Grm7 glutamate receptor, metabotropic 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grm7provided by MGI
Official Full Name: glutamate receptor, metabotropic 7provided by MGI
Primary source: MGI:MGI:1351344
See related: Ensembl:ENSMUSG00000056755 AllianceGenome:MGI:1351344
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SMN2; Gpr1g; Gprc1g; mGluR7; C030018L03; 6330570A01Rik; E130018M02Rik; Tg(SMN2)89Ahmb
Summary: Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in chemical synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 6.5), frontal lobe adult (RPKM 4.9) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 E3; 6 51.19 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (110622304..111544191)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (110645349..111567230)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
Title: PRMT inhibitor promotes SMN2 exon 7 inclusion and synergizes with nusinersen to rescue SMA mice.
A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
Title: A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
Title: A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes.
Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.
Title: Phenotypic profiling of mGlu(7) knockout mice reveals new implications for neurodevelopmental disorders.
Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
Title: Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.
Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
Title: Metabotropic glutamate receptor subtype 7 controls maternal care, maternal motivation and maternal aggression in mice.
A transsynaptic interaction between Elfn1 and mGluR7 constitutively reduces initial release probability onto mouse cortical SOM neurons. Elfn1 produces glutamate-independent activation of mGluR7 via presynaptic clustering, resulting in a divergence from the canonical "autoreceptor" role of Type III mGluRs, and substantially altering synaptic pharmacology.
Title: Elfn1-Induced Constitutive Activation of mGluR7 Determines Frequency-Dependent Recruitment of Somatostatin Interneurons.
mGlu7 is not functionally increased in mice overexpressing MeCP2 and that neither genetic nor pharmacological reduction of mGlu7 activity impacts phenotypes in a mouse model of MeCP2 duplication syndrome.
Title: Genetic Reduction or Negative Modulation of mGlu(7) Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome.
We found a significant reduction of testosterone levels in mGluR7 knockout (KO) mice. Social investigating behaviour of intact mGluR7 KO mice also differed from that of wild-type mice; e.g. the KO mice showing less frequent anogenital sniffing and more frequent grooming behaviour. Further, castrated mGluR7 KO mice have smaller seminal vesicles than those of castrated wild-type mice, although intact mice were no different.
Title: Metabotropic glutamate receptor subtype 7 has critical roles in regulation of the endocrine system and social behaviours.
Altered mGlu7 expression was found in brain regions associated with fear extinction in two different mouse strains which differ in their fear extinction behavior.
Title: Increased amygdalar metabotropic glutamate receptor 7 mRNA in a genetic mouse model of impaired fear extinction.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transgenic (1) 1 citation
Targeted (3) 1 citation
Chemically induced (ENU) (1)
Not Applicable (2) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

42.MHAa96d6.seq (e-PCR)
- UniSTS:124450

GRM7_1388 (e-PCR)
- UniSTS:277300

BB176677 (e-PCR)
- UniSTS:185677

D6Mit104 (e-PCR), detects polymorphism
- UniSTS:130648

D6Mit108 (e-PCR), detects polymorphism
- UniSTS:130651

px-35d4 (e-PCR)
- UniSTS:257635

UniSTS:495977 (e-PCR)
- UniSTS:495977

Avpr1b (e-PCR), detects polymorphism
- UniSTS:495977

D6Mit148 (e-PCR), detects polymorphism
- UniSTS:130693

RH44758 (e-PCR)
- UniSTS:29417

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	TAS Traceable Author Statement more info	PubMed
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables adenylate cyclase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables glutamate binding	ISO Inferred from Sequence Orthology more info
enables glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables group III metabotropic glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables group III metabotropic glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables serine binding	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled glutamate receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within associative learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within behavioral fear response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within conditioned taste aversion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glycosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organismal response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glutamate secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in presynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in asymmetric synapse	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic active zone membrane	TAS Traceable Author Statement more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metabotropic glutamate receptor 7

Names: G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; mGlu7a receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346640.1 → NP_001333569.1 metabotropic glutamate receptor 7 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC114643, AC125046, AC132394, AC142264, AC169981, AC169984

Consensus CDS

CCDS85110.1

UniProtKB/TrEMBL

G5E8D5

Related

ENSMUSP00000064404.7, ENSMUST00000071076.13

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR
NM_177328.3 → NP_796302.2 metabotropic glutamate receptor 7 isoform 1 precursor

See identical proteins and their annotated locations for NP_796302.2

Status: VALIDATED

Source sequence(s)

AC114643, AC125046, AC132394, AC142264, AC169981, AC169984

Consensus CDS

CCDS39587.1

UniProtKB/Swiss-Prot

Q68ED2

Related

ENSMUSP00000133957.2, ENSMUST00000172951.2

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

110622304..111544191

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505296.3 → XP_006505359.1 metabotropic glutamate receptor 7 isoform X1

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_017321298.3 → XP_017176787.1 metabotropic glutamate receptor 7 isoform X1

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_006505298.4 → XP_006505361.1 metabotropic glutamate receptor 7 isoform X2

See identical proteins and their annotated locations for XP_006505361.1

UniProtKB/TrEMBL

G5E8D5

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR
XM_006505301.3 → XP_006505364.1 metabotropic glutamate receptor 7 isoform X4

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_006505300.4 → XP_006505363.1 metabotropic glutamate receptor 7 isoform X3

Conserved Domains (3) summary

cd15451
Location:589 → 895

7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
XM_006505302.4 → XP_006505365.1 metabotropic glutamate receptor 7 isoform X5

Conserved Domains (3) summary

cd15286
Location:589 → 817

7tmC_mGluR_group3; metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors

pfam07562
Location:519 → 569

NCD3G; Nine Cysteines Domain of family 3 GPCR

cd06376
Location:43 → 511

PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor

RNA

XR_003956139.2 RNA Sequence
XR_003956140.2 RNA Sequence
XR_003956142.2 RNA Sequence
XR_003956141.2 RNA Sequence
XR_004942887.1 RNA Sequence
XR_001785078.3 RNA Sequence
XR_001785080.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_177970.1: Suppressed sequence

Description

NM_177970.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.