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    Inpp4b inositol polyphosphate-4-phosphatase, type II [ Mus musculus (house mouse) ]

    Gene ID: 234515, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Inpp4bprovided by MGI
    Official Full Name
    inositol polyphosphate-4-phosphatase, type IIprovided by MGI
    Primary source
    MGI:MGI:2158925
    See related
    Ensembl:ENSMUSG00000037940 AllianceGenome:MGI:2158925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E130107I17Rik
    Summary
    Enables lipid binding activity; phosphatidylinositol bisphosphate phosphatase activity; and phosphatidylinositol trisphosphate phosphatase activity. Acts upstream of or within several processes, including negative regulation of osteoclast differentiation; regulation of bone remodeling; and regulation of protein kinase B signaling. Located in Golgi apparatus. Is expressed in several structures, including brain; ear; genitourinary system; heart; and musculoskeletal system. Orthologous to human INPP4B (inositol polyphosphate-4-phosphatase type II B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 1.6), cerebellum adult (RPKM 1.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 C2; 8 39.02 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (82068895..82865553)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (81342266..82134312)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coenzyme Q10 homolog B pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:83877485-83877786 Neighboring gene STARR-seq mESC enhancer starr_22053 Neighboring gene STARR-seq mESC enhancer starr_22054 Neighboring gene STARR-positive B cell enhancer mm9_chr8:83898997-83899298 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 51582 Neighboring gene STARR-positive B cell enhancer mm9_chr8:84002682-84002982 Neighboring gene STARR-seq mESC enhancer starr_22055 Neighboring gene STARR-seq mESC enhancer starr_22056 Neighboring gene SNARE-associated protein Snapin pseudogene Neighboring gene STARR-seq mESC enhancer starr_22059 Neighboring gene voltage-dependent anion channel 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22060 Neighboring gene STARR-seq mESC enhancer starr_22061 Neighboring gene STARR-seq mESC enhancer starr_22062 Neighboring gene STARR-seq mESC enhancer starr_22063 Neighboring gene predicted gene, 53442 Neighboring gene predicted gene, 25267 Neighboring gene predicted gene 9520

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. INPP4B protects from metabolic syndrome and associated disorders. Zhang M, et al. Commun Biol, 2021 Mar 26. PMID 33772116, Free PMC Article
    2. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice. Ceyhan Y, et al. PLoS One, 2020. PMID 32413098, Free PMC Article
    3. Investigating the duality of Inpp4b function in the cellular transformation of mouse fibroblasts. Mangialardi EM, et al. Oncotarget, 2019 Oct 29. PMID 31695845, Free PMC Article
    4. Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice. Ji L, et al. Mol Cells, 2016 Jun 30. PMID 27109423, Free PMC Article
    5. Phosphatidylinositol 4-phosphatase type II is an erythropoietin-responsive gene. Barnache S, et al. Oncogene, 2006 Mar 2. PMID 16247441

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
      Title: Regulation of B-1 cell numbers and B cell-mediated antibody production by Inpp4b.
    2. Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
      Title: Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity.
    3. We showed that Inpp4b is an essential regulator of metabolic health. Male Inpp4b knockout mice fed high fat diet develop type 2 diabetes. Inpp4b expression protects the liver from steatosis, mediates insulin sensitivity, and links obesity to neoplastic changes in the prostate epithelium.
      Title: INPP4B protects from metabolic syndrome and associated disorders.
    4. The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
      Title: The INPP4B Tumor Suppressor Modulates EGFR Trafficking and Promotes Triple-Negative Breast Cancer.
    5. Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
      Title: Deletion of inositol polyphosphate 4-phosphatase type-II B affects spermatogenesis in mice.
    6. data show that INPP4B modulates AR activity in normal prostate and its loss contributes to the AR-dependent transcriptional profile in prostate cancer.
      Title: Inositol polyphosphate 4-phosphatase type II regulation of androgen receptor activity.
    7. Data provides evidence that INPP4B may play a role in regulating callosal axon formation by the formation of Satb2-positive pyramidal neurons and controlling axon polarization.
      Title: Depletion of Inositol Polyphosphate 4-Phosphatase II Suppresses Callosal Axon Formation in the Developing Mice.
    8. Results provide evidence that INPP4B is a bona fide tumor suppressor whose function is particularly important in situations of PTEN deficiency. Biochemical data demonstrates that INPP4B directly dephosphorylates PtdIns(3,4,5)P3.
      Title: INPP4B Is a PtdIns(3,4,5)P3 Phosphatase That Can Act as a Tumor Suppressor.
    9. Study provides evidence that INPP4B loss can promote follicular-like thyroid cancer progression and metastasis in the context of PTEN haploinsufficiency through the isoform-specific regulation of AKT signaling at the endosomes.
      Title: In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
    10. ERalpha plays a protective role in bladder cancer initiation and growth at least partly via modulating the INPP4B/Akt pathway.
      Title: Estrogen receptor alpha prevents bladder cancer via INPP4B inhibited akt pathway in vitro and in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol bisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol trisphosphate phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular calcium ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of bone remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of nucleocytoplasmic transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    type II inositol 3,4-bisphosphate 4-phosphatase
    Names
    D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase
    phosphatidylinositol-3,4-bisphosphate 4-phosphatase
    phosphoinositide 4-phosphatase
    NP_001019788.1
    NP_001284520.1
    NP_001284522.1
    NP_001284525.1
    XP_006530917.1
    XP_006530918.1
    XP_006530919.1
    XP_006530921.1
    XP_006530924.1
    XP_006530925.1
    XP_006530926.1
    XP_011246653.1
    XP_011246654.1
    XP_017168215.1
    XP_017168217.1
    XP_017168218.1
    XP_030099350.1
    XP_036009844.1
    XP_036009845.1
    XP_036009846.1
    XP_036009847.1
    XP_036009848.1
    XP_036009849.1
    XP_036009850.1
    XP_036009851.1
    XP_036009852.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024617.3 → NP_001019788.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 2

      See identical proteins and their annotated locations for NP_001019788.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC115778, AK139397, BC064813, DQ296611
      Consensus CDS
      CCDS22446.1
      UniProtKB/Swiss-Prot
      Q6P1Y8
      UniProtKB/TrEMBL
      Q1A6U9
      Related
      ENSMUSP00000044466.7, ENSMUST00000042529.14
      Conserved Domains (1) summary
      cd04048
      Location:39 → 158
      C2A_Copine; C2 domain first repeat in Copine

    2. NM_001297591.1 → NP_001284520.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001284520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK139397, AK141502, DQ296613
      Consensus CDS
      CCDS80901.1
      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Related
      ENSMUSP00000150541.2, ENSMUST00000217122.2
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    3. NM_001297593.1 → NP_001284522.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon and uses an alternate last exon compared to variant 1. The resulting isoform (3) has shorter and distinct N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC121136, AK141502, DQ296611, DQ296612
      UniProtKB/TrEMBL
      Q1A6V0
      Conserved Domains (1) summary
      cl14603
      Location:25 → 114
      C2; C2 domain

    4. NM_001297596.1 → NP_001284525.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform 4

      See identical proteins and their annotated locations for NP_001284525.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate last exon compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC121136, AK141502, DQ296611
      Consensus CDS
      CCDS80902.1
      UniProtKB/TrEMBL
      E9PVM1, Q1A6V1
      Related
      ENSMUSP00000148972.2, ENSMUST00000215332.2
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      82068895..82865553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153952.1 → XP_036009845.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

      UniProtKB/TrEMBL
      Q1A6V1
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    2. XM_011248351.3 → XP_011246653.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011246653.1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    3. XM_036153951.1 → XP_036009844.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    4. XM_006530855.3 → XP_006530918.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006530918.1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    5. XM_030243490.1 → XP_030099350.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

      UniProtKB/TrEMBL
      Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    6. XM_006530856.3 → XP_006530919.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006530919.1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    7. XM_006530861.4 → XP_006530924.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X5

      UniProtKB/TrEMBL
      F8WJC1
      Conserved Domains (1) summary
      cl14603
      Location:25 → 114
      C2; C2 domain

    8. XM_017312729.3 → XP_017168218.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X4

      UniProtKB/TrEMBL
      Q1A6V1
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    9. XM_006530858.4 → XP_006530921.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X3

      See identical proteins and their annotated locations for XP_006530921.1

      UniProtKB/TrEMBL
      E9PVM1, Q1A6V1
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    10. XM_036153959.1 → XP_036009852.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X10

      UniProtKB/TrEMBL
      Q1A6V1
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    11. XM_006530854.4 → XP_006530917.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_006530917.1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    12. XM_017312728.3 → XP_017168217.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X2

      UniProtKB/TrEMBL
      Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    13. XM_036153953.1 → XP_036009846.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X6

      UniProtKB/TrEMBL
      F8WJC1
      Conserved Domains (1) summary
      cl14603
      Location:25 → 97
      C2; C2 domain

    14. XM_036153954.1 → XP_036009847.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X7

      UniProtKB/TrEMBL
      Q3URI3
      Related
      ENSMUSP00000150520.2, ENSMUST00000213285.2
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    15. XM_011248352.3 → XP_011246654.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      See identical proteins and their annotated locations for XP_011246654.1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    16. XM_017312726.2 → XP_017168215.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X1

      UniProtKB/TrEMBL
      E9PVM3, Q1A6U9
      Conserved Domains (1) summary
      cd04048
      Location:39 → 175
      C2A_Copine; C2 domain first repeat in Copine

    17. XM_036153955.1 → XP_036009848.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

      UniProtKB/TrEMBL
      F8WJC1

    18. XM_036153958.1 → XP_036009851.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

      UniProtKB/TrEMBL
      F8WJC1
      Related
      ENSMUSP00000132156.2, ENSMUST00000170160.8

    19. XM_006530862.4 → XP_006530925.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

      See identical proteins and their annotated locations for XP_006530925.1

      UniProtKB/TrEMBL
      F8WJC1

    20. XM_036153956.1 → XP_036009849.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

      UniProtKB/TrEMBL
      Q1A6V0

    21. XM_006530863.5 → XP_006530926.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X8

      See identical proteins and their annotated locations for XP_006530926.1

      UniProtKB/TrEMBL
      F8WJC1
      Related
      ENSMUSP00000105477.3, ENSMUST00000109851.3

    22. XM_036153957.1 → XP_036009850.1  type II inositol 3,4-bisphosphate 4-phosphatase isoform X9

      UniProtKB/TrEMBL
      Q1A6V0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P1Y8.1 GenPept UniProtKB/Swiss-Prot:Q6P1Y8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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