Il22ra2 interleukin 22 receptor, alpha 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il22ra2provided by MGI
Official Full Name: interleukin 22 receptor, alpha 2provided by MGI
Primary source: MGI:MGI:2665114
See related: Ensembl:ENSMUSG00000039760 AllianceGenome:MGI:2665114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CRF2X; CRF2-10; CRF2-s1; Il-22bp
Summary: Predicted to enable interleukin-22 binding activity and interleukin-22 receptor activity. Acts upstream of or within negative regulation of inflammatory response and regulation of tyrosine phosphorylation of STAT protein. Located in cytosol. Orthologous to human IL22RA2 (interleukin 22 receptor subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 10 A3; 10 8.52 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (19497776..19510429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (19622028..19634681)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury.
Title: IL-22 Binding Protein Controls IL-22-Driven Bleomycin-Induced Lung Injury.
IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.
Title: IL-22RA2 Is a SMAD7 Target Mediating the Alleviation of Dermatitis and Psoriatic Phenotypes in Mice.
Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.
Title: Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.
Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Title: Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.
Our results demonstrate a pathogenic role of IL-22BP in three species with a potential mechanism of action involving T cell polarization
Title: IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
Together, these data indicate that IL-22BP deficiency enhances IL-22 signaling in the lung, thus contributing to resistance to pneumococcal pneumonia by downregulating OXPHOS genes and increasing glycolysis in macrophages.
Title: Interleukin-22 (IL-22) Binding Protein Constrains IL-22 Activity, Host Defense, and Oxidative Phosphorylation Genes during Pneumococcal Pneumonia.
This study used the TLR7 agonist Imiquimod (IMQ) to induce a psoriasis-like skin disease in mice and found a strong downregulation of IL-22BP in the affected skin as well as in the lymph nodes of animals treated with IMQ.
Title: Regulation of IL-22BP in psoriasis.
This study demonstrated that the IL-22/IL-22BP system plays a major role during Pseudomonas aeruginosa pneumonia by moderating neutrophil accumulation in the lungs that ultimately leads to epithelium protection.
Title: Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model.
limits the pathological manifestations in models of allergic contact dermatitis and psoriasis
Title: IL-22 binding protein regulates murine skin inflammation.
Il22bp-deficient mice were more susceptible to acute liver damage in models of acute liver damage induced by ischemia reperfusion and acetaminophen administration. IL-22BP plays a protective role in acute liver damage, via controlling IL-22-induced Cxcl10 expression.
Title: A Protective Function of IL-22BP in Ischemia Reperfusion and Acetaminophen-Induced Liver Injury.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-22 binding	ISO Inferred from Sequence Orthology more info
enables interleukin-22 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-22 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of tyrosine phosphorylation of STAT protein	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-22 receptor subunit alpha-2

Names: IL-22 receptor subunit alpha-2; IL-22R-alpha-2; IL-22RA2; IL22BP; cytokine receptor family II soluble 1; cytokine receptor family type 2, soluble 1; interleukin-22-binding protein; zcytoR16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178258.5 → NP_839989.2 interleukin-22 receptor subunit alpha-2 precursor

See identical proteins and their annotated locations for NP_839989.2

Status: PROVISIONAL

Source sequence(s)

AK138913

Consensus CDS

CCDS23717.1

UniProtKB/Swiss-Prot

Q3UU14, Q7TNI5, Q80XF5

UniProtKB/TrEMBL

Q08AV1, Q3UTW4, Q3V3G3

Related

ENSMUSP00000042642.8, ENSMUST00000036564.8

Conserved Domains (2) summary

pfam01108
Location:30 → 113

Tissue_fac; Tissue factor

pfam09294
Location:125 → 230

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III