ANXA1 annexin A1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANXA1provided by HGNC
Official Full Name: annexin A1provided by HGNC
Primary source: HGNC:HGNC:533
See related: Ensembl:ENSG00000135046 MIM:151690; AllianceGenome:HGNC:533
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANX1; LPC1
Summary: This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014]
Expression: Biased expression in esophagus (RPKM 2850.3), bone marrow (RPKM 574.5) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q21.13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (73151865..73170393)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (85303301..85321829)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (75766781..75785309)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review).
Title: An overview of the regulatory role of annexin A1 in the tumor microenvironment and its prospective clinical application (Review).
Annexin A1 may contribute to the morphological changes in podocytes by mediating endocytic vesicle fusion and transport via promotion of SNARE assembly in idiopathic membranous nephropathy.
Title: Annexin A1 may contribute to the morphological changes in podocytes by mediating endocytic vesicle fusion and transport via promotion of SNARE assembly in idiopathic membranous nephropathy.
Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment.
Title: Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment.
The expression of annexin-A1 in esophageal squamous cell carcinoma and its association with the biological behavior of the primary human esophageal squamous carcinoma cell line.
Title: The expression of annexin-A1 in esophageal squamous cell carcinoma and its association with the biological behavior of the primary human esophageal squamous carcinoma cell line.
Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s.
Title: Annexin A1 is a cell-intrinsic metalloregulator of zinc in human ILC2s.
ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
Title: ANXA1 Promotes Tumor Immune Evasion by Binding PARP1 and Upregulating Stat3-Induced Expression of PD-L1 in Multiple Cancers.
Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis.
Title: Tissue plasminogen activator receptor ANXA2 and its complementary regulator anti-inflammatory ANXA1 as prognostic indicators of inflammatory response in COVID-19 pathogenesis.
Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Title: Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.
Salivary annexin A1: A candidate biomarker for periodontitis.
Title: Salivary annexin A1: A candidate biomarker for periodontitis.
The Multifaceted Role of Annexin A1 in Viral Infections.
Title: The Multifaceted Role of Annexin A1 in Viral Infections.

Submit: New GeneRIF Correction See all GeneRIFs (286)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of annexin A4 and V in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-13051 (e-PCR)
- UniSTS:1028

RH68409 (e-PCR)
- UniSTS:3341

G32952 (e-PCR)
- UniSTS:117530

STS-U25414 (e-PCR)
- UniSTS:64820

SHGC-12349 (e-PCR)
- UniSTS:78440

STS-H67867 (e-PCR)
- UniSTS:29146

A009X30 (e-PCR)
- UniSTS:5599

ANXA1 (e-PCR)
- UniSTS:509949

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cadherin binding involved in cell-cell adhesion	HDA more info	PubMed
enables calcium ion binding	EXP Inferred from Experiment more info	PubMed
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	EXP Inferred from Experiment more info	PubMed
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in alpha-beta T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to vascular endothelial growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in granulocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in localization	EXP Inferred from Experiment more info	PubMed
involved_in monocyte chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in myoblast migration involved in skeletal muscle regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T-helper 2 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of interleukin-8 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil activation	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide cross-linking	IDA Inferred from Direct Assay more info	PubMed
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T-helper 1 cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-2 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neutrophil apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of wound healing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of leukocyte migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	HDA more info	PubMed
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in cornified envelope	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in early endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in vesicle	HDA more info	PubMed
is_active_in vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: annexin A1

Names: annexin I (lipocortin I); annexin-1; calpactin II; calpactin-2; chromobindin-9; epididymis secretory sperm binding protein; phospholipase A2 inhibitory protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_000700.3 → NP_000691.1 annexin A1

See identical proteins and their annotated locations for NP_000691.1

Status: REVIEWED

Source sequence(s)

AA039737, AL359997, X05908

Consensus CDS

CCDS6645.1

UniProtKB/Swiss-Prot

B5BU38, P04083

UniProtKB/TrEMBL

A0A4D5RAJ5, Q5TZZ9

Related

ENSP00000257497.6, ENST00000257497.11

Conserved Domains (1) summary

pfam00191
Location:118 → 183

Annexin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000009.12 Reference GRCh38.p14 Primary Assembly

Range

73151865..73170393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017014657.2 → XP_016870146.1 annexin A1 isoform X1

UniProtKB/TrEMBL

A0A4D5RA86

Conserved Domains (1) summary

pfam00191
Location:129 → 194

Annexin; Annexin