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    Arpp19 cAMP-regulated phosphoprotein 19 [ Mus musculus (house mouse) ]

    Gene ID: 59046, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Arpp19provided by MGI
    Official Full Name
    cAMP-regulated phosphoprotein 19provided by MGI
    Primary source
    MGI:MGI:1891691
    See related
    Ensembl:ENSMUSG00000007656 AllianceGenome:MGI:1891691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    19kDa; Arpp12; ARPP-19; 2700024H10Rik
    Summary
    Predicted to enable potassium channel regulator activity; protein phosphatase inhibitor activity; and signaling receptor binding activity. Predicted to be involved in G2/M transition of mitotic cell cycle; negative regulation of protein dephosphorylation; and positive regulation of gluconeogenesis. Predicted to act upstream of or within cell division. Predicted to be active in cytoplasm. Is expressed in secondary oocyte. Orthologous to human ARPP19 (cAMP regulated phosphoprotein 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in cortex adult (RPKM 43.2), frontal lobe adult (RPKM 28.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 D; 9 42.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (74944896..74967595)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (75037614..75060313)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene one cut domain, family member 1 Neighboring gene predicted gene, 38678 Neighboring gene STARR-positive B cell enhancer ABC_E8300 Neighboring gene STARR-positive B cell enhancer ABC_E6765 Neighboring gene STARR-positive B cell enhancer ABC_E714 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74812784-74813085 Neighboring gene STARR-positive B cell enhancer mm9_chr9:74813338-74813639 Neighboring gene microRNA 1970c Neighboring gene atos homolog A Neighboring gene STARR-seq mESC enhancer starr_24651 Neighboring gene STARR-seq mESC enhancer starr_24653 Neighboring gene STARR-positive B cell enhancer ABC_E10563 Neighboring gene predicted gene, 51714 Neighboring gene apoptosis inhibitor 5 pseudogene Neighboring gene myosin VA Neighboring gene branched chain ketoacid dehydrogenase E1, beta polypeptide pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation by cAMP and vasoactive intestinal peptide of phosphorylation of specific proteins in striatal cells in culture. Girault JA, et al. Proc Natl Acad Sci U S A, 1988 Oct. PMID 2845422, Free PMC Article
    2. MicroRNA-320 induces neurite outgrowth by targeting ARPP-19. White RE, et al. Neuroreport, 2012 Jul 11. PMID 22617447, Free PMC Article
    3. ENSA and ARPP19 differentially control cell cycle progression and development. Hached K, et al. J Cell Biol, 2019 Feb 4. PMID 30626720, Free PMC Article
    4. ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase). Andrade EC, et al. J Neurosci, 2017 Mar 8. PMID 28167675, Free PMC Article
    5. ARPP-16/ARPP-19: a highly conserved family of cAMP-regulated phosphoproteins. Dulubova I, et al. J Neurochem, 2001 Apr. PMID 11279279

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cAMP-regulated phosphoprotein 19
    Names
    cAMP-regulated phosphoprotein ARPP-19
    cyclic AMP phosphoprotein, 19 kDa
    cyclic AMP phosphoprotein, 19kD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142655.1 → NP_001136127.1  cAMP-regulated phosphoprotein 19 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS52859.1
      UniProtKB/TrEMBL
      E9Q827
      Related
      ENSMUSP00000128921.2, ENSMUST00000169492.8
      Conserved Domains (1) summary
      pfam04667
      Location:61 → 136
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    2. NM_001357878.1 → NP_001344807.1  cAMP-regulated phosphoprotein 19 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS23340.1
      UniProtKB/Swiss-Prot
      P56212, Q543L2
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    3. NM_001357879.1 → NP_001344808.1  cAMP-regulated phosphoprotein 19 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS23340.1
      UniProtKB/Swiss-Prot
      P56212, Q543L2
      Related
      ENSMUSP00000132350.2, ENSMUST00000170308.8
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    4. NM_001357880.1 → NP_001344809.1  cAMP-regulated phosphoprotein 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 5 and 6 both encode the same isoform (3).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS90623.1
      Related
      ENSMUSP00000131597.2, ENSMUST00000167885.8
      Conserved Domains (1) summary
      pfam04667
      Location:12 → 87
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    5. NM_001357881.1 → NP_001344810.1  cAMP-regulated phosphoprotein 19 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (3) is shorter at the N-terminus compared to isoform 2. Variants 5 and 6 both encode the same isoform (3).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS90623.1
      Related
      ENSMUSP00000131987.2, ENSMUST00000166549.2
      Conserved Domains (1) summary
      pfam04667
      Location:12 → 87
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    6. NM_021548.4 → NP_067523.1  cAMP-regulated phosphoprotein 19 isoform 1

      See identical proteins and their annotated locations for NP_067523.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2. Variants 1, 3, and 4 all encode the same isoform (1).
      Source sequence(s)
      CT033761
      Consensus CDS
      CCDS23340.1
      UniProtKB/Swiss-Prot
      P56212, Q543L2
      Related
      ENSMUSP00000007800.8, ENSMUST00000007800.8
      Conserved Domains (1) summary
      pfam04667
      Location:28 → 103
      Endosulfine; cAMP-regulated phosphoprotein/endosulfine conserved region

    RNA

    1. NR_152135.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate internal segment compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      CT033761

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      74944896..74967595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P56212.2 GenPept UniProtKB/Swiss-Prot:P56212

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