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    Kif26a kinesin family member 26A [ Mus musculus (house mouse) ]

    Gene ID: 668303, updated on 9-May-2024

    Summary

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    Official Symbol
    Kif26aprovided by MGI
    Official Full Name
    kinesin family member 26Aprovided by MGI
    Primary source
    MGI:MGI:2447072
    See related
    Ensembl:ENSMUSG00000021294 AllianceGenome:MGI:2447072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1236
    Summary
    Enables microtubule binding activity. Involved in enteric nervous system development; negative regulation of signal transduction; and regulation of cell growth by extracellular stimulus. Predicted to be located in cytoplasm and cytoskeleton. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in central nervous system; ganglia; and intestine. Orthologous to human KIF26A (kinesin family member 26A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 14.0), whole brain E14.5 (RPKM 13.1) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    12 F1; 12 61.14 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112109378..112148181)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112143974..112181747)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene microRNA 3073a Neighboring gene microRNA 3073b Neighboring gene asparaginase Neighboring gene microRNA 203b Neighboring gene microRNA 203 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33350 Neighboring gene predicted gene, 36894

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice. Ohara Y, et al. Sci Rep, 2021 Feb 4. PMID 33542431, Free PMC Article
    2. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon. Almannai M, et al. Hum Genet, 2023 Mar. PMID 36564622
    3. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Qian X, et al. Dev Cell, 2022 Oct 24. PMID 36228617, Free PMC Article
    4. The Atypical Kinesin KIF26A Facilitates Termination of Nociceptive Responses by Sequestering Focal Adhesion Kinase. Wang L, et al. Cell Rep, 2018 Sep 11. PMID 30208315
    5. KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Zhou R, et al. Cell, 2009 Nov 13. PMID 19914172

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
      Title: KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
    2. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
      Title: Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
    3. Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
      Title: Genetic background-dependent abnormalities of the enteric nervous system and intestinal function in Kif26a-deficient mice.
    4. Mice with a homozygous deletion of Kif26a developed a megacolon with enteric nerve hyperplasia. Kif26a-/- enteric neurons showed hypersensitivity for GDNF-Ret signaling
      Title: KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1236

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cerebral cortex development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in enteric nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in microtubule-based movement IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell growth by extracellular stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF26A
    Names
    N-11 kinesin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097621.1 → NP_001091090.1  kinesin-like protein KIF26A

      See identical proteins and their annotated locations for NP_001091090.1

      Status: VALIDATED

      Source sequence(s)
      BC059062, BC094358, BM963109, CB518589, CB520233, CD348409, CD350871, CD352284, CJ130134
      Consensus CDS
      CCDS49186.1
      UniProtKB/Swiss-Prot
      C9EF47, Q52KG5, Q6PCY3, Q6ZPV4, Q99PT4
      Related
      ENSMUSP00000119482.2, ENSMUST00000128402.3
      Conserved Domains (2) summary
      smart00129
      Location:365 → 725
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00106
      Location:364 → 716
      KISc; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112109378..112148181
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516162.4 → XP_006516225.1  kinesin-like protein KIF26A isoform X1

      Conserved Domains (3) summary
      PHA03247
      Location:1154 → 1647
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:869 → 1301
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00106
      Location:396 → 748
      KISc; Kinesin motor domain

    2. XM_036157581.1 → XP_036013474.1  kinesin-like protein KIF26A isoform X2

      Conserved Domains (3) summary
      PHA03247
      Location:860 → 1353
      PHA03247; large tegument protein UL36; Provisional
      PRK07764
      Location:575 → 1007
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      cd00106
      Location:102 → 454
      KISc; Kinesin motor domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KG5.2 GenPept UniProtKB/Swiss-Prot:Q52KG5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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