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    Gpm6a glycoprotein m6a [ Mus musculus (house mouse) ]

    Gene ID: 234267, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Gpm6aprovided by MGI
    Official Full Name
    glycoprotein m6aprovided by MGI
    Primary source
    MGI:MGI:107671
    See related
    Ensembl:ENSMUSG00000031517 AllianceGenome:MGI:107671
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    M6A; Gpm6
    Summary
    Predicted to enable calcium channel activity. Involved in neural retina development and neuron projection morphogenesis. Acts upstream of or within response to bacterium. Located in axonal growth cone. Is expressed in central nervous system; early nephron; intraembryonic coelom; sensory organ; and upper lip. Orthologous to human GPM6A (glycoprotein M6A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cortex adult (RPKM 193.1), frontal lobe adult (RPKM 175.9) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpm6a in Genome Data Viewer
    Location:
    8 B1.3; 8 29.33 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (55232469..55513913)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (54779434..55060878)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21499 Neighboring gene spermatogenesis associated 4 Neighboring gene STARR-seq mESC enhancer starr_21500 Neighboring gene WD repeat domain 17 Neighboring gene STARR-seq mESC enhancer starr_21502 Neighboring gene predicted gene, 53418 Neighboring gene STARR-seq mESC enhancer starr_21503 Neighboring gene predicted gene, 57523 Neighboring gene STARR-seq mESC enhancer starr_21505 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56197740-56198041 Neighboring gene STARR-positive B cell enhancer mm9_chr8:56199056-56199356 Neighboring gene a disintegrin and metallopeptidase domain 39 pseudogene Neighboring gene predicted gene, 53425

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a. Sato Y, et al. PLoS One, 2011. PMID 22162747, Free PMC Article
    2. SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION. Xie W, et al. Shock, 2023 May 1. PMID 36877222
    3. Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice. Xue A, et al. Mol Neurobiol, 2021 Aug. PMID 33826069
    4. Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules. Honda A, et al. J Neurosci, 2017 Apr 12. PMID 28275160, Free PMC Article
    5. Isolation and mapping of the human glycoprotein M6 gene (GPM6A) to 4q33-->q34. Shimizu F, et al. Cytogenet Cell Genet, 1996. PMID 8893821

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
      Title: Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice.
    2. Mettl14-mediated m[6]A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
      Title: Mettl14-mediated m(6)A modification ensures the cell-cycle progression of late-born retinal progenitor cells.
    3. SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION.
      Title: SILENCING M 6 A READER YTHDC1 REDUCES INFLAMMATORY RESPONSE IN SEPSIS-INDUCED CARDIOMYOPATHY BY INHIBITING SERPINA3N EXPRESSION.
    4. Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
      Title: Comprehensive Analysis of Differential m6A RNA Methylomes in the Hippocampus of Cocaine-Conditioned Mice.
    5. GPM6a induces the clustering of lipid rafts and acts as a signal transducer that responds to extracellular signals.
      Title: Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules.
    6. This study demonistrated that M6a is essential for the support of neurite extension in developmental brain.
      Title: Transcallosal Projections Require Glycoprotein M6-Dependent Neurite Growth and Guidance.
    7. analysis of actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a
      Title: Actin-independent behavior and membrane deformation exhibited by the four-transmembrane protein M6a.
    8. M6a-deficient axons grow actively but are not growth suppressed by antibodies bound to four-transmembrane actin-based glycoprotein M6a concentrated on the edge of the axon growth cone.
      Title: Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a.
    9. These results suggest that M6a plays a role in retinal development by regulating neurites, and it may also function to modulate synaptic activities in the adult retina.
      Title: M6a is expressed in the murine neural retina and regulates neurite extension.
    10. expression of shRNA against GPM6A markedly reduced the expression of neuroectodermal-associated genes (OTX1, Lmx1b, En1, Pax2, Pax5, Sox1, Sox2, and Wnt1), and also the number of neural stem cells (NSC) derived from D3mshM6A cells
      Title: Inhibition of mouse GPM6A expression leads to decreased differentiation of neurons derived from mouse embryonic stem cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38999

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural retina development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection morphogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synapse organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonal growth cone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in filopodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in parallel fiber to Purkinje cell synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic active zone membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    neuronal membrane glycoprotein M6-a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253754.1 → NP_001240683.1  neuronal membrane glycoprotein M6-a isoform 2

      See identical proteins and their annotated locations for NP_001240683.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different segment for its 5' end which results in the use of an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC109200, BC033357, CK623810, CX564488
      UniProtKB/TrEMBL
      Q8R1P3
      Conserved Domains (1) summary
      pfam01275
      Location:3 → 236
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    2. NM_001253756.1 → NP_001240685.1  neuronal membrane glycoprotein M6-a isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different segment in its 5' UTR and lacks an alternate exon in the 5' coding region, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AK081877, BC033357, BY247392, CD354193
      UniProtKB/Swiss-Prot
      P35802
      UniProtKB/TrEMBL
      Q542P2
      Conserved Domains (1) summary
      cl02417
      Location:1 → 148
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    3. NM_153581.6 → NP_705809.1  neuronal membrane glycoprotein M6-a isoform 1

      See identical proteins and their annotated locations for NP_705809.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK081877, BC033357, BY247392
      Consensus CDS
      CCDS22310.1
      UniProtKB/Swiss-Prot
      P35802
      UniProtKB/TrEMBL
      Q542P2
      Related
      ENSMUSP00000033915.8, ENSMUST00000033915.9
      Conserved Domains (1) summary
      pfam01275
      Location:14 → 247
      Myelin_PLP; Myelin proteolipid protein (PLP or lipophilin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      55232469..55513913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35802.1 GenPept UniProtKB/Swiss-Prot:P35802

    Gene LinkOut

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