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    Defb50 defensin beta 50 [ Mus musculus (house mouse) ]

    Gene ID: 387334, updated on 8-Feb-2024

    Summary

    Official Symbol
    Defb50provided by MGI
    Official Full Name
    defensin beta 50provided by MGI
    Primary source
    MGI:MGI:3055870
    See related
    Ensembl:ENSMUSG00000058568 AllianceGenome:MGI:3055870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pbd1; BD-50; mBD-50
    Summary
    Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Is expressed in medulla oblongata basal plate mantle layer; prostate gland lobe; skeletal muscle; testis; and ventral grey horn. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

    Location:
    8 A2; 8 10.41 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (22313557..22321312)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (21823539..21831296)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_20893 Neighboring gene defensin beta 1 Neighboring gene predicted gene 15316 Neighboring gene defensin beta 2 Neighboring gene defensin beta 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    acts_upstream_of_or_within defense response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-defensin 50
    Names
    defensin, beta 37
    prostate beta defensin 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199067.2NP_951022.1  beta-defensin 50 precursor

      See identical proteins and their annotated locations for NP_951022.1

      Status: VALIDATED

      Source sequence(s)
      AL590630
      Consensus CDS
      CCDS40283.1
      UniProtKB/Swiss-Prot
      Q30KM7, Q6TU36
      Related
      ENSMUSP00000077918.7, ENSMUST00000078879.7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      22313557..22321312
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)