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    Dennd2b DENN domain containing 2B [ Mus musculus (house mouse) ]

    Gene ID: 76954, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dennd2bprovided by MGI
    Official Full Name
    DENN domain containing 2Bprovided by MGI
    Primary source
    MGI:MGI:108517
    See related
    Ensembl:ENSMUSG00000031024 AllianceGenome:MGI:108517
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    St5; Denn2b; 2010004M01Rik; 2610305K15Rik
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of ERK1 and ERK2 cascade. Predicted to be located in endosome and plasma membrane. Is expressed in several structures, including brain; future brain; head mesenchyme; heart; and primary palate. Orthologous to human DENND2B (DENN domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in lung adult (RPKM 22.8), ovary adult (RPKM 12.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    7 E3; 7 57.27 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (109123118..109302828, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (109523911..109703718, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24888 Neighboring gene ribosomal protein L27A Neighboring gene small nucleolar RNA, H/ACA box 3 Neighboring gene STARR-seq mESC enhancer starr_19802 Neighboring gene STARR-seq mESC enhancer starr_19804 Neighboring gene STARR-positive B cell enhancer ABC_E4965 Neighboring gene VISTA enhancer mm1407 Neighboring gene A kinase interacting protein 1 Neighboring gene cDNA sequence BC051019 Neighboring gene predicted gene, 51493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice. Ou K, et al. Mol Metab, 2018 May. PMID 29650351, Free PMC Article
    2. Disruption of ST5 is associated with mental retardation and multiple congenital anomalies. Göhring I, et al. J Med Genet, 2010 Feb. PMID 19843505
    3. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Kleyn PW, et al. Cell, 1996 Apr 19. PMID 8612280
    4. Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1). Cichutek A, et al. Cytogenet Cell Genet, 2001. PMID 11528126
    5. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. Amid C, et al. Cytogenet Cell Genet, 2001. PMID 11528127

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ST5 overexpression has no mitogenic effect on the adult beta-cell under basal and metabolically challenged states.
      Title: Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2B
    Names
    heLa tumor suppression 1
    suppression of tumorigenicity 5 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001326.1 → NP_001001326.1  DENN domain-containing protein 2B isoform 1

      See identical proteins and their annotated locations for NP_001001326.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AC124457, AC126441
      Consensus CDS
      CCDS21734.1
      UniProtKB/Swiss-Prot
      Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
      Related
      ENSMUSP00000078264.2, ENSMUST00000079282.8
      Conserved Domains (3) summary
      smart00801
      Location:1020 → 1086
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 969
      DENN; DENN (AEX-3) domain

    2. NM_029811.2 → NP_084087.2  DENN domain-containing protein 2B isoform 2

      See identical proteins and their annotated locations for NP_084087.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC124457, AC126441
      Consensus CDS
      CCDS21735.1
      UniProtKB/Swiss-Prot
      Q924W7
      Related
      ENSMUSP00000130119.2, ENSMUST00000168005.8
      Conserved Domains (3) summary
      smart00801
      Location:603 → 669
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:277 → 364
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:371 → 552
      DENN; DENN (AEX-3) domain

    RNA

    1. NR_037617.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC124457, AK008100, CF737707, CF749727, CN460946

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      109123118..109302828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241941.3 → XP_011240243.1  DENN domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011240243.1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    2. XM_030243084.2 → XP_030098944.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    3. XM_011241940.4 → XP_011240242.1  DENN domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011240242.1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    4. XM_011241945.4 → XP_011240247.1  DENN domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011240247.1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    5. XM_036153554.1 → XP_036009447.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    6. XM_011241944.4 → XP_011240246.1  DENN domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011240246.1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    7. XM_030243087.2 → XP_030098947.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    8. XM_030243086.2 → XP_030098946.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    9. XM_011241942.4 → XP_011240244.1  DENN domain-containing protein 2B isoform X1

      See identical proteins and their annotated locations for XP_011240244.1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    10. XM_030243085.1 → XP_030098945.1  DENN domain-containing protein 2B isoform X1

      Conserved Domains (3) summary
      smart00801
      Location:1045 → 1111
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:813 → 994
      DENN; DENN (AEX-3) domain

    11. XM_030243089.2 → XP_030098949.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
      Conserved Domains (3) summary
      smart00801
      Location:1020 → 1086
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 969
      DENN; DENN (AEX-3) domain

    12. XM_006508320.5 → XP_006508383.1  DENN domain-containing protein 2B isoform X2

      See identical proteins and their annotated locations for XP_006508383.1

      UniProtKB/Swiss-Prot
      Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
      Conserved Domains (3) summary
      smart00801
      Location:1020 → 1086
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 969
      DENN; DENN (AEX-3) domain

    13. XM_030243088.2 → XP_030098948.1  DENN domain-containing protein 2B isoform X2

      UniProtKB/Swiss-Prot
      Q05BD9, Q78H54, Q8K2P3, Q924W7, Q924W8
      Related
      ENSMUSP00000077067.2, ENSMUST00000077909.9
      Conserved Domains (3) summary
      smart00801
      Location:1020 → 1086
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:788 → 969
      DENN; DENN (AEX-3) domain

    14. XM_036153555.1 → XP_036009448.1  DENN domain-containing protein 2B isoform X4

      UniProtKB/TrEMBL
      Q3TYX0
      Conserved Domains (1) summary
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    15. XM_030243090.2 → XP_030098950.1  DENN domain-containing protein 2B isoform X3

      UniProtKB/TrEMBL
      Q3TYX0
      Conserved Domains (1) summary
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    16. XM_030243091.2 → XP_030098951.1  DENN domain-containing protein 2B isoform X5

      UniProtKB/TrEMBL
      Q3TYX0
      Conserved Domains (1) summary
      smart00800
      Location:694 → 781
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins

    RNA

    1. XR_003946582.2 RNA Sequence

    2. XR_004934206.1 RNA Sequence

    3. XR_004934205.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924W7.1 GenPept UniProtKB/Swiss-Prot:Q924W7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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