Topaz1 testis and ovary specific PAZ domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Topaz1provided by MGI
Official Full Name: testis and ovary specific PAZ domain containing 1provided by MGI
Primary source: MGI:MGI:3779933
See related: Ensembl:ENSMUSG00000094985 AllianceGenome:MGI:3779933
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm9524
Summary: Acts upstream of or within several processes, including ncRNA transcription; positive regulation of meiotic cell cycle phase transition; and spermatogenesis. Predicted to be located in cytoplasm. Is expressed in germ cell of testis; ovary; and testis. Orthologous to human TOPAZ1 (testis and ovary specific TOPAZ 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 1.2) See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 73.1 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (122576264..122631200)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (122747199..122802135)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TOPAZ1, a germ cell specific factor, is essential for male meiotic progression.
Title: TOPAZ1, a germ cell specific factor, is essential for male meiotic progression.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within meiotic prophase I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pachytene	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatocyte division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatocyte division	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein TOPAZ1

Names: testis and ovary-specific PAZ domain gene 1; testis- and ovary-specific PAZ domain-containing protein 1; topaz 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.