Ect2 ect2 oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ect2provided by MGI
Official Full Name: ect2 oncogeneprovided by MGI
Primary source: MGI:MGI:95281
See related: Ensembl:ENSMUSG00000027699 AllianceGenome:MGI:95281
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables small GTPase binding activity. Involved in positive regulation of neuron differentiation and positive regulation of protein import into nucleus. Acts upstream of or within cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in brain ventricular layer; liver; and rest of cerebellum marginal layer. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E11.5 (RPKM 13.0), liver E14 (RPKM 11.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 10.82 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (27151371..27207971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (27097222..27154253, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the oncogene ECT2 contributes to epithelial cell reprogramming in idiopathic pulmonary fibrosis
Title: The Oncogene ECT2 Contributes to a Hyperplastic, Proliferative Lung Epithelial Cell Phenotype in Idiopathic Pulmonary Fibrosis.
Loss of ECT2 expression is associated with myocardial Polyploidization Creating a Barrier to Heart Regeneration.
Title: Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish.
These results suggest that Ect2 plays roles in multiple aspects of DNA damage response.
Title: The dynamic behavior of Ect2 in response to DNA damage.
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Title: Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Ect2 may play a role in neuronal differentiation and brain development in vivo.
Title: Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells.
results demonstrate the functional role of Ect2 in postnatal proliferating cells in the two lobes of the pituitary, thereby suggesting roles in developmental growth of the mammalian pituitary
Title: Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary.
indispensable role of the maturation-promoting factor ECT2 pathwy in polar body extrusion in mouse oocytes
Title: Epithelial cell transforming protein 2 (ECT2) depletion blocks polar body extrusion and generates mouse oocytes containing two metaphase II spindles.
ECT2 has a role in activating the Rho signaling pathways leading to malignant transformation
Title: Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI528536 (e-PCR)
- UniSTS:178815

L11316 (e-PCR)
- UniSTS:124874

Ect2 (e-PCR), detects polymorphism
- UniSTS:527325

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in bicellular tight junction assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to ionizing radiation	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis, actomyosin contractile ring assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
part_of centralspindlin complex	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein ECT2

Names: epithelial cell-transforming sequence 2 oncogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177625.2 → NP_001171096.1 protein ECT2 isoform 2

See identical proteins and their annotated locations for NP_001171096.1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

Consensus CDS

CCDS50875.1

UniProtKB/TrEMBL

A0A2X0SFE3

Related

ENSMUSP00000135740.3, ENSMUST00000176242.9

Conserved Domains (4) summary

smart00325
Location:425 → 609

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01229
Location:600 → 773

PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain

cd17732
Location:239 → 318

BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

cd17733
Location:145 → 220

BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
NM_001177626.2 → NP_001171097.1 protein ECT2 isoform 2

See identical proteins and their annotated locations for NP_001171097.1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

Consensus CDS

CCDS50875.1

UniProtKB/TrEMBL

A0A2X0SFE3

Related

ENSMUSP00000103933.3, ENSMUST00000108298.9

Conserved Domains (4) summary

smart00325
Location:425 → 609

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01229
Location:600 → 773

PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain

cd17732
Location:239 → 318

BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

cd17733
Location:145 → 220

BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins
NM_001409697.1 → NP_001396626.1 protein ECT2 isoform 3

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409704.1 → NP_001396633.1 protein ECT2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

UniProtKB/Swiss-Prot

Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
NM_001409705.1 → NP_001396634.1 protein ECT2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

UniProtKB/Swiss-Prot

Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
NM_001409706.1 → NP_001396635.1 protein ECT2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

UniProtKB/Swiss-Prot

Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
NM_001409707.1 → NP_001396636.1 protein ECT2 isoform 13

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409708.1 → NP_001396637.1 protein ECT2 isoform 1

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

UniProtKB/Swiss-Prot

Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2
NM_001409709.1 → NP_001396638.1 protein ECT2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409710.1 → NP_001396639.1 protein ECT2 isoform 4

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409711.1 → NP_001396640.1 protein ECT2 isoform 16

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409712.1 → NP_001396641.1 protein ECT2 isoform 5

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409713.1 → NP_001396642.1 protein ECT2 isoform 2

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409714.1 → NP_001396643.1 protein ECT2 isoform 14

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409715.1 → NP_001396644.1 protein ECT2 isoform 15

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409716.1 → NP_001396645.1 protein ECT2 isoform 6

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409717.1 → NP_001396646.1 protein ECT2 isoform 17

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409718.1 → NP_001396647.1 protein ECT2 isoform 6

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409719.1 → NP_001396648.1 protein ECT2 isoform 7

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409720.1 → NP_001396649.1 protein ECT2 isoform 8

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409721.1 → NP_001396650.1 protein ECT2 isoform 9

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409722.1 → NP_001396651.1 protein ECT2 isoform 10

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409723.1 → NP_001396652.1 protein ECT2 isoform 11

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409724.1 → NP_001396653.1 protein ECT2 isoform 11

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_001409725.1 → NP_001396654.1 protein ECT2 isoform 12

Status: VALIDATED

Source sequence(s)

AC121099, AC165280
NM_007900.4 → NP_031926.2 protein ECT2 isoform 1

See identical proteins and their annotated locations for NP_031926.2

Status: VALIDATED

Source sequence(s)

AC121099, AC165280

Consensus CDS

CCDS17270.2

UniProtKB/Swiss-Prot

Q07139, Q3TZP2, Q5DTR8, Q80VE4, Q8CIH2, Q8K2A0, Q8R3E2

UniProtKB/TrEMBL

A0A2X0SFE3

Related

ENSMUSP00000103935.2, ENSMUST00000108300.8

Conserved Domains (5) summary

PRK09630
Location:71 → 125

PRK09630; DNA topoisomerase IV subunit A; Provisional

smart00325
Location:456 → 640

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases

cd01229
Location:631 → 804

PH_Ect2; Epithelial cell transforming 2 (Ect2) pleckstrin homology (PH) domain

cd17732
Location:270 → 349

BRCT_Ect2_rpt2; second BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins

cd17733
Location:176 → 251

BRCT_Ect2_rpt1; first BRCT domain of epithelial cell-transforming sequence 2 protein (ECT2) and similar proteins