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    Trmt6 tRNA methyltransferase 6 [ Mus musculus (house mouse) ]

    Gene ID: 66926, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trmt6provided by MGI
    Official Full Name
    tRNA methyltransferase 6provided by MGI
    Primary source
    MGI:MGI:1914176
    See related
    Ensembl:ENSMUSG00000037376 AllianceGenome:MGI:1914176
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CGI-09; mKIAA1153; 3300001M20Rik
    Summary
    Predicted to be involved in mRNA methylation. Predicted to act upstream of or within tRNA processing. Predicted to be part of tRNA (m1A) methyltransferase complex. Predicted to be active in nucleus. Is expressed in midbrain ventricular layer; olfactory epithelium; submandibular gland primordium; telencephalon ventricular layer; and thymus primordium. Orthologous to human TRMT6 (tRNA methyltransferase 6 non-catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.7), CNS E14 (RPKM 6.1) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trmt6 in Genome Data Viewer
    Location:
    2 F2; 2 64.74 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (132646127..132658127, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (132804207..132816054, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene shieldin complex subunit 1 Neighboring gene predicted gene, 52525 Neighboring gene predicted gene, 22245 Neighboring gene chromogranin B Neighboring gene STARR-positive B cell enhancer ABC_E4502 Neighboring gene minichromosome maintenance 8 homologous recombination repair factor Neighboring gene STARR-positive B cell enhancer ABC_E10152 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:132672271-132672472 Neighboring gene cardiolipin synthase 1 Neighboring gene leucine rich repeat neuronal 4 Neighboring gene predicted gene, 54154

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. tRNA-m(1)A modification promotes T cell expansion via efficient MYC protein synthesis. Liu Y, et al. Nat Immunol, 2022 Oct. PMID 36138184
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    3. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of tRNA (m1A) methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6
    Names
    mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6
    tRNA (adenine-N(1)-)-methyltransferase non-catalytic subunit TRM6
    tRNA methyltransferase 6 homolog
    tRNA(m1A58)-methyltransferase subunit TRM6
    tRNA(m1A58)MTase subunit TRM6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356442.1 → NP_001343371.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AL929562
      Conserved Domains (1) summary
      pfam04189
      Location:14 → 222
      Gcd10p; Gcd10p family

    2. NM_001356443.1 → NP_001343372.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction in the 5' end compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL929562
      Conserved Domains (1) summary
      pfam04189
      Location:1 → 82
      Gcd10p; Gcd10p family

    3. NM_001356444.1 → NP_001343373.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. The resulting isoform (4) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL929562
      Related
      ENSMUST00000147336.8
      Conserved Domains (1) summary
      pfam04189
      Location:1 → 70
      Gcd10p; Gcd10p family

    4. NM_175113.3 → NP_780322.2  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform 1

      See identical proteins and their annotated locations for NP_780322.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK028755
      Consensus CDS
      CCDS50728.1
      UniProtKB/Swiss-Prot
      Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CE96, Q8CEU0
      Related
      ENSMUSP00000044687.7, ENSMUST00000039554.7
      Conserved Domains (1) summary
      pfam04189
      Location:21 → 253
      Gcd10p; Gcd10p family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      132646127..132658127 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162501.1 → XP_036018394.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X1

      UniProtKB/Swiss-Prot
      Q3TJZ8, Q3TME7, Q6ZPW8, Q80Y59, Q8CE96, Q8CEU0
      Conserved Domains (1) summary
      pfam04189
      Location:21 → 253
      Gcd10p; Gcd10p family

    2. XM_030251972.1 → XP_030107832.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2

      Conserved Domains (1) summary
      pfam04189
      Location:1 → 70
      Gcd10p; Gcd10p family

    3. XM_036162502.1 → XP_036018395.1  tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 isoform X2

      Conserved Domains (1) summary
      pfam04189
      Location:1 → 70
      Gcd10p; Gcd10p family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CE96.1 GenPept UniProtKB/Swiss-Prot:Q8CE96

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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