Itgb7 integrin beta 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Itgb7provided by MGI
Official Full Name: integrin beta 7provided by MGI
Primary source: MGI:MGI:96616
See related: Ensembl:ENSMUSG00000001281 AllianceGenome:MGI:96616
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly69
Summary: Predicted to enable integrin binding activity. Acts upstream of or within T cell migration. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin alpha4-beta7 complex. Predicted to be active in cell surface and focal adhesion. Is expressed in genitourinary system and thymus primordium. Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 26.7), mammary gland adult (RPKM 11.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F2; 15 57.39 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (102124429..102141840, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (102215994..102233405, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct bidirectional regulation of LFA1 and alpha4beta7 by Rap1 and integrin adaptors in T cells under shear flow.
Title: Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow.
An integrin alphaEbeta7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.
Title: An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.
Dual targeting of lymphocyte homing and retention through alpha4beta7 and alphaEbeta7 inhibition in inflammatory bowel disease.
Title: Dual targeting of lymphocyte homing and retention through α4β7 and αEβ7 inhibition in inflammatory bowel disease.
beta7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells.
Title: β7 Integrin Inhibition Can Increase Intestinal Inflammation by Impairing Homing of CD25(hi)FoxP3(+) Regulatory T Cells.
Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Title: Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.
Transmission of integrin beta7 transmembrane domain topology enables gut lymphoid tissue development.
Title: Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.
lack of beta7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival.
Title: β7 integrins contribute to intestinal tumor growth in mice.
Loss of MAdCAM-1 has beneficial effects regarding the development of NASH - manifested by reduced hepatic oxidative stress and decreased inflammation. In contrast, beta7-Integrin-deficiency results in increased steatohepatitis.
Title: β(7)-Integrin and MAdCAM-1 play opposing roles during the development of non-alcoholic steatohepatitis.
AEbeta7 is of key relevance for gut trafficking of inflammatory bowel disease (IBD) CD8(+) T cells and CD4(+) Th9 cells in vivo and mainly retention might account for this effect. These findings indicate that blockade of alphaEbeta7 in addition to alpha4beta7 may be particularly effective in intestinal disorders with expansion of CD8(+) and Th9 cells such as IBD.
Title: Blockade of αEβ7 integrin suppresses accumulation of CD8(+) and Th9 lymphocytes from patients with IBD in the inflamed gut in vivo.
Glycosylation of V1V2 domain of HIV envelope protein determined its binding to alpha4ss7 integrin.
Title: Glycosylation and oligomeric state of envelope protein might influence HIV-1 virion capture by α4β7 integrin.

Submit: New GeneRIF Correction See all GeneRIFs (45)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

M68903 (e-PCR)
- UniSTS:160513

NoName (e-PCR)
- UniSTS:224876

D9S759 (e-PCR)
- UniSTS:149125

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin alpha4-beta7 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: integrin beta-7

Names: M290 IEL antigen; integrin beta-P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013566.2 → NP_038594.2 integrin beta-7 precursor

See identical proteins and their annotated locations for NP_038594.2

Status: VALIDATED

Source sequence(s)

AI322899, AK078871, AK155594

Consensus CDS

CCDS49740.1

UniProtKB/Swiss-Prot

P26011, Q3U2M1, Q64656

Related

ENSMUSP00000001327.4, ENSMUST00000001327.11

Conserved Domains (4) summary

smart00187
Location:50 → 476

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07965
Location:645 → 716

Integrin_B_tail; Integrin beta tail domain

pfam07974
Location:607 → 635

EGF_2; EGF-like domain

pfam08725
Location:749 → 790

Integrin_b_cyt; Integrin beta cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

102124429..102141840 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520482.2 → XP_006520545.1 integrin beta-7 isoform X1

Conserved Domains (4) summary

smart00187
Location:50 → 476

INB; Integrin beta subunits (N-terminal portion of extracellular region)

pfam07974
Location:607 → 635

EGF_2; EGF-like domain

pfam07965
Location:645 → 716

Integrin_B_tail; Integrin beta tail domain

pfam18372
Location:480 → 506

I-EGF_1; Integrin beta epidermal growth factor like domain 1
XM_017316440.1 → XP_017171929.1 integrin beta-7 isoform X2