Ptdss2 phosphatidylserine synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptdss2provided by MGI
Official Full Name: phosphatidylserine synthase 2provided by MGI
Primary source: MGI:MGI:1351664
See related: Ensembl:ENSMUSG00000025495 AllianceGenome:MGI:1351664
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSS2
Summary: Enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Acts upstream of or within phosphatidylserine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including heart; hemolymphoid system; liver; nervous system; and testis. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in testis adult (RPKM 133.4), liver E14.5 (RPKM 36.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.39 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (140711181..140736071)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141131267..141156158)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSS2 may play a key role in PS accumulation in brain and testis through high activity toward DHA-containing substrates that are abundant in these tissues
Title: Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid.
Pss2 is responsible for the majority of serine exchange activity in in vitro assays, but a deficiency in this enzyme does not cause perturbations in phospholipid content or severe developmental abnormalities
Title: Defining the importance of phosphatidylserine synthase 2 in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235803

NoName (e-PCR)
- UniSTS:235804

NoName (e-PCR)
- UniSTS:235805

NoName (e-PCR)
- UniSTS:235810

RH126410 (e-PCR)
- UniSTS:163118

Ptdss2 (e-PCR), detects polymorphism
- UniSTS:497494

AI988017 (e-PCR)
- UniSTS:179671

AI481134 (e-PCR)
- UniSTS:159715

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylserine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidylserine synthase 2

Names: PSS-2; ptdSer synthase 2; serine-exchange enzyme II

NP_001405348.1

EC 2.7.8.29

NP_001405349.1

EC 2.7.8.29

NP_038810.2

EC 2.7.8.29

XP_006536259.1

EC 2.7.8.29

XP_006536260.1

EC 2.7.8.29

XP_030098495.1

EC 2.7.8.29

XP_030098496.1

EC 2.7.8.29

XP_030098497.1

EC 2.7.8.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418419.1 → NP_001405348.1 phosphatidylserine synthase 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC108908, AC109272

Related

ENSMUST00000173721.8
NM_001418420.1 → NP_001405349.1 phosphatidylserine synthase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC108908, AC109272
NM_013782.5 → NP_038810.2 phosphatidylserine synthase 2 isoform1

See identical proteins and their annotated locations for NP_038810.2

Status: VALIDATED

Source sequence(s)

AC108908, AC109272

Consensus CDS

CCDS22001.1

UniProtKB/Swiss-Prot

Q8BHL2, Q8CCI8, Q8CCY7, Q922A1, Q9CY68, Q9Z1X2

Related

ENSMUSP00000026568.9, ENSMUST00000026568.10

Conserved Domains (1) summary

pfam03034
Location:98 → 377

PSS; Phosphatidyl serine synthase

RNA

NR_184740.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108908, AC109272
NR_184741.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108908, AC109272
NR_184742.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108908, AC109272
NR_184743.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC108908, AC109272

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

140711181..140736071

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242637.2 → XP_030098497.1 phosphatidylserine synthase 2 isoform X2

Conserved Domains (1) summary

pfam03034
Location:1 → 191

PSS; Phosphatidyl serine synthase
XM_006536196.5 → XP_006536259.1 phosphatidylserine synthase 2 isoform X1

Conserved Domains (1) summary

pfam03034
Location:55 → 308

PSS; Phosphatidyl serine synthase
XM_030242635.1 → XP_030098495.1 phosphatidylserine synthase 2 isoform X2

Conserved Domains (1) summary

pfam03034
Location:1 → 191

PSS; Phosphatidyl serine synthase
XM_006536197.2 → XP_006536260.1 phosphatidylserine synthase 2 isoform X2

See identical proteins and their annotated locations for XP_006536260.1

Conserved Domains (1) summary

pfam03034
Location:1 → 191

PSS; Phosphatidyl serine synthase
XM_030242636.1 → XP_030098496.1 phosphatidylserine synthase 2 isoform X2

Conserved Domains (1) summary

pfam03034
Location:1 → 191

PSS; Phosphatidyl serine synthase