Clec5a C-type lectin domain family 5, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec5aprovided by MGI
Official Full Name: C-type lectin domain family 5, member aprovided by MGI
Primary source: MGI:MGI:1345151
See related: Ensembl:ENSMUSG00000029915 AllianceGenome:MGI:1345151
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mdl1; Ly100; MDL-1; Clecsf5
Summary: Enables virus receptor activity. Involved in several processes, including innate immune response; negative regulation of apoptotic process; and osteoblast development. Acts upstream of or within myeloid cell differentiation and negative regulation of myeloid cell apoptotic process. Located in cell surface. Orthologous to human CLEC5A (C-type lectin domain containing 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 1.9), liver E14 (RPKM 1.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 18.82 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (40551832..40562739, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (40574898..40585805, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CLEC5A mediates Zika virus-induced testicular damage.
Title: CLEC5A mediates Zika virus-induced testicular damage.
CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury.
Title: CLEC5A is critical in Pseudomonas aeruginosa-induced NET formation and acute lung injury.
CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis.
Title: CLEC5A knockdown protects against cardiac dysfunction after myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation, and pyroptosis.
Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy.
Title: Genetic loss-of-function of activating transcription factor 3 but not C-type lectin member 5A prevents diabetic peripheral neuropathy.
MDL-1 is mainly expressed in atherosclerotic lesional macrophages and increased macrophage MDL-1 expression is associated with early plaque progression and promotes macrophage survival.
Title: The macrophage C-type lectin receptor CLEC5A (MDL-1) expression is associated with early plaque progression and promotes macrophage survival.
CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis
Title: CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis.
Data show that C-type lectin member 5A (CLEC5A) is needed for optimal reactive oxygen species (ROS) production, neutrophil extracellular traps (NETs) formation and other immune responses to Listeria monocytogenes in mice.
Title: CLEC5A is a critical receptor in innate immunity against Listeria infection.
The results suggest that CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo and may be considered a therapeutic target in combination with effective antivirals.
Title: CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In Vivo.
cigarette smoke-induced macrophage responsiveness is mediated by CLEC5A, and CLEC5A is required for the development of inflammation, proinflammatory cytokine expression, and airspace enlargement.
Title: Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.
Japanese encephalitis virus (JEV) directly interacts with CLEC5A and induces DAP12 phosphorylation in macrophages.
Title: CLEC5A regulates Japanese encephalitis virus-induced neuroinflammation and lethality.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (7)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables virus receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in osteoblast development	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: C-type lectin domain family 5 member A

Names: C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 5; C-type lectin superfamily member 5; myeloid DAP12-associating lectin 1; type II transmembrane protein MDL-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038604.1 → NP_001033693.1 C-type lectin domain family 5 member A isoform 1

See identical proteins and their annotated locations for NP_001033693.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK036697, AK137482, BY205833, CN670295

Consensus CDS

CCDS20036.1

UniProtKB/Swiss-Prot

Q3SXC9, Q3UV97, Q8BL24, Q9R007

UniProtKB/TrEMBL

A0A0R4J269

Related

ENSMUSP00000121848.3, ENSMUST00000129948.9

Conserved Domains (1) summary

cd03593
Location:73 → 186

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
NM_021364.2 → NP_067339.1 C-type lectin domain family 5 member A isoform 2

See identical proteins and their annotated locations for NP_067339.1

Status: PROVISIONAL

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK036697, AK137482, BY205833

Consensus CDS

CCDS20037.1

UniProtKB/TrEMBL

A0A0R4J269

Related

ENSMUSP00000099030.5, ENSMUST00000101491.11

Conserved Domains (1) summary

cd03593
Location:48 → 161

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)