CCNY cyclin Y [Homo sapiens (human)] - Gene

Summary

Official Symbol: CCNYprovided by HGNC
Official Full Name: cyclin Yprovided by HGNC
Primary source: HGNC:HGNC:23354
See related: Ensembl:ENSG00000108100 MIM:612786; AllianceGenome:HGNC:23354
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCNX; CFP1; CBCP1; C10orf9
Summary: Cyclins, such as CCNY, control cell division cycles and regulate cyclin-dependent kinases (e.g., CDC2; MIM 116940) (Li et al., 2009 [PubMed 18060517]).[supplied by OMIM, May 2009]
Expression: Ubiquitous expression in testis (RPKM 35.4), brain (RPKM 17.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 10p11.21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (35247025..35572667)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (35275620..35601106)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (35535953..35861595)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of cyclin Y in normal and pathological cells.
Title: The role of cyclin Y in normal and pathological cells.
Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Title: Cyclin Y binds and activates CDK4 to promote the G1/S phase transition in hepatocellular carcinoma cells via Rb signaling.
Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling.
Title: Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling.
Fisetin inhibits TET1 expression and reduces 5hmC modification in specific loci in the promoters of CCNY/CDK16 in HuRSCs.
Title: Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell.
Cyclin Y and CDK16 complex is necessary for efficient AMPK-dependent activation of autophagy.This functional interaction is mediated by AMPK phosphorylating Serine 326 of Cyclin Y.
Title: AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy.
increased expression of CCNY was significantly associated with cell proliferation and migration.
Title: Cyclin Y Modulates the Proliferation, Invasion, and Metastasis of Hepatocellular Carcinoma Cells.
Amplification of gene CCNY is associated with metastatic lung adenocarcinoma.
Title: The genomic dynamics during progression of lung adenocarcinomas.
findings revealed an unrecognized role of Caprin-2 in facilitating LRP5/6 constitutive phosphorylation at G2/M through forming a quaternary complex with CDK14, Cyclin Y, and LRP5/6.
Title: Activation/Proliferation-associated Protein 2 (Caprin-2) Positively Regulates CDK14/Cyclin Y-mediated Lipoprotein Receptor-related Protein 5 and 6 (LRP5/6) Constitutive Phosphorylation.
we believe that CCNY has biological effect in breast cancer (BC) development, and its inhibition via an RNA interference lentiviral system may provide a therapeutic option for BC
Title: RNAi-mediated downregulation of cyclin Y to attenuate human breast cancer cell growth.
CCNY was significantly upregulated in ovarian cancer cell lines and tissues. Significant association was observed between CCNY expression and clinicopathological stage and lymph node metastasis. It significantly exacerbated proliferation, migration, and invasion of A2780 cells, in vitro and in nude mice. It significantly increased c-Myc, cyclin D1, PFTK1, ki67, and OGT protein expressions in xenograft tumor tissues.
Title: Cyclin Y regulates the proliferation, migration, and invasion of ovarian cancer cells via Wnt signaling pathway.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB071127 (e-PCR)
- UniSTS:480038

RH122534 (e-PCR)
- UniSTS:138536

RH70372 (e-PCR)
- UniSTS:50743

G20748 (e-PCR)
- UniSTS:56887

A006E35 (e-PCR)
- UniSTS:56888

RH104302 (e-PCR)
- UniSTS:98627

RH15706 (e-PCR)
- UniSTS:17477

STS-T95622 (e-PCR)
- UniSTS:585

D10S1868 (e-PCR)
- UniSTS:2131

NoName (e-PCR)
- UniSTS:484437

D10S1402E (e-PCR)
- UniSTS:151400

STS-H67136 (e-PCR)
- UniSTS:8072

A010B05 (e-PCR)
- UniSTS:8073

G33065 (e-PCR)
- UniSTS:117641

D10S1247 (e-PCR), detects polymorphism
- UniSTS:39315

SHGC-32774 (e-PCR)
- UniSTS:45723

RH48798 (e-PCR)
- UniSTS:3232

RH47247 (e-PCR)
- UniSTS:29112

D10S2357 (e-PCR)
- UniSTS:81095

HSC1TD072 (e-PCR)
- UniSTS:2261

D10S1163 (e-PCR)
- UniSTS:58856

SGC30806 (e-PCR)
- UniSTS:65264

G65595 (e-PCR)
- UniSTS:225529

G20724 (e-PCR)
- UniSTS:60670

A006D26 (e-PCR)
- UniSTS:60671

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermatogenesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleus	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-Y

Names: cyc-Y; cyclin box protein 1; cyclin fold protein 1; cyclin-X; cyclin-box carrying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001282852.2 → NP_001269781.1 cyclin-Y isoform 3

See identical proteins and their annotated locations for NP_001269781.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AA476431, AF413522, AF465728, AL117336, AL121749, BC094815

Consensus CDS

CCDS60513.1

UniProtKB/TrEMBL

B2RBH6

Related

ENSP00000344275.5, ENST00000339497.7

Conserved Domains (1) summary

cd20540
Location:141 → 237

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
NM_001282853.2 → NP_001269782.1 cyclin-Y isoform 2

See identical proteins and their annotated locations for NP_001269782.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.

Source sequence(s)

AA476431, AF413522, AL117336, AL121749, BC050310, BC094815

Consensus CDS

CCDS7190.1

UniProtKB/TrEMBL

B2RBH6

Related

ENSP00000265375.9, ENST00000265375.13

Conserved Domains (1) summary

cd20540
Location:112 → 208

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
NM_001282854.2 → NP_001269783.1 cyclin-Y isoform 5

See identical proteins and their annotated locations for NP_001269783.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AA476431, AF413522, AK303283, AL117336, AL121749, BC094815

UniProtKB/TrEMBL

B7Z8E4

Conserved Domains (1) summary

pfam00134
Location:10 → 132

Cyclin_N; Cyclin, N-terminal domain
NM_145012.6 → NP_659449.3 cyclin-Y isoform 1

See identical proteins and their annotated locations for NP_659449.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AA476431, AF413522, AL117336, AL121749, BC094815

Consensus CDS

CCDS7189.1

UniProtKB/Swiss-Prot

B7ZKX9, D3DRY9, Q2M3V4, Q2TU96, Q6NT86, Q7Z4U7, Q8ND76, Q8TEX2, Q8TEX3, Q96M99, Q96P45

UniProtKB/TrEMBL

B2RBH6

Related

ENSP00000363836.4, ENST00000374704.8

Conserved Domains (1) summary

cd20540
Location:166 → 262

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
NM_181698.4 → NP_859049.2 cyclin-Y isoform 2

See identical proteins and their annotated locations for NP_859049.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. Variants 2 and 4 encode the same isoform (2), which has a shorter N-terminus than isoform 1.

Source sequence(s)

AA476431, AF429969, AK057280, AL121749

Consensus CDS

CCDS7190.1

UniProtKB/TrEMBL

B2RBH6

Related

ENSP00000363838.1, ENST00000374706.5

Conserved Domains (1) summary

cd20540
Location:112 → 208

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family