Cd300lb CD300 molecule like family member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd300lbprovided by MGI
Official Full Name: CD300 molecule like family member Bprovided by MGI
Primary source: MGI:MGI:2685099
See related: Ensembl:ENSMUSG00000063193 AllianceGenome:MGI:2685099
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clm7; CLM-7; Gm253; LMIR5
Summary: Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Acts upstream of or within cellular response to lipopolysaccharide; neutrophil mediated immunity; and positive regulation of mast cell activation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Orthologous to human CD300LB (CD300 molecule like family member b). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 1.9), spleen adult (RPKM 1.9) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 80.55 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (114813605..114825197, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (114922779..114934371, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C. jejuni interacted preferentially with LMIR5.
Title: Campylobacter jejuni targets immunoglobulin-like receptor LMIR5.
LMIR5 extracellular domain is new inflammatory mediator and endogenous ligand of TLR4.
Title: LMIR5 extracellular domain activates myeloid cells through toll-like receptor 4.
neutrophil-derived soluble LMIR5 amplifies lipopolysaccharide-induced lethal inflammation.
Title: A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis.
TIM1 is an endogenous ligand for LMIR5.
Title: TIM1 is an endogenous ligand for LMIR5/CD300b: LMIR5 deficiency ameliorates mouse kidney ischemia/reperfusion injury.
although both mouse and human LMIR5 play activatory roles in innate immunity cells, the functions of LMIR5 were differentially regulated in mouse versus human cells.
Title: Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neutrophil mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of mast cell activation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CMRF35-like molecule 7

Names: CD300 antigen like family member B; CMRF-35-like molecule-7; IREM-3; immune receptor expressed on myeloid cells 3; leukocyte mono-Ig-like receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347651.2 → NP_001334580.1 CMRF35-like molecule 7 isoform 2

Status: VALIDATED

Source sequence(s)

AL607025, AL669969

Consensus CDS

CCDS83924.1

UniProtKB/TrEMBL

Q3B7Y7, Q3TEQ8

Related

ENSMUSP00000144728.2, ENSMUST00000149663.4
NM_199221.3 → NP_954691.3 CMRF35-like molecule 7 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AL607025, AL669969

Consensus CDS

CCDS25614.2

UniProtKB/Swiss-Prot

Q1ED86, Q3TCP3, Q3U497, Q6SJQ1

UniProtKB/TrEMBL

A0A0R3P9D2

Related

ENSMUSP00000159146.2, ENSMUST00000239005.2

Conserved Domains (1) summary

cd05716
Location:23 → 121

Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

114813605..114825197 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001037138.1: Suppressed sequence

Description

NM_001037138.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate. Support for the transcript exists but not for the protein.