Esco1 establishment of sister chromatid cohesion N-acetyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esco1provided by MGI
Official Full Name: establishment of sister chromatid cohesion N-acetyltransferase 1provided by MGI
Primary source: MGI:MGI:1925055
See related: Ensembl:ENSMUSG00000024293 AllianceGenome:MGI:1925055
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A930014I12Rik
Summary: Predicted to enable identical protein binding activity; peptide-lysine-N-acetyltransferase activity; and zinc ion binding activity. Predicted to be involved in protein acetylation; regulation of DNA replication; and sister chromatid cohesion. Predicted to be located in chromatin. Is expressed in gonad; reproductive system; and urinary system. Orthologous to human ESCO1 (establishment of sister chromatid cohesion N-acetyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 3.4), bladder adult (RPKM 2.6) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 5.21 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (10566507..10610863, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (10566507..10610863, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Alternative catalytic residues in the active site of Esco acetyltransferases.
Title: Alternative catalytic residues in the active site of Esco acetyltransferases.
Esco1 is required for alpha-tubulin acetylation and microtubule stability, which thereby ensures normal spindle assembly and proper chromosome alignment to orchestrate the mouse oocyte meiotic progression.
Title: The cohesion establishment factor Esco1 acetylates α-tubulin to ensure proper spindle assembly in oocyte meiosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237739 (e-PCR)
- UniSTS:237739

Esco1 (e-PCR), detects polymorphism
- UniSTS:546762

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peptide-lysine-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-lysine-N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-lysine acetylation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA replication	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in chromosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: N-acetyltransferase ESCO1

Names: ECO1 homolog 1; establishment of cohesion 1 homolog 1; establisment of cohesion 1 homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081222.1 → NP_001074691.1 N-acetyltransferase ESCO1

See identical proteins and their annotated locations for NP_001074691.1

Status: PROVISIONAL

Source sequence(s)

AC102441, AC105947

Consensus CDS

CCDS37737.1

UniProtKB/Swiss-Prot

B9EKQ9, Q69Z69, Q8BQI2, Q8BR47, Q922F5

UniProtKB/TrEMBL

Q3ULS5

Related

ENSMUSP00000025142.6, ENSMUST00000025142.13

Conserved Domains (2) summary

pfam13878
Location:607 → 646

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

pfam13880
Location:766 → 828

Acetyltransf_13; ESCO1/2 acetyl-transferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

10566507..10610863 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526353.4 → XP_006526416.1 N-acetyltransferase ESCO1 isoform X1

See identical proteins and their annotated locations for XP_006526416.1

UniProtKB/TrEMBL

Q3UKT9

Related

ENSMUSP00000095274.4, ENSMUST00000097670.10

Conserved Domains (2) summary

pfam13878
Location:108 → 147

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

pfam13880
Location:267 → 335

Acetyltransf_13; ESCO1/2 acetyl-transferase
XM_036161309.1 → XP_036017202.1 N-acetyltransferase ESCO1 isoform X2

Related

ENSMUSP00000111530.2, ENSMUST00000115864.8

Conserved Domains (2) summary

pfam13878
Location:83 → 122

zf-C2H2_3; zinc-finger of acetyl-transferase ESCO

pfam13880
Location:242 → 310

Acetyltransf_13; ESCO1/2 acetyl-transferase

RNA

XR_003952544.1 RNA Sequence

Related

ENSMUST00000127099.9
XR_001782403.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144542.1: Suppressed sequence

Description

NM_144542.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.