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    Slc37a2 solute carrier family 37 (glycerol-3-phosphate transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 56857, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Slc37a2provided by MGI
    Official Full Name
    solute carrier family 37 (glycerol-3-phosphate transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1929693
    See related
    Ensembl:ENSMUSG00000032122 AllianceGenome:MGI:1929693
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ci2; G3PP; cI-2; Slc37a1
    Summary
    Predicted to enable glucose 6-phosphate:inorganic phosphate antiporter activity and glycerol-3-phosphate transmembrane transporter activity. Predicted to be involved in glucose-6-phosphate transport and phosphate ion transmembrane transport. Predicted to act upstream of or within glycerol-3-phosphate metabolic process; glycerol-3-phosphate transmembrane transport; and glycerophosphate shuttle. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human SLC37A2 (solute carrier family 37 member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in colon adult (RPKM 50.9), adrenal adult (RPKM 16.4) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 20.74 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (37140445..37166709, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (37229149..37255738, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 48716 Neighboring gene STARR-positive B cell enhancer mm9_chr9:36984672-36984973 Neighboring gene STARR-positive B cell enhancer ABC_E249 Neighboring gene STARR-seq mESC enhancer starr_23796 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:37038155-37038413 Neighboring gene transmembrane protein 218 Neighboring gene protein transport protein Sec61 subunit gamma pseudogene Neighboring gene coiled-coil domain containing 15 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 34885

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sugar transporter Slc37a2 regulates bone metabolism in mice via a tubular lysosomal network in osteoclasts. Ng PY, et al. Nat Commun, 2023 Feb 21. PMID 36810735, Free PMC Article
    2. Solute Carrier Family 37 Member 2 (SLC37A2) Negatively Regulates Murine Macrophage Inflammation by Controlling Glycolysis. Wang Z, et al. iScience, 2020 May 22. PMID 32428862, Free PMC Article
    3. The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue. Kim JY, et al. Am J Physiol Endocrinol Metab, 2007 Jul. PMID 17356011
    4. Hematopoietic Cell-Specific SLC37A2 Deficiency Accelerates Atherosclerosis in LDL Receptor-Deficient Mice. Zhao Q, et al. Front Cardiovasc Med, 2021. PMID 34957260, Free PMC Article
    5. Cloning and characterization of a putative human glycerol 3-phosphate permease gene (SLC37A1 or G3PP) on 21q22.3: mutation analysis in two candidate phenotypes, DFNB10 and a glycerol kinase deficiency. Bartoloni L, et al. Genomics, 2000 Dec 1. PMID 11112347

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
      Title: Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.
    2. Using both living fish embryos and mammalian macrophages, we show that processing depends on the shrinkage and packaging of phagosomes into a unique cellular compartment, the gastrosome, with distinct molecular and ultra-structural characteristics. Loss of the transporter Slc37a2 blocks phagosomal shrinkage, resulting in the expansion of the gastrosome and the dramatic bloating of the cell.
      Title: Clearance by Microglia Depends on Packaging of Phagosomes into a Unique Cellular Compartment.
    3. The function of this macrophage-specific putative sugar transporter is central to the metabolism of the macrophage population specifically present in obese white adipose tissue.
      Title: The major facilitator superfamily member Slc37a2 is a novel macrophage- specific gene selectively expressed in obese white adipose tissue.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2)  1 citation
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucose 6-phosphate:phosphate antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerol-3-phosphate transmembrane transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose-6-phosphate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucose-6-phosphate transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycerol-3-phosphate metabolic process ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerol-3-phosphate transmembrane transport ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within glycerophosphate shuttle ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in phosphate ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphate ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucose-6-phosphate exchanger SLC37A2
    Names
    cAMP inducible 2 protein
    cAMP inducible gene 2
    cAMP-inducible protein 2
    solute carrier family 37 (glycerol-3-phosphate transporter), member 1
    solute carrier family 37 member 2
    sugar phosphate exchanger 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145960.2 → NP_001139432.1  glucose-6-phosphate exchanger SLC37A2 isoform 1

      See identical proteins and their annotated locations for NP_001139432.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC138284, AC154434
      Consensus CDS
      CCDS52769.1
      UniProtKB/Swiss-Prot
      Q9WU81
      Related
      ENSMUSP00000124569.2, ENSMUST00000161114.2
      Conserved Domains (1) summary
      cl27298
      Location:25 → 478
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    2. NM_020258.5 → NP_064654.3  glucose-6-phosphate exchanger SLC37A2 isoform 2

      See identical proteins and their annotated locations for NP_064654.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC138284, AC154434
      Consensus CDS
      CCDS40582.1
      UniProtKB/Swiss-Prot
      Q571N8, Q6P4P0, Q8BV90, Q8C144, Q8R1Y0, Q9WU81
      Related
      ENSMUSP00000110720.3, ENSMUST00000115068.10
      Conserved Domains (1) summary
      cl27298
      Location:25 → 478
      UhpC; Sugar phosphate permease [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      37140445..37166709 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WU81.1 GenPept UniProtKB/Swiss-Prot:Q9WU81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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