Morf4l1 mortality factor 4 like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Morf4l1provided by MGI
Official Full Name: mortality factor 4 like 1provided by MGI
Primary source: MGI:MGI:1096551
See related: Ensembl:ENSMUSG00000062270 AllianceGenome:MGI:1096551
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MRG15; Tex189; TEG-189; MORFRG15; mKIAA4002
Summary: Enables chromatin binding activity. Acts upstream of or within cell population proliferation. Predicted to be located in nuclear speck. Predicted to be part of NuA4 histone acetyltransferase complex and Sin3 complex. Is expressed in several structures, including genitourinary system; limb; liver; retina; and spleen. Orthologous to human MORF4L1 (mortality factor 4 like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 222.1), CNS E11.5 (RPKM 158.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.1; 9 47.42 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (89973722..89996873, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (90091669..90114820, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM.
Title: MRG15 aggravates non-alcoholic steatohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM.
MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism.
Title: MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism.
In round spermatids, MRG15 colocalizes with splicing factors PTBP1 and PTBP2 at H3K36me3 sites between the exons and single intron of transition nuclear protein 2 (Tnp2). Thus, our results reveal that MRG15 is essential for pre-mRNA splicing during spermatogenesis and that epigenetic regulation of pre-mRNA splicing by histone modification could be useful to understand not only spermatogenesis but also, epigenetic disorder
Title: MRG15 is required for pre-mRNA splicing and spermatogenesis.
HDAC2-dependent deacetylation of MORF4L1 enhances MORF4L1 homodimerization, thus facilitating the functionality of complex formation to repress cell proliferation.
Title: Histone deacetylase 2 (HDAC2) protein-dependent deacetylation of mortality factor 4-like 1 (MORF4L1) protein enhances its homodimerization.
DNA damage foci, as indicated by immunostaining for gammaH2AX and 53BP1, are detectable in a sub-population of Mrg15 deficient NSC cultures under normal growing conditions and the majority of p21-positive cells are also positive for 53BP1 foci.
Title: Loss of the chromatin regulator MRG15 limits neural stem/progenitor cell proliferation via increased expression of the p21 Cdk inhibitor.
Our results demonstrate that MRG15 has more than one function in neurogenesis and defines a novel role for this chromatin regulator that integrates proliferation and cell-fate determination in neurogenesis during development.
Title: MRG15, a component of HAT and HDAC complexes, is essential for proliferation and differentiation of neural precursor cells.
Formation of phosphorylated H2AX and 53BP1 foci was delayed in Mrg15 mutant versus wild-type cells following irradiation. These data implicate a novel role for MRG15 in DNA-damage repair in mammalian cells.
Title: Mrg15 null and heterozygous mouse embryonic fibroblasts exhibit DNA-repair defects post exposure to gamma ionizing radiation.
MRG15 has an essential role in embryonic development via chromatin remodeling and transcriptional regulation.
Title: MRG15 regulates embryonic development and cell proliferation.
MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review]
Title: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Clone Names

KIAA4002, MGC102415, MGC103105, MGC118047

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of NuA4 histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NuA4 histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of Sin3-type complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: mortality factor 4-like protein 1

Names: MORF-related gene 15 protein; testis expressed gene 189; testis-expressed gene 189 protein; transcription factor-like protein MRG15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039147.2 → NP_001034236.1 mortality factor 4-like protein 1 isoform a

See identical proteins and their annotated locations for NP_001034236.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC140392, BC085103

Consensus CDS

CCDS23400.1

UniProtKB/Swiss-Prot

P60762, Q8BNY9, Q99MQ0

UniProtKB/TrEMBL

Q3UIS6

Related

ENSMUSP00000082346.6, ENSMUST00000085248.12

Conserved Domains (2) summary

cd18983
Location:15 → 110

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:184 → 351

MRG
NM_001357780.1 → NP_001344709.1 mortality factor 4-like protein 1 isoform c

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC140392

UniProtKB/TrEMBL

Q3UIS6

Conserved Domains (2) summary

cd18983
Location:15 → 109

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:183 → 350

MRG
NM_024431.3 → NP_077751.1 mortality factor 4-like protein 1 isoform b

See identical proteins and their annotated locations for NP_077751.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC140392, AK167079, BC085103

Consensus CDS

CCDS52885.1

UniProtKB/TrEMBL

Q3UIS6, Q569V4

Related

ENSMUSP00000132020.2, ENSMUST00000169860.8

Conserved Domains (2) summary

cd18983
Location:15 → 71

CBD_MSL3_like; chromo barrel domain of human male-specific lethal complex subunit 3, and similar proteins

pfam05712
Location:145 → 312

MRG