Esyt2 extended synaptotagmin-like protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Esyt2provided by MGI
Official Full Name: extended synaptotagmin-like protein 2provided by MGI
Primary source: MGI:MGI:1261845
See related: Ensembl:ENSMUSG00000021171 AllianceGenome:MGI:1261845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam62b; CHR2SYT; D12Ertd551e; 2410017M09Rik; 4921504I16Rik
Summary: Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering. Predicted to act upstream of or within endocytosis and lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including aorta; genitourinary system; mammary gland; nervous system; and retina. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 4.1), frontal lobe adult (RPKM 3.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F2; 12 62.65 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (116242903..116354555)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (116279283..116390935)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
Title: Selective optogenetic activation of NaV1.7-expressing afferents in NaV1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli.
Mouse with deletions are generated:esyt2(-/-)/esyt3(-/-) develop normally and are viable and fertile; esyt2(-/-)/esyt3(-/-) embryonic fibroblasts show reduced ability to migrate, are less resistant to stringent culture conditions and to oxidative stress.
Title: Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected.
ChR2 expression had no discernable effect on the putative vasomotor neurons at rest
Title: Photostimulation of channelrhodopsin-2 expressing ventrolateral medullary neurons increases sympathetic nerve activity and blood pressure in rats.
Murine E-Syt2 was studied by small-angle X-ray scattering (SAXS) providing a three-dimensional image of a protein with three C2 domains.
Title: Structural characterization of soluble E-Syt2.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (6) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Ertd551e (e-PCR), detects polymorphism
- UniSTS:167093

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endocytosis	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum-plasma membrane tethering	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-plasma membrane contact site	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: extended synaptotagmin-2

Names: E-Syt2; chr2 synaptotagmin; family with sequence similarity 62 (C2 domain containing), member B; family with sequence similarity 62, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028731.5 → NP_083007.2 extended synaptotagmin-2

See identical proteins and their annotated locations for NP_083007.2

Status: VALIDATED

Source sequence(s)

AI838753, AK014813, AK044360, BC059230

Consensus CDS

CCDS26211.1

UniProtKB/Swiss-Prot

B2RSN5, Q3TZZ7, Q9D5Y7

Related

ENSMUSP00000098548.3, ENSMUST00000100986.4

Conserved Domains (4) summary

cd04030
Location:710 → 835

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 566

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

116242903..116354555

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246808.1 → XP_030102668.1 extended synaptotagmin-2 isoform X2

Conserved Domains (4) summary

cd04030
Location:744 → 869

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 600

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_017315129.2 → XP_017170618.1 extended synaptotagmin-2 isoform X1

Conserved Domains (4) summary

cd04030
Location:744 → 864

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 600

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_011244139.3 → XP_011242441.1 extended synaptotagmin-2 isoform X3

Conserved Domains (4) summary

cd04030
Location:731 → 851

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 587

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_030246810.1 → XP_030102670.1 extended synaptotagmin-2 isoform X5

Conserved Domains (4) summary

cd04030
Location:710 → 830

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 566

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_036157525.1 → XP_036013418.1 extended synaptotagmin-2 isoform X2

Conserved Domains (4) summary

cd04030
Location:744 → 869

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 600

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_006516075.4 → XP_006516138.1 extended synaptotagmin-2 isoform X7

Conserved Domains (2) summary

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_036157526.1 → XP_036013419.1 extended synaptotagmin-2 isoform X8

Conserved Domains (2) summary

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_017315131.1 → XP_017170620.1 extended synaptotagmin-2 isoform X6

Conserved Domains (4) summary

cd04030
Location:578 → 698

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:295 → 434

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:143 → 263

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:4 → 128

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain