030104766.1  synaptojanin-1 isoform X20

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:525 → 860
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1052 → 1454
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:60 → 480
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:859 → 1000
      RRM_SF; RNA recognition motif (RRM) superfamily

    26. XM_036159713.1 → XP_036015606.1  synaptojanin-1 isoform X21

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:528 → 863
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      COG5329
      Location:60 → 483
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      pfam03154
      Location:1005 → 1395
      Atrophin-1; Atrophin-1 family
      cl17169
      Location:862 → 1003
      RRM_SF; RNA recognition motif (RRM) superfamily

    27. XM_011246084.1 → XP_011244386.1  synaptojanin-1 isoform X19

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:528 → 863
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1055 → 1457
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:60 → 483
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:862 → 1003
      RRM_SF; RNA recognition motif (RRM) superfamily

    28. XM_011246083.1 → XP_011244385.1  synaptojanin-1 isoform X17

      UniProtKB/Swiss-Prot
      Q8CHC4
      Conserved Domains (4) summary
      cd09098
      Location:536 → 871
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:1063 → 1465
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:60 → 483
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:870 → 1011
      RRM_SF; RNA recognition motif (RRM) superfamily

    29. XM_011246089.4 → XP_011244391.1  synaptojanin-1 isoform X43

      Conserved Domains (4) summary
      cd09098
      Location:86 → 421
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:607 → 1015
      PHA03247; large tegument protein UL36; Provisional
      COG5329
      Location:2 → 33
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:420 → 561
      RRM_SF; RNA recognition motif (RRM) superfamily

    30. XM_006522846.4 → XP_006522909.1  synaptojanin-1 isoform X44

      Conserved Domains (3) summary
      cd09098
      Location:14 → 349
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03247
      Location:535 → 943
      PHA03247; large tegument protein UL36; Provisional
      cl17169
      Location:348 → 489
      RRM_SF; RNA recognition motif (RRM) superfamily

    31. XM_011246087.4 → XP_011244389.1  synaptojanin-1 isoform X25

      UniProtKB/TrEMBL
      F7BQW7
      Conserved Domains (4) summary
      cd09098
      Location:680 → 1015
      INPP5c_Synj1; Catalytic inositol polyphosphate 5-phosphatase (INPP5c) domain of synaptojanin 1
      PHA03378
      Location:1119 → 1423
      PHA03378; EBNA-3B; Provisional
      COG5329
      Location:204 → 627
      COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
      cl17169
      Location:1014 → 1155
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_876128.4 RNA Sequence

    2. XR_004939141.1 RNA Sequence

    3. XR_004939140.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHC4.3 GenPept UniProtKB/Swiss-Prot:Q8CHC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous