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    Lctl lactase-like [ Mus musculus (house mouse) ]

    Gene ID: 235435, updated on 4-May-2024

    Summary

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    Official Symbol
    Lctlprovided by MGI
    Official Full Name
    lactase-likeprovided by MGI
    Primary source
    MGI:MGI:2183549
    See related
    Ensembl:ENSMUSG00000032401 AllianceGenome:MGI:2183549
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KLPH; E130104I05Rik
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Involved in lens morphogenesis in camera-type eye. Located in brush border and endoplasmic reticulum. Orthologous to human LCTL (lactase like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 18.1), liver E14 (RPKM 5.9) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 C; 9 34.5 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64024399..64045400)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64117123..64138118)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Scarletltr, erythroid developmental long intergenic non-protein coding transcript Neighboring gene STARR-positive B cell enhancer ABC_E11410 Neighboring gene predicted gene, 39360 Neighboring gene zwilch kinetochore protein Neighboring gene STARR-seq mESC enhancer starr_24420 Neighboring gene small nucleolar RNA, C/D box 16A Neighboring gene predicted gene, 23344 Neighboring gene ribosomal protein L4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation. Fan J, et al. Exp Eye Res, 2018 Apr. PMID 29425878, Free PMC Article
    2. Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure. Ito S, et al. Biochim Biophys Acta, 2002 Jul 19. PMID 12084582
    3. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that KLPH is required for lens-specific expression of Clic5 and that Clic5 has an important role in the machinery that controls lens fiber cell extension and organization.
      Title: The klotho-related protein KLPH (lctl) has preferred expression in lens and is essential for expression of clic5 and normal lens suture formation.
    2. Results describe a novel mouse gene klph that encodes a novel mammalian family 1 glycosidase-like protein.
      Title: Identification of a novel mouse membrane-bound family 1 glycosidase-like protein, which carries an atypical active site structure.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lens morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within visual perception IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lactase-like protein
    Names
    Klotho-LPH related
    klotho/lactase-phlorizin hydrolase-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145835.3 → NP_665834.1  lactase-like protein precursor

      See identical proteins and their annotated locations for NP_665834.1

      Status: VALIDATED

      Source sequence(s)
      AC114674
      Consensus CDS
      CCDS23274.1
      UniProtKB/Swiss-Prot
      Q8BPR1, Q8K1F9, Q8K2M9
      Related
      ENSMUSP00000034969.8, ENSMUST00000034969.14
      Conserved Domains (1) summary
      cl23725
      Location:32 → 502
      Glyco_hydro_1; Glycosyl hydrolase family 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64024399..64045400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511101.5 → XP_006511164.1  lactase-like protein isoform X1

      Conserved Domains (1) summary
      cl23725
      Location:34 → 498
      Glyco_hydro; Glycosyl hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1F9.1 GenPept UniProtKB/Swiss-Prot:Q8K1F9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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