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    Nlrp4b NLR family, pyrin domain containing 4B [ Mus musculus (house mouse) ]

    Gene ID: 210045, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Nlrp4bprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Bprovided by MGI
    Primary source
    MGI:MGI:3056570
    See related
    Ensembl:ENSMUSG00000034087 AllianceGenome:MGI:3056570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nalp4b; E330024M09; Nalp-gamma
    Summary
    Predicted to enable ATP binding activity. Predicted to act upstream of or within inflammatory response. Is expressed in ovary. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    Location:
    7 A1; 7 6.58 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (10421720..10464095)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (10687793..10730168)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene vomeronasal 1 receptor, pseudogene 52 Neighboring gene predicted gene 5130 Neighboring gene vomeronasal 1 receptor 71

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
    2. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
    3. Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. Joshi S, et al. BMC Dev Biol, 2007 Jun 13. PMID 17567914, Free PMC Article
    4. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 4B
    Names
    NACHT, leucine rich repeat and PYD containing 4B
    NACHT/LRR/pyrin domain-containing protein 4b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355151.1 → NP_001342080.1  NACHT, LRR and PYD domains-containing protein 4B

      Status: VALIDATED

      Source sequence(s)
      AC151720
      Consensus CDS
      CCDS20795.1
      UniProtKB/Swiss-Prot
      Q66X16, Q8C6J9
      UniProtKB/TrEMBL
      Q6NY05
      Related
      ENSMUSP00000113095.2, ENSMUST00000117413.9
      Conserved Domains (4) summary
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:715 → 742
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:145 → 311
      NACHT; NACHT domain
      cl26161
      Location:601 → 834
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    2. NM_172481.2 → NP_766069.1  NACHT, LRR and PYD domains-containing protein 4B

      See identical proteins and their annotated locations for NP_766069.1

      Status: VALIDATED

      Source sequence(s)
      AK054426
      Consensus CDS
      CCDS20795.1
      UniProtKB/Swiss-Prot
      Q66X16, Q8C6J9
      UniProtKB/TrEMBL
      Q6NY05
      Related
      ENSMUSP00000043881.5, ENSMUST00000047809.11
      Conserved Domains (4) summary
      cd08320
      Location:10 → 93
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:715 → 742
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:145 → 311
      NACHT; NACHT domain
      cl26161
      Location:601 → 834
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      10421720..10464095
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C6J9.1 GenPept UniProtKB/Swiss-Prot:Q8C6J9

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