Chil3 chitinase-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chil3provided by MGI
Official Full Name: chitinase-like 3provided by MGI
Primary source: MGI:MGI:1330860
See related: Ensembl:ENSMUSG00000040809 AllianceGenome:MGI:1330860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ym1; ECF-L; Chi3l3
Summary: The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]
Expression: Biased expression in lung adult (RPKM 97.4) and liver E18 (RPKM 36.9) See more
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Genomic context

Location:: 3 F2.2; 3 46.49 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (106054870..106074852, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (106147554..106167564, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ym1 protein crystals promote type 2 immunity.
Title: Ym1 protein crystals promote type 2 immunity.
Irreversible evolutionary loss of chitin-degrading ability in the chitinase-like protein Ym1 under positive selection in rodents.
Title: Irreversible evolutionary loss of chitin-degrading ability in the chitinase-like protein Ym1 under positive selection in rodents.
Pathological examination of Ym1, a chitinase family protein, in Mesocestoides corti-infected mice.
Title: Pathological examination of Ym1, a chitinase family protein, in Mesocestoides corti-infected mice.
An update on Ym1 and its immunoregulatory role in diseases.
Title: An update on Ym1 and its immunoregulatory role in diseases.
The Ym1(+)Ly6C(hi) monocytes greatly expanded in bone marrow during the recovery phase of systemic inflammation or tissue injury.
Title: Emergence of immunoregulatory Ym1(+)Ly6C(hi) monocytes during recovery phase of tissue injury.
Chi3l3 derived from macrophages, plays a key role in the infection of Angiostrongylus cantonensis, which in turn aggravates eosinophilic meningitis.
Title: Chi3l3: a potential key orchestrator of eosinophil recruitment in meningitis induced by Angiostrongylus cantonensis.
highly expressed in the subventricular zone, a stem cell niche of the adult brain, and in inflammatory brain lesions during experimental autoimmune encephalomyelitis
Title: Chi3l3 induces oligodendrogenesis in an experimental model of autoimmune neuroinflammation.
Ym1 and RELMalpha, exhibit time and dose-dependent interactions that determines the outcome of lung repair during nematode infection.
Title: Ym1 induces RELMα and rescues IL-4Rα deficiency in lung repair during nematode infection.
The soluble antigen from A. cantonensis could promote the Chil3 expression in macrophage and microglial cell lines induced by interleukin-13.
Title: Soluble antigen derived from IV larva of Angiostrongylus cantonensis promotes chitinase-like protein 3 (Chil3) expression induced by interleukin-13.
A significant increase of CHI3L3 mRNA expression was observed in the spinal cord of experimental autoimmune encephalitis mice compared to controls during the inflammatory phase.
Title: Breast regression protein-39 is not required for experimental autoimmune encephalomyelitis induction.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (7) 1 citation

General gene information

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Markers

Chi3l3 (e-PCR), detects polymorphism
- UniSTS:532614

AI505981 (e-PCR)
- UniSTS:165285

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetyl-beta-D-galactosaminidase activity	IEA Inferred from Electronic Annotation more info
enables beta-N-acetylhexosaminidase activity	IDA Inferred from Direct Assay more info	PubMed
enables carbohydrate binding	TAS Traceable Author Statement more info	PubMed
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
NOT enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polysaccharide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in production of molecular mediator involved in inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: chitinase-like protein 3

Names: beta-N-acetylhexosaminidase Ym1; eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; secreted protein Ym1

NP_034022.2

EC 3.2.1.52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009892.4 → NP_034022.2 chitinase-like protein 3 precursor

See identical proteins and their annotated locations for NP_034022.2

Status: VALIDATED

Source sequence(s)

AC125461

Consensus CDS

CCDS17718.1

UniProtKB/Swiss-Prot

O35744, P70201, Q3U462, Q3UV87, Q61201

Related

ENSMUSP00000053923.9, ENSMUST00000063062.9

Conserved Domains (2) summary

cd02872
Location:24 → 387

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

smart00636
Location:26 → 365

Glyco_18; Glyco_18 domain