NFIB nuclear factor I B [Homo sapiens (human)] - Gene

Summary

Official Symbol: NFIBprovided by HGNC
Official Full Name: nuclear factor I Bprovided by HGNC
Primary source: HGNC:HGNC:7785
See related: Ensembl:ENSG00000147862 MIM:600728; AllianceGenome:HGNC:7785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9p23-p22.3

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (14081843..14532077, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (14091330..14541744, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (14081842..14532075, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
Title: Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6-catalyzed metabolism of solanidine.
CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.
Title: CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.
NFIB facilitates replication licensing by acting as a genome organizer.
Title: NFIB facilitates replication licensing by acting as a genome organizer.
Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.
Title: Marked intrafamilial variability of clinical and neuroimaging manifestations in NFIB-related developmental disorder.
Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.
Title: Transcriptional regulation of NDUFA4L2 by NFIB induces sorafenib resistance by decreasing reactive oxygen species in hepatocellular carcinoma.
Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
Title: Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.
Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
Title: Impact of NFIB and CYP1A variants on clozapine serum concentration-A retrospective naturalistic cohort study on 526 patients with known smoking habits.
Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
Title: Exosomal miR-626 promotes the malignant behavior of oral cancer cells by targeting NFIB.
The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
Title: The Polymorphic Nuclear Factor NFIB Regulates Hepatic CYP2D6 Expression and Influences Risperidone Metabolism in Psychiatric Patients.
Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.
Title: Transcriptional Regulation of RIP2 Gene by NFIB Is Associated with Cellular Immune and Inflammatory Response to APEC Infection.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Macrocephaly, acquired, with impaired intellectual development MedGen: C4748993 OMIM: 618286 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of NFI-B by shRNA enhances HIV-1 replication in peripheral blood mononuclear cells (PBMCs) and in Jurkat cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH123249 (e-PCR)
- UniSTS:138014

A004O32 (e-PCR)
- UniSTS:83500

SHGC-152211 (e-PCR)
- UniSTS:184108

SHGC-151148 (e-PCR)
- UniSTS:173398

Nfib (e-PCR), detects polymorphism
- UniSTS:527449

RH118871 (e-PCR)
- UniSTS:138851

RH78074 (e-PCR)
- UniSTS:14692

SHGC-86156 (e-PCR)
- UniSTS:104804

D9S274 (e-PCR), detects polymorphism
- UniSTS:77675

D9S1869 (e-PCR), detects polymorphism
- UniSTS:32628

RH104353 (e-PCR)
- UniSTS:98678

RH120407 (e-PCR)
- UniSTS:132218

RH122803 (e-PCR)
- UniSTS:135038

MARC_17865-17866:1025013775:1 (e-PCR)
- UniSTS:268427

D9S274 (e-PCR), detects polymorphism
- UniSTS:80030

D8S1564E (e-PCR)
- UniSTS:153761

A006V16 (e-PCR)
- UniSTS:41122

EST12E1 (e-PCR)
- UniSTS:263076

D9S2012 (e-PCR)
- UniSTS:82852

SHGC-149957 (e-PCR)
- UniSTS:177331

SHGC-82205 (e-PCR)
- UniSTS:103102

RH80854 (e-PCR)
- UniSTS:89539

SHGC-146176 (e-PCR)
- UniSTS:175057

RH119845 (e-PCR)
- UniSTS:133590

D9S1065E (e-PCR)
- UniSTS:151282

WI-14235 (e-PCR)
- UniSTS:80885

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in anterior commissure morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation involved in salivary gland development	IEA Inferred from Electronic Annotation more info
involved_in cell proliferation in forebrain	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in club cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in commissural neuron axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in exit from mitosis	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in glandular epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell fate specification	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in hindbrain development	IEA Inferred from Electronic Annotation more info
involved_in lung ciliated cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of epithelial cell proliferation involved in lung morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell proliferation involved in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuron fate specification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in principal sensory nucleus of trigeminal nerve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regeneration	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in response to wounding	IEA Inferred from Electronic Annotation more info
involved_in retina development in camera-type eye	IEA Inferred from Electronic Annotation more info
involved_in salivary gland cavitation	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in type I pneumocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in type II pneumocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cerebellar mossy fiber	ISS Inferred from Sequence or Structural Similarity more info
part_of chromatin	ISA Inferred from Sequence Alignment more info
located_in fibrillar center	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear factor 1 B-type

Names: CCAAT-box-binding transcription factor; TGGCA-binding protein; nuclear factor 1/B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190737.2 → NP_001177666.1 nuclear factor 1 B-type isoform 1

See identical proteins and their annotated locations for NP_001177666.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AI140312, AL136366, AL441963, BX648845

Consensus CDS

CCDS55291.1

UniProtKB/TrEMBL

Q5VW26

Related

ENSP00000370340.1, ENST00000380953.6

Conserved Domains (3) summary

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam00859
Location:209 → 493

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:9 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
NM_001190738.2 → NP_001177667.1 nuclear factor 1 B-type isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) has multiple differences, one of which results in translation from an upstream start codon, compared to variant 1. The resulting protein (isoform 2) has a different and longer N-terminus and a shorter C-terminus when it is compared to isoform 1.

Source sequence(s)

AK131233, AL136366, AL137017, AL441963

Consensus CDS

CCDS55292.1

UniProtKB/TrEMBL

A0A0A0MRX8, A0A1B0GWJ4

Related

ENSP00000370321.4, ENST00000380934.8

Conserved Domains (3) summary

cl00055
Location:95 → 199

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam00859
Location:235 → 441

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:37 → 73

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
NM_001282787.2 → NP_001269716.1 nuclear factor 1 B-type isoform 4

See identical proteins and their annotated locations for NP_001269716.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region and contains an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter compared to isoform 1.

Source sequence(s)

AI140312, AL441963, BP372854, BX648416

Consensus CDS

CCDS65007.1

UniProtKB/Swiss-Prot

O00712

Related

ENSP00000442888.1, ENST00000543693.5

Conserved Domains (1) summary

pfam00859
Location:1 → 237

CTF_NFI; CTF/NF-I family transcription modulation region
NM_001369458.1 → NP_001356387.1 nuclear factor 1 B-type isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes the longest isoform (5).

Source sequence(s)

AL136366, AL159169, AL441963

UniProtKB/TrEMBL

Q5VW26

Conserved Domains (3) summary

pfam00859
Location:231 → 520

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:32 → 69

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:91 → 195

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369459.1 → NP_001356388.1 nuclear factor 1 B-type isoform 6

Status: VALIDATED

Source sequence(s)

AL136366, AL159169, AL441963

UniProtKB/TrEMBL

Q5VW26

Conserved Domains (3) summary

pfam00859
Location:231 → 511

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:32 → 69

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:91 → 195

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369460.1 → NP_001356389.1 nuclear factor 1 B-type isoform 7

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94389.1

UniProtKB/TrEMBL

A0A2R8Y7V8, Q5VW26

Related

ENSP00000496424.1, ENST00000646622.1

Conserved Domains (3) summary

pfam00859
Location:205 → 494

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:65 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369461.1 → NP_001356390.1 nuclear factor 1 B-type isoform 8

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94386.1

UniProtKB/TrEMBL

Q5VW26, Q5VW30

Related

ENSP00000380705.3, ENST00000397575.7

Conserved Domains (3) summary

pfam00859
Location:209 → 489

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369462.1 → NP_001356391.1 nuclear factor 1 B-type isoform 9

Status: VALIDATED

Source sequence(s)

AL136366, AL159169, AL441963

UniProtKB/TrEMBL

A0A1B0GWI9

Conserved Domains (4) summary

pfam00859
Location:231 → 438

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:32 → 69

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:91 → 195

MH1; N-terminal Mad Homology 1 (MH1) domain

cl30265
Location:407 → 497

PRK09579; multidrug efflux protein; Reviewed
NM_001369463.1 → NP_001356392.1 nuclear factor 1 B-type isoform 10

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

Q5VW26

Conserved Domains (3) summary

pfam00859
Location:205 → 466

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:65 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369464.1 → NP_001356393.1 nuclear factor 1 B-type isoform 11

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94385.1

UniProtKB/TrEMBL

A0A1B0GWI9, Q5VW27

Related

ENSP00000380709.2, ENST00000397579.6

Conserved Domains (4) summary

pfam00859
Location:209 → 416

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain

cl30265
Location:385 → 475

PRK09579; multidrug efflux protein; Reviewed
NM_001369465.1 → NP_001356394.1 nuclear factor 1 B-type isoform 12

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

Q5VW26

Conserved Domains (3) summary

pfam00859
Location:200 → 484

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:1 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 164

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369466.1 → NP_001356395.1 nuclear factor 1 B-type isoform 13

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWI9

Related

ENSP00000490945.1, ENST00000635877.1

Conserved Domains (4) summary

pfam00859
Location:205 → 412

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:65 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain

cl30265
Location:381 → 471

PRK09579; multidrug efflux protein; Reviewed
NM_001369467.1 → NP_001356396.1 nuclear factor 1 B-type isoform 14

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94384.1

UniProtKB/TrEMBL

A0A1B0GU97, A0A1B0GWI9

Related

ENSP00000490020.1, ENST00000637640.1

Conserved Domains (4) summary

PRK15127
Location:376 → 466

PRK15127; multidrug efflux RND transporter permease subunit AcrB

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 164

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam00859
Location:200 → 407

CTF_NFI; CTF/NF-I family transcription modulation region
NM_001369468.1 → NP_001356397.1 nuclear factor 1 B-type isoform 15

Status: VALIDATED

Source sequence(s)

AL136366, AL159169, AL441963

UniProtKB/TrEMBL

A0A1B0GWJ4

Conserved Domains (3) summary

pfam00859
Location:231 → 437

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:32 → 69

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:91 → 195

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369469.1 → NP_001356398.1 nuclear factor 1 B-type isoform 16

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWI9

Conserved Domains (3) summary

pfam00859
Location:161 → 368

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 125

MH1; N-terminal Mad Homology 1 (MH1) domain

cl30265
Location:337 → 427

PRK09579; multidrug efflux protein; Reviewed
NM_001369470.1 → NP_001356399.1 nuclear factor 1 B-type isoform 17

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94390.1

UniProtKB/TrEMBL

A0A1B0GVN4

Related

ENSP00000490588.1, ENST00000636432.1

Conserved Domains (3) summary

pfam10524
Location:3 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:64 → 116

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam00859
Location:130 → 419

CTF_NFI; CTF/NF-I family transcription modulation region
NM_001369471.1 → NP_001356400.1 nuclear factor 1 B-type isoform 18

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWJ4

Conserved Domains (3) summary

pfam00859
Location:209 → 414

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369472.1 → NP_001356401.1 nuclear factor 1 B-type isoform 19

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94388.1

UniProtKB/TrEMBL

A0A1B0GWJ4, U3KQE8

Related

ENSP00000475813.2, ENST00000606230.2

Conserved Domains (3) summary

pfam00859
Location:205 → 411

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:65 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369473.1 → NP_001356402.1 nuclear factor 1 B-type isoform 20

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWJ4

Conserved Domains (3) summary

pfam00859
Location:205 → 410

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:65 → 169

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369474.1 → NP_001356403.1 nuclear factor 1 B-type isoform 21

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWJ4

Conserved Domains (3) summary

pfam00859
Location:204 → 409

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:64 → 168

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369475.1 → NP_001356404.1 nuclear factor 1 B-type isoform 22

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWI9

Conserved Domains (4) summary

pfam00859
Location:134 → 341

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:68 → 120

MH1; N-terminal Mad Homology 1 (MH1) domain

cl30265
Location:310 → 400

PRK09579; multidrug efflux protein; Reviewed
NM_001369476.1 → NP_001356405.1 nuclear factor 1 B-type isoform 23

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94383.1

UniProtKB/TrEMBL

A0A1B0GW37, A0A1B0GWJ4

Related

ENSP00000490762.1, ENST00000636057.1

Conserved Domains (3) summary

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 164

MH1; N-terminal Mad Homology 1 (MH1) domain

pfam00859
Location:200 → 406

CTF_NFI; CTF/NF-I family transcription modulation region
NM_001369477.1 → NP_001356406.1 nuclear factor 1 B-type isoform 24

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

UniProtKB/TrEMBL

A0A1B0GWJ4

Conserved Domains (3) summary

pfam00859
Location:191 → 396

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369478.1 → NP_001356407.1 nuclear factor 1 B-type isoform 25

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Conserved Domains (3) summary

pfam00859
Location:130 → 336

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:4 → 43

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:64 → 116

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001369479.1 → NP_001356408.1 nuclear factor 1 B-type isoform 26

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Consensus CDS

CCDS94382.1

UniProtKB/TrEMBL

A0A1B0GWB8

Related

ENSP00000490864.1, ENST00000636735.1

Conserved Domains (2) summary

pfam00859
Location:30 → 237

CTF_NFI; CTF/NF-I family transcription modulation region

cl30265
Location:206 → 296

PRK09579; multidrug efflux protein; Reviewed
NM_001369480.1 → NP_001356409.1 nuclear factor 1 B-type isoform 27

Status: VALIDATED

Source sequence(s)

AL136366, AL441963

Conserved Domains (1) summary

pfam00859
Location:30 → 236

CTF_NFI; CTF/NF-I family transcription modulation region
NM_001369481.1 → NP_001356410.1 nuclear factor 1 B-type isoform 28

Status: VALIDATED

Source sequence(s)

AL136366

Consensus CDS

CCDS94387.1

UniProtKB/TrEMBL

A0A0S2Z4H3, Q5W0Y9

Related

ENSP00000370308.3, ENST00000380921.3

Conserved Domains (2) summary

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001429577.1 → NP_001416506.1 nuclear factor 1 B-type isoform 29

Status: VALIDATED

Source sequence(s)

AL136366, AL441963
NM_005596.3 → NP_005587.2 nuclear factor 1 B-type isoform 3

See identical proteins and their annotated locations for NP_005587.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks alternate exons in the 3' end, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.

Source sequence(s)

AI140312, AL441963, BC001283, BX648845, DA785516

Consensus CDS

CCDS6474.1

UniProtKB/Swiss-Prot

G3V1P1, H7BYE8, O00166, O00712, Q12858, Q5VW29, Q63HM5, Q6ZNF9, Q96J45

UniProtKB/TrEMBL

A0A1B0GWJ4, Q5VW28

Related

ENSP00000370346.3, ENST00000380959.7

Conserved Domains (3) summary

pfam00859
Location:209 → 415

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:10 → 47

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:69 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain

RNA

NR_161382.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL136366, AL441963
NR_161383.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL136366, AL441963
NR_161384.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL136366, AL441963
NR_161385.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL441963