Cd80 CD80 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd80provided by MGI
Official Full Name: CD80 antigenprovided by MGI
Primary source: MGI:MGI:101775
See related: Ensembl:ENSMUSG00000075122 AllianceGenome:MGI:101775
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B71; Ly53; TSA1; Cd28l; Ly-53; MIC17
Summary: Predicted to enable coreceptor activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 16 B4; 16 26.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (38277793..38316682)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (38457430..38495958)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
Title: Absence of CD80 reduces HSV-1 replication in the eye and delays reactivation but not latency levels.
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8[+] T cell function and anti-tumor immunity.
Title: cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8(+) T cell function and anti-tumor immunity.
CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
Title: CTLA-4-Ig internalizes CD80 in fibroblast-like synoviocytes from chronic inflammatory arthritis mouse model.
Lack of Functional P110delta Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
Title: Lack of Functional P110δ Affects Expression of Activation Marker CD80 but Does Not Influence Functions of Neutrophils.
Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-gamma(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
Title: Suppression of CD80 Expression by ICP22 Affects Herpes Simplex Virus Type 1 Replication and CD8(+)IFN-γ(+) Infiltrates in the Eyes of Infected Mice but Not Latency Reactivation.
B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Title: B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms.
Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
Title: Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.
these results suggest that increased CD80 levels promote increased CD8(+) T cells, leading to exacerbated eye disease in HSV-1-infected mice.
Title: CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.
This study provide evidence for a major role of CD80 in orchestrating immune surveillance of colon preneoplastic lesions and might help to develop novel approaches that exploit anti-tumor immunity to prevent and control colon cancer.
Title: Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells.
CD28 may play a role in LPS nephropathy. Immunofluorescence colocalization analysis revealed a tight association of gammadeltaT cells with B7-1 in the kidney. High B7-1 expression was detected in podocytes treated with LPS.
Title: γδT Cells Exacerbate Podocyte Injury via the CD28/B7-1-Phosphor-SRC Kinase Pathway.

Submit: New GeneRIF Correction See all GeneRIFs (143)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation
Endonuclease-mediated (9) 1 citation

General gene information

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Markers

Ckb (e-PCR), detects polymorphism
- UniSTS:472872

BF402875 (e-PCR)
- UniSTS:245959

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	ISO Inferred from Sequence Orthology more info
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: T-lymphocyte activation antigen CD80

Names: B7 protein; activation B7-1 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359898.1 → NP_001346827.1 T-lymphocyte activation antigen CD80 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC209577

Consensus CDS

CCDS28168.1

UniProtKB/Swiss-Prot

Q00609, Q61332

UniProtKB/TrEMBL

Q3U4B5, Q549R2, Q9R1Z9

Conserved Domains (2) summary

cd16083
Location:145 → 235

IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80

cd16086
Location:39 → 142

IgV_CD80; Immunoglobulin variable domain (IgV) in CD80
NM_009855.2 → NP_033985.3 T-lymphocyte activation antigen CD80 precursor

See identical proteins and their annotated locations for NP_033985.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC154425, X60958

Consensus CDS

CCDS28168.1

UniProtKB/Swiss-Prot

Q00609, Q61332

UniProtKB/TrEMBL

Q3U4B5, Q549R2, Q9R1Z9

Related

ENSMUSP00000097404.3, ENSMUST00000099816.3

Conserved Domains (2) summary

cd16083
Location:145 → 235

IgC_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor CD80

cd16086
Location:39 → 142

IgV_CD80; Immunoglobulin variable domain (IgV) in CD80

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

38277793..38316682

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159758.1 → XP_036015651.1 T-lymphocyte activation antigen CD80 isoform X1

UniProtKB/TrEMBL

Q3U4B5

Related

ENSMUSP00000156031.2, ENSMUST00000231716.2

Conserved Domains (2) summary

cd16086
Location:47 → 150

IgV_CD80; Immunoglobulin variable domain (IgV) in Cluster of Differentiation (CD) 80

cd16083
Location:153 → 243

IgC1_CD80; Immunoglobulin constant (IgC)-like domain of antigen receptor Cluster of Differentiation (CD) 80; member of the C1-set of Ig superfamily (IgSF) domains
XM_030248945.2 → XP_030104805.1 T-lymphocyte activation antigen CD80 isoform X2

Related

ENSMUSP00000156252.2, ENSMUST00000232409.2

Conserved Domains (1) summary

cl11960
Location:47 → 150

Ig; Immunoglobulin domain