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    Ptgr2 prostaglandin reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 77219, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Ptgr2provided by MGI
    Official Full Name
    prostaglandin reductase 2provided by MGI
    Primary source
    MGI:MGI:1916372
    See related
    Ensembl:ENSMUSG00000072946 AllianceGenome:MGI:1916372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PGR-2; PRG-2; Zadh1; 1810016I24Rik; 9130222H03Rik; 9630002F03Rik; B830026H24Rik
    Summary
    Predicted to enable 15-oxoprostaglandin 13-oxidase activity. Predicted to be involved in prostaglandin metabolic process. Located in mitochondrion. Orthologous to human PTGR2 (prostaglandin reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 20.2), kidney adult (RPKM 11.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 D1; 12 39.14 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84332011..84362606)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84285237..84315832)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene predicted gene, 46319 Neighboring gene STARR-seq mESC enhancer starr_32734 Neighboring gene ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10765 Neighboring gene zinc finger protein 410 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene family with sequence similarity 161, member B Neighboring gene STARR-positive B cell enhancer ABC_E1445 Neighboring gene coenzyme Q6 monooxygenase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution. Levin I, et al. Proteins, 2004 Aug 15. PMID 15229897
    2. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. Chou WL, et al. J Biol Chem, 2007 Jun 22. PMID 17449869
    3. TRIM67 protein negatively regulates Ras activity through degradation of 80K-H and induces neuritogenesis. Yaguchi H, et al. J Biol Chem, 2012 Apr 6. PMID 22337885, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 15-oxoprostaglandin-Delta13-reductase (PGR-2) catalyzes the reaction converting 15-keto-PGE2 to 13,14-dihydro-15-keto-PGE2
      Title: Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation.
    2. This mouse gene encodes a putative NADPH-dependent oxidoreductase. We report the crystal structure of the putative oxidoreductase determined by the semi-automated high-throughput pipeline of the Joint Center for Structural Genomics
      Title: Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 13-prostaglandin reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 13-prostaglandin reductase activity TAS
    Traceable Author Statement
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    prostaglandin reductase 2
    Names
    15-oxoprostaglandin 13-reductase
    zinc binding alcohol dehydrogenase, domain containing 1
    zinc-binding alcohol dehydrogenase domain-containing protein 1
    NP_001239554.1
    NP_001239555.1
    NP_084156.2
    XP_006516432.1
    XP_036013551.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001252625.1 → NP_001239554.1  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_001239554.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional segment in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK145232, AK159932, CD742484, CJ050177
      Consensus CDS
      CCDS36490.1
      UniProtKB/Swiss-Prot
      Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
      UniProtKB/TrEMBL
      Q3TXN1
      Related
      ENSMUSP00000119981.2, ENSMUST00000146377.8
      Conserved Domains (2) summary
      cd08293
      Location:1 → 345
      PTGR2; Prostaglandin reductase
      COG2130
      Location:4 → 347
      CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

    2. NM_001252626.1 → NP_001239555.1  prostaglandin reductase 2 isoform 2

      See identical proteins and their annotated locations for NP_001239555.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an additional exon in the 5' region, which includes an alternate AUG start codon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK007522, AK168895, CD742484, CJ050177
      UniProtKB/TrEMBL
      Q3TXN1
      Conserved Domains (1) summary
      cd08293
      Location:2 → 296
      PTGR2; Prostaglandin reductase

    3. NM_029880.3 → NP_084156.2  prostaglandin reductase 2 isoform 1

      See identical proteins and their annotated locations for NP_084156.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK159932, CD742484, CJ050177
      Consensus CDS
      CCDS36490.1
      UniProtKB/Swiss-Prot
      Q3TG36, Q3ULY3, Q8BZA2, Q8VDQ1, Q9D1W8
      UniProtKB/TrEMBL
      Q3TXN1
      Related
      ENSMUSP00000115704.2, ENSMUST00000123614.8
      Conserved Domains (2) summary
      cd08293
      Location:1 → 345
      PTGR2; Prostaglandin reductase
      COG2130
      Location:4 → 347
      CurA; NADPH-dependent curcumin reductase CurA [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      84332011..84362606
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516369.1 → XP_006516432.1  prostaglandin reductase 2 isoform X1

      UniProtKB/TrEMBL
      Q3TXN1
      Conserved Domains (1) summary
      cl16912
      Location:1 → 288
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family

    2. XM_036157658.1 → XP_036013551.1  prostaglandin reductase 2 isoform X2

      Conserved Domains (1) summary
      cl16912
      Location:2 → 239
      MDR; Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VDQ1.2 GenPept UniProtKB/Swiss-Prot:Q8VDQ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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