Psmd11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psmd11provided by MGI
Official Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11provided by MGI
Primary source: MGI:MGI:1916327
See related: Ensembl:ENSMUSG00000017428 AllianceGenome:MGI:1916327
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: S9; P44.5; 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik
Summary: Predicted to enable structural molecule activity. Predicted to be involved in proteasome assembly; stem cell differentiation; and ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in central nervous system; heart; neural retina; and skeletal muscle. Orthologous to human PSMD11 (proteasome 26S subunit, non-ATPase 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 25.8), liver E14 (RPKM 25.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 47.89 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (80319441..80364074)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (80428615..80473248)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.
Title: Generation and identification of a conditional knockout allele for the PSMD11 gene in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

H05L03.2 (e-PCR)
- UniSTS:311318

BE197379 (e-PCR)
- UniSTS:207401

NoName (e-PCR)
- UniSTS:492342

AW527866 (e-PCR)
- UniSTS:246086

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:236661

D11Bhm121 (e-PCR), detects polymorphism
- UniSTS:141558

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural molecule activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in proteasome assembly	ISO Inferred from Sequence Orthology more info
involved_in stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of proteasome accessory complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome accessory complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome regulatory particle	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 26S proteasome non-ATPase regulatory subunit 11

Names: 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; 26S proteasome regulatory subunit p44.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178616.3 → NP_848731.2 26S proteasome non-ATPase regulatory subunit 11

See identical proteins and their annotated locations for NP_848731.2

Status: VALIDATED

Source sequence(s)

AK136049, BC119138, BY092952

Consensus CDS

CCDS25133.1

UniProtKB/Swiss-Prot

Q8BG32

UniProtKB/TrEMBL

Q3THG2, Q3UWW9, Q5BKQ9

Related

ENSMUSP00000017572.8, ENSMUST00000017572.14

Conserved Domains (1) summary

COG5159
Location:17 → 421

RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

80319441..80364074

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011249223.4 → XP_011247525.1 26S proteasome non-ATPase regulatory subunit 11 isoform X1

UniProtKB/TrEMBL

Q8K2N7

Conserved Domains (1) summary

COG5159
Location:28 → 343

RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]